o — 4th Street Bar

Systemin is a plant peptide hormone involved in the wound response in the family Solanaceae. It was the first plant hormone that was proven to be a peptide.

The receptor for systemin was first thought to be the same as the brassinolide receptor but this is now uncertain. The signal transduction processes that occur after the peptides bind are similar to the cytokine-mediated inflammatory immune response in animals.

https://en.m.wikipedia.org/wiki/Plant_peptide_hormone

https://en.m.wikipedia.org/wiki/Plant_defensin

https://en.m.wikipedia.org/wiki/Systemin

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wonder if global warming fungus toxic mutation hypothesis & superprion pandemic, have anything in common?

how can prion self assemble Tunnelling Nanotubes (TNTs) if its not a living "thing"?

just seems similar to how a slime mold has a brain, without a brain, retains memory.

so prion is.. self assembling, makes microtubules, a hydrogel, a spike protein, is nearly indestructible, airborne shedding & seems to have a brain without a brain?

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Synthetic Thioesters of Thiamine: Promising Tools for Slowing Progression of Neurodegenerative Diseases

https://www.mdpi.com/1422-0067/24/14/11296

Tunnelling nanotubes between neuronal and microglial cells allow bi-directional transfer of α-Synuclein and mitochondria

https://www.nature.com/articles/s41419-023-05835-8

Plastid transit peptides—where do they come from and where do they all belong? Multi-genome and pan-genomic assessment of chloroplast transit peptide evolution

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7456531/

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speculating on the evolution or origin of prion, regarding malaria apicoplast & plastid biogenesis.

alga something infecting mitochondria, misfolding proteins, making prion peptide.

meaning the definition of a virus as not alive is possibly outdated logic.

just speculating on the evolution or origin of prion, regarding malaria apicoplast & plastid biogenesis.

the alga endosymbiont (virus) requires mitochondria to habitat, otherwise goes dormant into spike-prion encapsulated seed or spore as self assembling hydrogel plaque, similar to bacteria biofilm.

this unusual extremophile plastid (mitochondria alga) weaponized with gmo mycoplasma fermentans, renamed a bacterial plasmid, goes dormant in any environment besides bone marrow or mitochondria, manufacturing spike spores to reinfect other cells, and mislabeled the replication as a non living virus.

one of the biggest clues is how the metabolism & enzyme activators flip both carbohydrates & lipids.

thats the most important part of all disease, parasites, genetic disorders, and everything else.

unusual symptoms of taking B1 & NAC, sometimes with Vitamin-C, MSM & Minerals, specially including Magnesium & Molybdenum.

the first few days is a cold feeling, about the 4th day is a warm feeling, as the enzymes go into the next phase, ear ringing, head pressure, flushing, agitation, aches in old injuries, skin smoothness, fungus infection inflammation into itchy, yet going away.

articles regarding NAC against Candida.

its making my 30 year old feet problem stop peeling, yet its still itchy, almost like a healing itch.

i dont know if its an absolute remedy yet, but something different is happening.

my skin thickness has gone down as well, possibly even dandruff.

if ibwas to attempt to make the same kind of medicine, it would be something like honey, citric (vinegar), sulfur & nitrogen from streamed plant biomass.

added all together, slowly steamed until caramelized.

Thiamine B1 is documented to cycle repair metabolism enzymes for 3 weeks to a month.

its a vitamin & medicine, but does require other things to make it continue going.

Quinine Hydroxychloroquine is said to last a month as well.

the trick is Heterocyclic Compounds compose of over 50 million known examples.

but requires very specific factors to get them flipping enzyme reactions

its not important to get the exact Heterocyclic Compound arrangement, just to get them moving along the correct enzymatic pathways, apposed to building up plaques.

i suspect if the enzymes move along correctly for long enough, it will not only dissolve biofilm, amyloid plaque, hydrogels, but eventually break down the parasitic or pathogenic host via pathways; prion, viruses ect..

or knock the parasite to learning how to behave nicely, and protect the immune system.

Mount Pinos
Mount Rubidoux
Jurupa Valley
Gabrielino Tribe
Serrano Tribe
John Peabody Harrington

https://en.m.wikipedia.org/wiki/Mount_Rubidoux

https://en.m.wikipedia.org/wiki/Mount_Pinos

https://en.m.wikipedia.org/wiki/Kizh

https://en.m.wikipedia.org/wiki/Tongva

https://en.m.wikipedia.org/wiki/Chumash_people

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theroy regarding Jesus 1000 years of peace, already happened, and this is why the entire world is literally fully loaded with greek like temple structures, star forts, ect...

after the fall of Atlantis (Old Testament) everything was destroyed, then a crawling back into empires from the surviving (Sumerian).

once they went back into full warfare & debauchery, Jesus was born, and promised to return shortly, and rule for 1000 years.

rebuilding the world into a literal utopian riddled with mysterious coded buildings & libraries, then retreated back away once the time & requirements were completed.

then some kind of Phoenix Rapture or sky event, this caused some kind of world mud flood, wheat & shaft & destroyed the unworthy to rebuild in the ruins.

the devil has but a short time to rule until the final judgment.

and the masonic Odd Fellows, Circuses, Bankers, Rothschild Nelphlim dragon hybrid bloodlines re-populated America with a breeding program, world fairs, cabbage patch orphans, railroads by Tartarian Chinese slaves ect..

not to mention the quantum computer technology put deep within rhe earth energy grid points, to hyjack the true matrix, with a false one, an overly.

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not about the engine, its a particle accelerater, it opens up "things", its not an easy thing to explain.

took me many years to figure out how the engine works, its like a ramjet, with multiple blast chambers, that would spin the combustion into a toroidal venturi chimney draw, then slowly incorporate water into the intake upwards, the top chamber will eventually build up an unusual cold gas element that would slowly move downward, pulling back in, creating a lightning storm effect, in the toroidal chamber.

once this process has gone into full temperature, the ceramics will fuse into some kind of amorphous magnetic material, and will no longer require regular fuel.

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what about how the jews never wrote the Bible, but stole it, then re-wrote it, is why mythology mimics it.

all the jews wrote was the Talmud.

the ancient megalithic structures, biblical battles, them wernt jews.

they took the history of a previous civilization, as there own.

Methylene Blue
Thionine
Quinine
Thiamine
Acetylcysteine
Methylsulfonylmethane

https://en.m.wikipedia.org/wiki/Methylene_blue

https://en.m.wikipedia.org/wiki/Quinine

https://en.m.wikipedia.org/wiki/Thionine

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5-Membered
Heterocyclic Compound

Furan (Vitamin C)
Thiazol (Vitamin B1)

https://en.m.wikipedia.org/wiki/Furan

https://en.m.wikipedia.org/wiki/Thiazole

Acetyl
Allyl

N-Acetylcysteine (NAC)
S-Allylcysteine (SAC)

Neuroprotective mechanisms of S-allyl-L-cysteine in neurological disease

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6966174/

Organosulfurs, S-allyl cysteine and N-acetyl cysteine sequester di-carbonyls and reduces carbonyl stress in HT22 cells

https://www.nature.com/articles/s41598-023-40291-6

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Serine
Cysteine
Glycine

Amino Acid Synthesis
Mitochondria DNA
One-Carbon Metabolism

Cystathionine
Methionine
Thionine

Glycine Synthesis
Acetic Acid
Glycine Cleavage System (GCS)
Reductive Glycine Pathway (rGlyP)

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Targeting serine-glycine-one-carbon metabolism as a vulnerability in cancers

https://biomarkerres.biomedcentral.com/articles/10.1186/s40364-023-00487-4

Glycine: The Smallest Anti-Inflammatory Micronutrient

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10379184/

Glycine, also known as amino acetic acid

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(MTHFR)
Methylenetetrahydrofolate Reductase

https://en.m.wikipedia.org/wiki/Methylenetetrahydrofolate_reductase

https://en.m.wikipedia.org/wiki/Cystathionine_beta_synthase

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Glycine is metabolized to oxalate in a B6 and thiamine deficient state, but when there is adequate B6 and thiamine, glycine does not become oxalate.

Marginally Insufficient Thiamine Intake and Oxalates

https://www.hormonesmatter.com/marginally-insufficient-thiamine-intake-oxalates/

Oxalate: A Potential Contributor to Hypervitaminosis A

https://www.hormonesmatter.com/oxalate-a-potential-contributor-to-hypervitaminosis-a/

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Glycine
Oxalate Toxicity
NADH NAD Enzyme
Retinol
Retinoic Acid

The Therapeutic Potential of Vitamins B1, B3 and B6 in Charcot–Marie–Tooth Disease

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10376249/

B6:
Pyridoxal Phosphate
Biosynthesis

https://en.m.wikipedia.org/wiki/Pyridoxal_phosphate#Biosynthesis

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Oxalate
Prion
Amyloid

oxalate ligand

https://en.m.wikipedia.org/wiki/Transition_metal_oxalate_complex

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Vitamin B6 in Health and Disease

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8467949/

the combination of vitamins B6 and B1 significantly reduced glycation of nuclear DNA in leukocytes.

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Oxalate: A Potential Contributor to Hypervitaminosis A

https://www.hormonesmatter.com/oxalate-a-potential-contributor-to-hypervitaminosis-a/

https://www.hormonesmatter.com/marginally-insufficient-thiamine-intake-oxalates/

Inhibitory potential of nitrogen, oxygen and sulfur containing heterocyclic scaffolds against acetylcholinesterase and butyrylcholinesterase

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9275557/

https://en.m.wikipedia.org/wiki/Chloroplast#Starch_granules

Pyrenoid
Starch Granules
Heterotrophic Microalgae

Starch granules are very common in chloroplasts, and in some other plastids like amyloplasts.

In red algae, starch granules are found in the cytoplasm rather than in the chloroplast.

Starch granules are composed of two distinct glucose polymers - amylose and amylopectin. Amylose constitutes 5-35% of most natural starches and has a major influence over starch properties in foods. Its synthesis and storage occurs within the semicrystalline amylopectin matrix of starch granules.

Cytoplasm
Starch Granule
Resistant Starch
Amyloplast
Amylose
Prion
Peptide
Semi-Crystalline
Amylopectin

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Prion
Glycosylphosphatidylinositol
p53

https://en.m.wikipedia.org/wiki/Glycosylphosphatidylinositol

https://en.m.wikipedia.org/wiki/P53

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The Multifaceted Functions of Prion Protein (PrPC) in Cancer

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10605613/

p53 amyloid aggregation in cancer: function, mechanism, and therapy

https://ehoonline.biomedcentral.com/articles/10.1186/s40164-022-00317-7

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Prion
Glycosylphosphatidylinositol

Prion protein contains two N-linked glycosylation sites and a glycosylphosphatidylinositol (GPI) anchor.

The large size of the N-linked sugars, together with their dynamic properties, enables them to shield two orthogonal faces of the protein almost completely. Thus, the sugars can protect large regions of the protein surface from proteases and from nonspecific protein−protein interactions.

Immunoprecipitation of prion protein with calnexin suggests that in the ER the oligosaccharides may provide a route for protein folding via the calnexin pathway.

Glycan analysis has shown that prion protein contains at least 52 different sugars, that these consist of a subset of brain sugars, and that there is site specific glycan processing.

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Oligosaccharide
Oligonucleotide
Glycoprotein

Glycosylphosphatidylinositol

malaria toxin ..
glycosylphosphatidylinositol
(GPI) anchor

Synthesis and medical applications of oligosaccharides

https://www.nature.com/articles/nature05819

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Methylglyoxal

https://en.m.wikipedia.org/wiki/Methylglyoxal

Role of Methylglyoxal in Alzheimer's Disease

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3966409/

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A Case of Cellulitis Associated with Coral Injury

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4903982/

i was told by a marine biologist, if Coral Reef is not completely removed from a cut, it will begin growing inside your body, onto the bone

wonder if the prion inserts have anything in common with coral?

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Coral Spherulite Crystals

Corals carefully organize proteins to form rock-hard skeletons

https://www.sciencedaily.com/releases/2021/04/210408131455.htm

Crystal nucleation and growth of spherulites demonstrated by coral skeletons and phase-field simulations

https://www.sciencedirect.com/science/article/pii/S1742706120303573

How do coral barnacles start their life in their hosts?

https://royalsocietypublishing.org/doi/10.1098/rsbl.2016.0124

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Crystallization of Polymers

https://en.m.wikipedia.org/wiki/Crystallization_of_polymers

https://en.m.wikipedia.org/wiki/Zooxanthellae

https://en.m.wikipedia.org/wiki/Pyrenoid

https://en.m.wikipedia.org/wiki/Prototheca

https://en.m.wikipedia.org/wiki/Algaemia

Cnidarian
Corals
Jellyfish
Sea Anemones
Hydrozoans

Sea Wasp

https://en.m.wikipedia.org/wiki/Chironex_fleckeri

https://en.m.wikipedia.org/wiki/Cnidocyte

Niacin

Pyridoxine

Inositol Nicotinate

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Cicada Fungus
Massospora
Entomophthoraceae
Zygomycota

https://en.m.wikipedia.org/wiki/Zygomycota

Trisporic acid is a C-18 terpenoid compound that is synthesized via β-carotene and retinol pathways in the zygomycetes.

It is a pheromone compound responsible for sexual differentiation in those fungal species.

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Thiamine
Inositol Nicotinate
Pyridoxal Phosphate
CD38

https://en.m.wikipedia.org/wiki/Inositol_nicotinate

https://en.m.wikipedia.org/wiki/Inositol

https://en.m.wikipedia.org/wiki/Pyridoxal_phosphate

https://en.m.wikipedia.org/wiki/CD38

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Indole
Vitamin B14
Pyrroloquinoline Quinone

https://valentinosnaturals.com/pqq-or-b14-what-is-this/

https://valentinosnaturals.com/citicoline/

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Inositol

Mannitol

Riboflavin

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B Vitamins
Indole
Indole-3-Carbinol
PQQ
Fenbendazole

Thiocyanate
Diindolylmethane
Allicin
Melanin

Vitamin B8: adenosine monophosphate (AMP), also known as adenylic acid. Vitamin B8 may also refer to inositol.

Vitamin Bm: myo-inositol, also called "mouse antialopaecia factor".

Alopecia areata is an autoimmune disease that attacks your body’s hair follicles, causing patchy hair loss.

Alopecia Inositol Nicotinate

The Biomedical Uses of Inositols: A Nutraceutical Approach to Metabolic Dysfunction in Aging and Neurodegenerative Diseases

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7554709/

Nature-inspired remodeling of (aza)indoles to meta-aminoaryl nicotinates for late-stage conjugation of vitamin B3 to (hetero)arylamines

https://www.nature.com/articles/s41467-020-19610-2

Synthesis of indoles

https://en.m.wikipedia.org/wiki/B_vitamins

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Vitamin B14
PQQ
Pyrroloquinoline Quinone
Methoxatin
Indole

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found an unusual link between Carbon, Nitrogen & Sulfur, its connections to B Vitamins, Allicin, Cannabinoids, Fenbendazole ect..

how it may be possible to use something like B1, B3 & MSM Mannitol to bind via highly acidic stomach acids, to produce Indole like compounds.

its almost impossible to explain, the chemistry "Cycles" are beyond difficult to track, the goal is using simple vitamin & supplements, to reach a very specific outcome.

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Exploring the Etiological Links behind Neurodegenerative Diseases: Inflammatory Cytokines and Bioactive Kynurenines

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7177899/

Picolinic Acid

https://en.m.wikipedia.org/wiki/Picolinic_acid

Pyridinecarboxylic Acida

https://en.m.wikipedia.org/wiki/Pyridinecarboxylic_acids

Sodium Thiosulfate

https://en.m.wikipedia.org/wiki/Sodium_thiosulfate

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Vitamin A Metabolism:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3042718/

Enzymatic Conversion of Proretinoid Carotenoid to Retinoid (Bcmo1)

this is how to reverse a weaponized endosymbiont fungal infection, ultimately a slime mold, capable of rewriting the DNA like a computer processor.

B1 B3 NAC ect..

this is the pathway used, so by slamming it, will force it to mutate.

phage is a nickname for a very complex parasitic element, with a thousand different names.
i makes almost no sense, with modern science definitions, because they hide the true nature of this Phage.

its more like a Endosymbiont Slime Mold, then a Virus.

this appears to be by slamming very specific B Vitamins, jamming the network.

its a very unusual critter, that must be studied very closely, not just anything will fix it, a very specific pathway it normally uses, must be slammed hard, forcing it to mutate back to immunity protective.

this is how to reverse a weaponized endosymbiont fungal infection, ultimately a slime mold, capable of rewriting the DNA like a computer processor.

may be useful for flipping enzymes, it seems to require a variety of things to make this happen, complex toxins to break up.

the idea is to breqk up tue biofilms & plaque using enzyme reactions, until it reaches the parasitic microbes, then binds it up & ultimately neutralized.

similar to mycoplasma fermentans, hides in bone marrow & makes toxic lipids, eventually leading to bone cancer.

flip the lipids back to the correct polarity & until eventually finds way to the mycoplasma itself.

ultimately there is no cure to weaponized mycoplasma & prion, but the enzyme metalloenzyme approach may be the ticket.

even still Garth is using or recommending lipid replacement therapy for mycoplasma infection, knowing its just an uphill battle to nowhere.

so my idea is incorporating his general plan, yet just flipping the toxic lipids already in the body, and ultimately making them unusable to the parasitic host.

just think today, normal B complex multivitamins do almost nothing, in comparison to what im testing lately.

newest idea is.. can B1/B3 together or even with NAC, can the most basic (powerful) B vitamins actually synthesize the other more complex B vitamins as they metabolize & trigger complex carbohydrate enzyme reactions?

look at how similar B3 & B6 are..

i think this B metabolism process has a huge part to do with Vitamin A, in relation to Lipid polarity, or the difference between healthy & toxic oils.

and B1, B2 & B6 transform Vitamin A, and B3 looks so similar to B6.

if im right, then it may be possible to pinpoint or reduce down the absolutely critical vitamin compounds to trigger all other vitamins, just unresolved state, or bound up in a sea of Lipid toxicity.

another fascinating tidbit, the addition of Inositol to B3 Niacin iz what makes it non-flush.

Inositol was thought to be another member of B Vitamins, Vitamin Bm: myo-inositol.

Inositol Mannitol (simple sugar)

its shape & structure looks very similar to B6, or B3 converts into B6 via Bm.

have another element to the testing of B1 B3 NAC MSM Vitamin C.

all of these are priming the body to go into Antioxidant & Enzyme, flipping toxic Lipids to the correct polarity.

but it "may" be capable of converting regular Castor or Coconut ouo into something like Vitamin E, D & Omega 3.

making regular healthy oils into powerhouse antioxidants, similar to Allicin.

its a combination of the Allicin & Lipid Replacement Therapy, but using regular good oils & the combination of the correct Heterocycle supplements, and the stomach will do the rest, apposed to trying to mix everything perfectly or correctly.

the B1 B3 NAC ect.. it will make my skin nice & oily for a couple days, then dry again, so it seems an oil is required, making it more like Allicin & Lipid Therapy.

the ultimate goal is to get the dangerous microbes, that specifically convert Lipid into toxic oxidants via hydrogen peroxide.

if things like mycoplasma & prion are using lipids to transform healthy cells, then spike the oil with the opposite polarity, via Heterocyclic compounds, Nitrogen & Sulfur & Minerals.

all the Bs, C, NAC & MSM, it is doing something very effective, but again it stops doing the enzyme thing, and then skin gets dry, so to keep the enzymes breaking things down may require an oil.

the idea is, Triglyceride & Heterocyclic together, may contribute to a full spectrum vitamin metabolite.

if it checks all the different cycles of enzymes for metabolism, then many or most of the vitamins will unlock with a normal diet, by using a couple of very specific elements.

if this is true, then it is likely also a cure to chronic diseases, because of the unlocked enzymes.
im fiddling with an idea, regarding how similar is Allicin & Lipid Replacement Therapy?

because a lot of corresponding data regarding the B1, B3, NAC, MSM & VC ect..

all that kind of stuff is antioxidant, like E, D & Omega 3.

my suspension is by taking the B & Cs with Castor Oil (Coconut, Olive), together will work like the Allicin & Lipid Therapy.

the Heterocycle parts of Nitrogen & Sulfur work together, but may actually require that pure oil (Triglyceride) to finish the enzyme reactions & flip toxic lipid into healthy ones.

because i am finding evidence that it does require oil to complete the complex enzyme activation reactions.

trying to bust things up, and need to figure gow to duplicate Allicin & Lipid Replacement Therapy, without any clue how.

im telling you, all of this weaponized Lyme, HIV, Prion.. all of it is some kind of mycoplasma plasmid/plastid technology, not a virus, and its damn near impossible to cure.

you seen all those chemicals manufactured by Mycoplasma Fermentans, all of those are the disease, the spike/prion is a living thing, or seed of something alive in mitochondria.

spliced west coast Chimpanzee liver malaria fluke symbiont plastid, into mycoplasma plasmid.

like an algae growing inside mitochondria, growing spike spores, misfolding proteins, mislabeled virus & prion.

to cure it requires to handle the mycoplasma biofilm toxins, break open the mycoplasma lipid biolayers hiding in bone marrow, blood cells, brain.. and do the same exact thing to the co- parasitic Protist hitching along and hiding inside mitochondria.

the bacteria is making toxic immuno-suppressive biofilm & the plastid is making amyloid hydrogel self assembling prions.

..

if you look at Methylene Blue & Fenbendazole, they are same near identical to B1 B3 B6 NAC MSM ect...

all i need it it to be close enough & the microbes will get smashed into compliance.

its fascinating how Fenbendazole, Methylene Blue, Allicin are almost the cure to all the same diseases that nobody can pinpoint down & cure.

something is missing, yet so close to the bulls eye.

they all have the same elements in common, Heterocyclic Compounds using Nitrogen Sulphur, enzyme reactions.. and something else, cant quite get yet.

havent taken the B vitamins is a few days, just testing the Castor reaction with them, it amplifies the sensations, being that B vitamins stay in the body for about a month, the oil seems to light them up.

havent taken any supplements in 4 or 5 days, and when i take a pop of the oil, all the strange zingy symptoms back, myst be triggering my liver to release the stockpile?

seems like Vitamin B3 is the simplest chemical structure, making it the first B vitamin position, B6 is the second & B1 as third.

by including the correct triglyceride, simple sugars should help convert B3 into 6, then with a Sulfur added becomes B3, via heterocycle assembling.

PHGDH & MTHFR gene disfunction with C677T & P53 causes B Vitamins metabolism disfunction, cancer & autism?

its some kind of Gene Knockout, from what i recall its from a bacteria plasmid or phage, is what caused so much autism?

its part of the One Carbon Metabolism process, that disrupts Folate & SAM, reminds me of the chemicals made by Mycoplasma Fermentans, almost like they found a way to transfer the bacteria plasmid into DNA, almost bypassing the mycoplasma itself, but what is this unusual plasmid?

and this is where i draw the line, is this a permanent DNA Knockout / Insert (not-alive), or is this actually a mitochondria symbiont DNA Parasite (alive).

Plasmid Plastid Protist Phage Prion Peptide

my point is depending upon the scientist specialty, any one of these are true, its all the same thing and nobody can see it.

i found that by using the B1, B3 (non-flush), NAC, Vitamin C, MSM ect... all the enzyme activators, mixed with a little Triglyceride, like Castor Oil, triggeres (or multiples) the enzyme Heterocyclic compound reactions, as if its converting it into the equivalent of Vitamin E, D & Omega.

its quite acstrong series of reactions going on, just a little oil goes a long way, too much makes more flushing sensations & really sleepy.

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XMRV (Virus) (VP62) Plasmid (Bacteria).. XMRV Bacteriophage?

Plasmid, Plastid, Phage & Carboxysome Microcompartments all looks like virus have been misidentified from a kind of endosymbiont Malaria, likely from Corallicolid, blended with mycoplasma fermentans, into Incognitus.

Neurotransmitter
Serotonin
B12
GABA
Dopamine
Folate
Methylation
Biosynthesis
Bioactivation
DNA Synthesis
B Vitamins
Thiamine
Niacin
Heterocyclic
Heterocycle
Heteroatom
Gene Mutation
Serine Metabolism
Serine Synthesis Pathway (SSP)
PHGDH (gene)
MTHFR (gene)
Methyl / Folate
SAM Cycling
Lipid Metabolism
Triglyceride
Polymorphism
Plasmid Plastid Protist Phage
P53 C677T

B Vitamins and the Brain: Mechanisms, Dose and Efficacy

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4772032/

B Vitamins in the nervous system:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6930825/

Folate and DNA Methylation:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3262611/

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PHGDH and its inhibitors for regulating cancer metabolism

Emerging evidence suggests that cancer metabolism is closely associated to the serine biosynthesis pathway (SSP), in which glycolytic intermediate 3-phosphoglycerate is converted to serine through a three-step enzymatic transformation. As the rate-limiting enzyme in the first step of SSP, phosphoglycerate dehydrogenase (PHGDH) is overexpressed in various diseases, especially in cancer.

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MTHFR (gene)

Methylenetetrahydrofolate reductase deficiency

Methylenetetrahydrofolate reductase (MTHFR) is the rate-limiting enzyme in the methyl cycle, and it is encoded by the MTHFR gene.

Methylenetetrahydrofolate reductase deficiency is the most common genetic cause of elevated serum levels of homocysteine (hyperhomocysteinemia). It is caused by genetic defects in MTHFR, which is an important enzyme in the methyl cycle.

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Methylenetetrahydrofolate (MTHFR), the One-Carbon Cycle, and Cardiovascular Risks

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8703276/

Allosteric inhibition of MTHFR prevents futile SAM cycling and maintains nucleotide pools in one-carbon metabolism

https://www.jbc.org/article/S0021-9258(17)50430-5/fulltext

Methylenetetrahydrofolate reductase and psychiatric diseases

https://www.nature.com/articles/s41398-018-0276-6

One-Carbon and Polyamine Metabolism as Cancer Therapy Targets

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9775183/

Is the MTHFR C677T variant a genetic risk factor in the etiology of autism spectrum disorder? Is it alone or by combined with rare variants of the PHGDH gene? Running Title: Is the MTHFR C677T a genetic risk factor for autism?

https://www.bibliomed.org/?mno=85003

Nutrigenomics and Nutrigenetics

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3481686/

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Pyrethroid

Developmentally exposed mice had disruptions in 116 metabolites which clustered into pathways for folate biosynthesis, retinol metabolism, and tryptophan metabolism.

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What The Science Says About B3 Vitamins And Methylation

https://www.aboutnad.com/scientific-analysis/what-the-science-says-about-b3-vitamins-and-methylation

Emerging Role of Nicotinamide Riboside in Health and Diseases

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9571518/

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Nicotinamide Riboside
Inositol Nicotinate

Simple Sugar:

Ribose
Inositol
Mannitol

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Sirtuin

Sirtuin activators and inhibitors: Promises, achievements, and challenges

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6342514/

The SIRT6 activators bind, independent from substrate, to the acyl channel and might induce an enzyme conformation with increased substrate peptide affinity as suggested by such kinetic effects of free fatty acids, which are assumed to also bind to the acyl channel

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Role of Sirtuins in Retinal Function Under Basal Conditions
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276360/

NAD+ and sirtuins in retinal degenerative diseases: a look at future therapies

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6235699/

Implications of NAD+ Metabolism in the Aging Retina and Retinal Degeneration

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7238357/

SIRT1, a histone deacetylase, regulates prion protein-induced neuronal cell death

https://www.sciencedirect.com/science/article/abs/pii/S0197458010003994?via%3Dihub

Sirtuins and Their Roles in Brain Aging and Neurodegenerative Disorders

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5357501/

A neuroprotective role of SIRT1 has been also observed in prion diseases.

..

i think one of the key goals is to get the Vitamin A flipped in the right direction, then the enzymes start working.

seems everything depends upon enzyme unlocking, specially with Vitamin A.

i dont think we need much A, but its the main malfunction that stops everything else.

found papers explaining..

B-Vitamins & NAC-Acetyl flip Retinol into Sirtuin.

NAD is required to manufacture SIRT, but Niacin inhibits this process by stealing the Methylation OH from the liver, and requires a simple sugar to neutralize.

Retinol toxicity is likely the dark pigments of Phosphorus, locked into toxic acids.

Resveratrol from grapes have only Phenol, while grapes naturally have Nitrogen & Sulfur.

Castor oil is allowing the simple B3 & B1 vitamins to morph into tue ither more complex B vitamins & Heterocycle compounds, drawing out the locked acid Phosphorus plaque from organs.

Phosphorus
Phosphate
Polyphosphate
Glyphosate

Hypervitaminosis A
Retinoid
Retinol
Retinal
Retinyl
Retinaldehyde

..

Efficacy and Safety of Inositol Hexa Nicotinate (IHN) in Improving Serum Lipid Profile in Patients with Low HDL Levels

https://www.medicalandresearch.com/current_issue/1565

The Last of Us: Ophiocordyceps

https://youtu.be/isFIv3-aHPY?feature=shared

how exactly does a Super-Prion event infect the entire world?

in ancient past, before vaccines, how did it spread so effectively?

insects, birds, fungus, comets?

is this global temperature rising & fungus mutation fact or fiction hypothesis? and any connection to Super-Prion events?

..

Do Amyloids Remember Their Origin? New Insights into the Prion Species Barrier

https://www.cell.com/fulltext/S1097-2765(04)00208-4

Extrapolation of these data to the mammalian systems represents a new major breakthrough, further underlining the similarities between yeast and mammalian prions.

..

The recent identification of a bacterial prion-forming protein suggests that bacteria also harbor prions.

prion-like proteins are involved in the interaction between phages and bacterial cells and postulate the possible association of prion-like domains with human diseases

..

the chemical that triggers a bunch of problems regarding yeast fungus toxins have to do with Vitamin A, flipped to the unusable form, builds up & lockes all other nutrients, only B Vitamins, Heterocyclic Compounds using Nitrogen & Sulfur & Triglyceride can unlock this enzyme lock.

Inositol is the part to make Niacin Non-Flush, by acting as CH3, it protects the liver from Methylation binding.

the MSM with Castor seemed to just make me sleepy, im really having good results with the Inositol Nicotinate & Castor.

looking threw comments of people experience with it & says keeps away the voices in severe schizophrenia.

the Inositol is non toxic to dogs & cats, and has neuroprotective properties, and calm OCD symptoms.

been testing IHN & NAC, with. a little shot of Castor. i think its behaving like Lipid Replacement Therapy, and it turns the Castor into the equivalent of Vitamin E antioxidant properties.

tried every different kind of combination, with everything else, its ultimately the Nitrogen to Sulfur, leaning towards more Nitrogen, with that special sugar alcohol CH3 Group, and unsaturated Triglyceride.

the Nitrogen & Sulfur is two sides of the enzyme zipper, the oil is the zipper flap that pulls it, and the special sugar protects the DNA from the enzyme reactions.

the minerals are part of the equation, but probably got enough of them, but if electrolytes are low, it would probably stop working as well.

took the Castor, Nician, NAC & Minerals today, first time trying with the Minerals in this combination.

for whatever reason, having tried this combination yet, see if it feels any different, cause normally the minerals dont seem to digest or dissolve all the way, is how the vinegar idea came along.

but the stomach acids can do the vinegar part all by itself, but with the other vitamins should actually do what its supposed to do, make enzymes.

any other combination would stop working over time, the enzymes reactions would stop, and i need them moving.

i suspect the toxic bile acids collect into bad phosphate like glyphosate in the liver & kidneys, and phosphorus needs to be triggered by good enzymes to make good protein & lipids.

and all of this is dependent upon the Protective Group in the Nician & NAC.

NAC = Acetyl
iHN = Inositol

and if all of this is correct, and works the way i think its working, it will convert the toxic phosphorus buildup into all the other vitamins along the chain.

meaning it will make Vitamin A, B1, B6, B9, B12, Vitamin C, Vitamin E & D.

vitamin B3 has a simpler structure then B1, makes me wonder if the numbers are mixed up, regarding the way they metabolize into other Enzymes, an even possibility into other vitamins via Heterocycle assembling, and even the water to oil solubility because of the Sulfur.

that second picture, see how Phosphorus is insoluble with minerals, that the part that gets toxic & blocked up, and needs to be unbound to make the other B vitamins function.

and all of this is because of Vitamin A being locked into a toxic form of acid, that also requires B vitamins to unlock.

Vitamin A & Phosphorus get locked & only the B Vitamins with a small amount of Sulfur, unsaturated Oils & Minerals can unlock.

the good Carbon & Hydrogen elements are the "Protective Groups".

and the way i knew it was the right combination, was because my dreams came back almost instantly, vivid & clarity.

..

the idea that by unlocking vitamin A will also unlock Phosphate from the liver & begin assembling all the restvof tye vitamins & fix the toxic acid buildup, that mycoplasma & cancer produces, and possibly a cure as well.

that old fella who discovered B1 was reversing genetic diseases, that was a big clue for what im trying, looking through his papers, he was also struggling with how eventually it stips working, and thats what im trying to figure out.

they discovered it was directly to do with Vitamin A & Phosphorus lock.

overall, the chemistry is damn near identical to Fenbendazole, Castor & Pine Terpinene.

The Terpinene is acting as the "CH3 Protective Group".

people with diabetes or dialysis cant have Phosphorus, Potassium or Vitamin A.

im almost assuming that Menthyl Nicotinate & Inositol Nicotinate will be the result of Niacin, Carbohydrate & Triglyceride.

meaning that Nician (Nitrogen) with an Oil & Sugar will ultimately be the same thing.

not sure how that will work out in real world application, testing the regular hot Nician together with Sugar & Oil?

..

CH3 Methyl Group
Acetyl vs Acetal

https://wikidiff.com/acetyl/acetal

https://en.m.wikipedia.org/wiki/Methyl_group

Methyl vs Menthyl

Phytogenic biosynthesis and emission of methyl acetate

https://onlinelibrary.wiley.com/doi/10.1111/pce.12164

Is the prevalent human prion protein 129M/V mutation a living fossil from a Paleolithic panzootic superprion pandemic?

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7030913/

Prion Glycoprotein: Structure, Dynamics, and Roles for the Sugars

https://pubs.acs.org/doi/10.1021/bi002625f

The structure of the infectious prion protein

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7030906/

The involvement of the skeletal muscles in long COVID-19

https://www.news-medical.net/news/20220418/The-involvement-of-the-skeletal-muscles-in-long-COVID-19.aspx

SARS-CoV-2, long COVID, prion disease and neurodegeneration

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9551214/

RNAs That Behave Like Prions

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7333576/

Thiamin and protein folding

https://www.sciencedirect.com/science/article/abs/pii/S0306987719300829?via%3Dihub

The prion protein binds thiamine

https://febs.onlinelibrary.wiley.com/doi/10.1111/j.1742-4658.2011.08304.x

Oligomeric-Induced Activity by Thienyl Pyrimidine Compounds Traps Prion Infectivity

https://www.jneurosci.org/content/31/42/14882

Prion propagation and inositol polyphosphates

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5949079/

..

A master of all trades – linking retinoids to different signalling pathways through the multi-purpose receptor STRA6

https://www.nature.com/articles/s41420-021-00754-z

Direct evidence of cellular transformation by prion-like p53 amyloid infection

https://journals.biologists.com/jcs/article/134/11/jcs258316/269011/Direct-evidence-of-cellular-transformation-by

..

Hypervitaminosis A
Retinol
Phosphate
Lipid Metabolism

DNA Methylation: A Promising Approach in Management of Alzheimer’s Disease and Other Neurodegenerative Disorders

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8773419/

The Roles of Vitamin A in the Regulation of Carbohydrate, Lipid, and Protein Metabolism

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4449691/

A Review of Current Evidence on the Relationship between Phosphate Metabolism and Metabolic Syndrome

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9656201/

Efficacy and Safety of Inositol Hexa Nicotinate (IHN) in Improving Serum Lipid Profile in Patients with Low HDL Levels

https://www.medicalandresearch.com/current_issue/1565

..

Telomere
Nucleoprotein
Telomerase Holoenzyme
Methylation
Acetylation
Ubiquitination

Ubiquinol
Ubiquinone

Histone Modifications and the Maintenance of Telomere Integrity

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6407025/

Telomere Dynamics and Telomerase in the Biology of Hair Follicles and their Stem Cells as a Model for Aging Research

https://www.sciencedirect.com/science/article/pii/S0022202X2032399X

Prion-mediated neurodegeneration is associated with early impairment of the ubiquitin–proteasome system

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4752964/

Sugar Alcohol
Polyol
Inositol
Mannitol
Terpineol
Terpene
Turpentine
Monoterpene

The Monoterpenoid Perillyl Alcohol: Anticancer Agent and Medium to Overcome Biological Barriers

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8709132/

..

Flea Powder (Spray)

Milbemycin
Oxime
Lufenuron

https://en.m.wikipedia.org/wiki/Milbemycin_oxime/lufenuron

Niacin
Citric
DMSO
Glycerol
Minerals

..

Renin Angiotensin System

Renin Angiotensin Aldosterone System (RAAS)

Renin (enzyme)
Angiotensin II (hormone)
Aldosterone (hormone)
Potassium (electrolyte)

https://en.m.wikipedia.org/wiki/Renin–angiotensin_system
..

Sugar Acid + Potassium
Potassium Acetate
Potassium Ascorbate

Potassium Hydroxide
Potassium
Hydrogen
Oxygen

Sulfite Toxicity
Metabolic Acidosis
MTHFR
Homocysteine
Sulfur Metabolism
Betaine Glycerin
Nitrogen Deficiency

Sodium Toxicity
Hypertension
Renin
Angiotensin
Aldosterone
Potassium Deficiency

Potassium Gluconate
Betaine Trimethylglycine
Sugar Acid (Vinegar Honey)

..

https://www.ahajournals.org/doi/full/10.1161/hypertensionaha.118.10267

https://www.scalpny.com/blog/does-potassium-help-with-hair-loss/

https://www.livingwithmthfr.org/genetic-education/amino-acids/s-adenosyl-methionine-same

..

Hydroxylation
Hydroxylases
Hydroxyproline
Xaa-Yaa-Gly
Glycosylation Collagen
Triple Helix

https://en.m.wikipedia.org/wiki/Hydroxylation

https://en.m.wikipedia.org/wiki/Hydroxylation_of_estradiol

https://en.m.wikipedia.org/wiki/Hydroxyproline

https://en.m.wikipedia.org/wiki/Triple_helix

..

Glycosylation Modulates the Structure and Functions of Collagen

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11012932/

Potassium Glutamate and Glycine Betaine Induce Self-Assembly of the PCNA and β-Sliding Clamps

https://www.sciencedirect.com/science/article/pii/S0006349520309012

Gluconate
Glucose Oxidase
Oxidoreductase

Glucose Oxidase, an Enzyme “Ferrari”: Its Structure, Function, Production and Properties in the Light of Various Industrial and Biotechnological Applications

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8946809/

..

Antihypertensive
Potassium Citrate
Calcium Oxalate
Thiazide

Lipid
Unsaturated Oil
Triglyceride
Fatty Acid
PUFAs
Methyl Group CH3

Fatty Acids Composition of Vegetable Oils and Its Contribution to Dietary Energy Intake and Dependence of Cardiovascular Mortality on Dietary Intake of Fatty Acids

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4490476/

PUFAs depending on the position of the first double bond from the fatty acid methyl-end. The human body cannot synthesize PUFAs with the first double bond on C3 and C6 from the methyl-end because of the absence of appropriate enzymes.

..

Methyl Group CH3 seems to be the exact point of disruption, from good to bad reactions.

meaning, this is how & where Vitamin A & Phosphorus lock the liver from processing, the very beginning of the enzyme chain reactions.. locked, and toxic acid overload & disease.

all disease seem to target the Lipids.

my suspension is that Niacin alone binds the Methyl CH3 from the remaining pool, so not very helpful, yet (IHN) Inositol Hexa Nicotinate is supplied with enough CH3 to flip toxic lipids back, and looking at CH3 in comparison to unsaturated Triglyceride, it appears to be the same general compound as CH3, or close enough to assist the lipid flipping.

this idea goes along what Garth was trying to do, with Lipid Replacement Therapy & Hydrogen Water Treatment.

unfortunately both of those are only therapeutic, what im trying is a cure, because as the lipids flip, eventually they will find the source of the disease, and kill it.

..

B Vitamins (Nitrogen/Sulphur) & C Vitamins (Citric), Essential Minerals & Castor or Olive Oil.

anything that can trigger "enzyme activator" reactions, to clear Vitamins A & Phosphorus blockages in liver, kidneys, gall bladder, bile duct.

the idea is, the body has the ability to handle any kind of disease, but the toxic acid parasitic fermentation & toxic pesticides block the enzyme process, locking immune system.

the viral diseases seem to be some kind of mitochondria parasite, that are capable of evolving to medications, only an active immune system is powerful enough to keep at bay.

Dopamine
Dopaminergic
Phosphorus
Phosphate
Retinoid
Retinyl
Esters
Retinol
Retinal
Liver

Dopaminergic Pathways

https://en.m.wikipedia.org/wiki/Dopaminergic_pathways

Retinoids in the Pathogenesis and Treatment of Liver Diseases

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9002467/

Retinoid X Receptor: Cellular and Biochemical Roles of Nuclear Receptor with a Focus on Neuropathological Involvement

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9015987/

..

it seems to be the outcome of all the different diseases, because it locks immunity.

immune suppressing microbes.

locks everything up.

specifically the Phosphorus, which is required for everything else to work.

things like Glyphosate & parasites ferment toxic Phosphate binding compounds, making what is vital into toxic waste.

..

Retinoid Receptor
Retinoic Acid Receptor
Retinoid X Receptor
Retinoid X Receptor Alpha
Retinoid X Receptor Beta
Retinoid X Receptor Gamma
Liver X Receptor
Related Orphan Receptor

https://en.m.wikipedia.org/wiki/Retinoid_receptor

https://en.m.wikipedia.org/wiki/Retinoic_acid_receptor

https://en.m.wikipedia.org/wiki/Retinoid_X_receptor

https://en.m.wikipedia.org/wiki/Retinoid_X_receptor_alpha

https://en.m.wikipedia.org/wiki/Retinoid_X_receptor_beta

https://en.m.wikipedia.org/wiki/Retinoid_X_receptor_gamma

https://en.m.wikipedia.org/wiki/Liver_X_receptor

https://en.m.wikipedia.org/wiki/RAR-related_orphan_receptor

..

testing my most recent idea, NAC, Castor Oil & Sea Salt.

its supposed to just get the enzymes moving along.

possibly some charcoal at different times to help detox.

every chronic disease seems to stem from Vitamin A Retinoid locked up, from toxic Phosphate lipids.

from pathogens to Glyphosate, liver & immune system locked from natural immunity.

after doing this little protocol, i began having dreams again, every night, and every nap, for weeks now.

what NAC seems to be doing is B & C Vitamins, the Castor keeps the enzymes moving along vis Methylation of Hydrogen, the Sea Salt are the Metalloenzymes.

everything is enzyme related, disease is blocked enzymes, gene knock-out.. enzyme locked.

and raw honey.

..

so everything is still pointing to caramelization of sugar, lemon, oil, sea salt, plus Nitrogen & Sulfur.

everything seems dependent upon the phosphate orientation, just not exactly sure how.

Lysine & Carnitine is also NAC, metabolize lipids in mitochondria.

so maybe breaks up the wrong forms of Phosphorus?

seems like anything that can break down Dioxins & PFAS forever chemicals, will break down toxic acid sludge from the body, specially Salt Bile Metalloenzyme & Nitrogen (Protease Enzymes).

Fulvic Humic acid, going to spike it with enzyme activators, Castor oil & sea salt.

this was the original plan 4 years ago, but tried to make my own Fulvic via Hemp seed fermentation, and it went bad, so the idea kind of got left in the dust.

caramelization of plant biomass & honey was along the same idea, for the enzymes to complete the breakdown process, every element needs to be available in its most monoatomic state, so the toxins reassembly binding is neutralized.

Succinate Dehydrogenase

Triglyceride
Cholesterol
Low/High-Density
Lipoprotein
HDL (Good)
LDL (Bad)
Saturated
Unsaturated
monounsaturated
Apolipoprotein A1 (apoA1)
CD36
Polyunsaturated
Fatty Acid
PUFA
Cytochrome P450

https://en.m.wikipedia.org/wiki/Cytochrome_P450

https://en.m.wikipedia.org/wiki/Cholesterol_25-hydroxylase

https://en.m.wikipedia.org/wiki/CD36

https://en.m.wikipedia.org/wiki/FYN

..

Succinate Dehydrogenase—Assembly, Regulation and Role in Human Disease

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2874626/

Making it or breaking it: DNA methylation and genome integrity

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7606623/

Methionine metabolism in chronic liver diseases: an update on molecular mechanism and therapeutic implication

https://www.nature.com/articles/s41392-020-00349-7

..

Enzyme Activator
Methylation
Methionine
Methyltransferase
Succinate Dehydrogenase

Enzyme Inhibitor
Methylmalonic Aciduria
Oxaloacetate
Malonic Acid
Malonate
Malate
Oxidative Phosphorylation

https://en.m.wikipedia.org/wiki/Methionine

https://en.m.wikipedia.org/wiki/Combined_malonic_and_methylmalonic_aciduria

https://en.m.wikipedia.org/wiki/Malonic_acid

https://en.m.wikipedia.org/wiki/Succinate_dehydrogenase

https://en.m.wikipedia.org/wiki/Oxaloacetic_acid

https://en.m.wikipedia.org/wiki/Methyltransferase

https://en.m.wikipedia.org/wiki/Oxidative_phosphorylation

..

Progress advances in the production of bio-sourced methionine and its hydroxyl analogues

https://www.sciencedirect.com/science/article/abs/pii/S0734975023001660

https://draxe.com/nutrition/l-methionine/

..

Lipidomics
Phosphoproteomics
Phosphoproteome

Phosphoglycans
Phospholipids
Oxidative Phosphorylation
Cardiolipin

RON Protein
RON13 Kinase

Alzheimers
Toxoplasmosis
Amyloidosis

Preventing the break-in of the toxoplasmosis parasite

https://www.sciencedaily.com/releases/2021/06/210624114321.htm

Semisynthesis of Functional Glycosylphosphatidylinositol Anchored Proteins

https://onlinelibrary.wiley.com/doi/10.1002/anie.202002479

..

Combined malonic and methylmalonic aciduria (CMAMMA)

ACSF3 Gene
Malonyl-CoA Decarboxylase Deficiency

Alpha-Lipoic Acid (ALA)
Acetylcarnitine (ALC)
Carnitine
Cardiolipin

Cardiolipin is a kind of diphosphatidylglycerol lipid. Two phosphatidic acid moieties connect with a glycerol backbone.

..

Assessing the antioxidant and metabolic effect of an alpha-lipoic acid and acetyl-L-carnitine nutraceutical

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8173094/

..

Phospholipid Composition of Membranes Directs Prions Down Alternative Aggregation Pathways

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2856143/

prion protein (PrP). PrP is glycosylphosphatidylinositol-anchored (GPI).

PrP is glycosylphosphatidylinositol (GPI)-anchored, it is closely associated with lipid membranes.

acidic phospholipids have been shown to promote protein misfolding and amyloid formation for a number of amyloidogenic and nonamyloidogenic proteins.

hydrophobic nature of the lipid membrane core, which promotes protein unfolding.

acidic membranes to neutralize positively charged clusters on the surface of proteins, which prevents repulsion between protein molecules and promotes oligomerization.

PrP binds to model membranes composed of palmitoyloleoylphosphatidyglycerol (1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoglycerol) (POPG).

..

l-lysine

https://www.healthline.com/health/lysine-foods#benefits

https://www.swansonvitamins.com/blog/articles/whats-the-difference-between-lcarnitine-and-acetyl-lcarnitine.html

..

Dioxin & PFAS Toxins

Dioxin
(Agent Orange)

PFAS
Forever Chemicals
(Teflon)

Sodium and potassium metal - these reduce and defluorinate PTFE

Boranes (Boron)
Nitric Acid
80% NaOH
Sodium Hydroxide
80% KOH
Potassium Hydroxide
Ammonia
Amines & Imines
Reductive Amination

PTFE is exceptionally sensitive to radiation. PTFE experiences significant damage at lower radiation exposure levels than other polymers.

..

Protease Enzymes
Enzime Activator
Bromelain
N-Acetylcysteine
Metalloenzyme
Fulvic Humic Acids

https://en.m.wikipedia.org/wiki/Protease

Therapeutic Potential of Fulvic Acid in Chronic Inflammatory Diseases and Diabetes

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6151376/

Pentose Phosphate Pathway

https://en.m.wikipedia.org/wiki/Pentose_phosphate_pathway

..

Fulvic Humic
Castor Oil
Sea Salt
Potassium Citrate
Honey
Vinegar

Enzyme Activator
NAC Niacin

Probiotics
Fermented Superfood

..

Brain glucose metabolism in schizophrenia

Glycine transporters as novel therapeutic targets in schizophrenia, alcohol dependence and pain

https://www.nature.com/articles/nrd3893

..

Lipid Metabolism
Trihydroxy
Sugar Alcohol
Menadione

Inositol
Glycerol
Triglyceride

K2
Menaquinone
Quinone
Isoprenoid
Plastoquinone
Ubiquinone

Niacin
Inositol

Lipogenesis
Glyceroneogenesis
Glycolysis
Glyceride
Acylglycerol
Pyruvate
Cytosol
Liver

Vegetable glycerin is made by heating triglyceride-rich vegetable fats, such as palm, soy and coconut oils, under pressure or together with a strong alkali, such as lye.

Glycerin Enzyme
Glycerol Kinase
Glycerol 3 Phosphate
..

WD40
Silicone Glycerol

Glycerin Density

Skim away the soap from the top of the mixture. When the mixture has cooled, the fat and lye should have coagulated into a soapy substance floating on top of a layer of glycerin. Use a slotted spoon to scoop away the soap and leave behind the pure glycerin.

..

Glyphosate
Glycerol-3-Phosphate
Dehydrogenase (DHA)
Oxidoreductase
Hydroxylation

dehydrogenase activity (DHA) in the soils enriched with glyphosate.

..

Redox Cofactors

Nicotinamide Adenine Dinucleotide

Common electron acceptors used by this subclass are NAD+, FAD, and NADP+. Electron carriers are reduced in this process and considered oxidizers of the substrate. Electron carriers are coenzymes that are often referred to as "redox cofactors."

NAD+ is mostly used in catabolic pathways, such as glycolysis, that break down energy molecules to produce ATP.

..

Glycerol vs Glycine:

Trihydric Alcohol
Three Hydroxyl (-OH)

Glycine: C2H5NO2
Amino Acid (Nitrogen)

..

Liver Health

Nicotinate Inositol
Glycerol Glycerin
Niacin Nitrogen
Methylation CH3

Magnesium Glycinate
Inositol Nicotinate
N-Acetylcysteine

Optimizing Health: A Deep Dive into Magnesium Glycinate, Inositol Nicotinate, and N-Acetylcysteine

https://revitalizewellness.org/blogs/news/optimizing-health-a-deep-dive-into-magnesium-glycinate-inositol-nicotinate-and-n-acetylcysteine

..

Phosphorus & Glycine gets locked by enzyme inhibitors.

by blocking up Glycine & Phosphorus in liver, ultimately disrupts the NAD ATP & Retinol health attributes.

..

RAGE AGE

https://en.m.wikipedia.org/wiki/RAGE_(receptor)

Glycoprotein
Glyphosate

..

Triglyceride
Glyceride
Glycerol
Glycine

..

Skin Health

Retinol
Hyaluronic Acid
Nicotinamide

..

Glycerol as a precursor for hepatic de novo glutathione synthesis in human liver

https://www.sciencedirect.com/science/article/pii/S2213231723001507

Somatic Cell

https://en.m.wikipedia.org/wiki/Somatic_cell

5-MTHF L-Methylfolate

https://en.m.wikipedia.org/wiki/Levomefolic_acid

Laminin

https://en.m.wikipedia.org/wiki/Laminin

https://en.m.wikipedia.org/wiki/Glycerine_acetate

https://en.m.wikipedia.org/w/index.php?title=Phosphatidic_acid&wprov=rarw1

https://en.m.wikipedia.org/w/index.php?title=Teichoic_acid&wprov=rarw1

..

Cellular PARylation
Poly(ADP-Ribose) Glycohydrolase
Glycosidic Ribose
Glycohydrolase (PARG)
Nicotinamide Riboside
DNA Damage Repair
Telomere Maintenance

Mitochondrial Glycerol-3 Phosphate Dehydrogenase (mGPDH)
Glycerophosphate

Nicotinamide Riboside, a Promising Vitamin B3 Derivative for Healthy Aging and Longevity: Current Research and Perspectives

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10459282/

Antifungal Action of Methylene Blue Involves Mitochondrial Dysfunction and Disruption of Redox and Membrane Homeostasis in C. albicans

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4780517/

..

Flavin Group
Methylene Blue
Aldehyde Dehydrogenase

https://en.m.wikipedia.org/wiki/Flavin_group

..

BLOO
https://trybloo.com

Salicylic Acid
Methylene Blue
Caffeine
Taurine
Baking Soda
Vitamin B3

Regrowing hair in androgenic alopecia with taurine, caffeine, and lactoferrin

Efficacy, Tolerability and Cosmetic Acceptability of a Growth Factors, Caffeine, Taurine and a Chelating Complex-Based Gel in Subjects with Hair Loss

Introduction: We evaluated efficacy, tolerability, and cosmetic acceptability of a gel containing growth factors, taurine, caffeine and iron chelating complex (GFmgel) in subjects with hair loss (AGA/FAGA, TE) in a real-life condition.

Synthesis and Charecterisation of Methylene Blue Derivatives

https://egrove.olemiss.edu/cgi/viewcontent.cgi?article=3426&context=etd

Methylene Blue
Methylthioninium
Dimethyl-Phenylenediamine
Thiazine
10-N-Carbamoyl

Flavin
PH Tester

Flavin Group
Anthocyanin
Anthocyanidin

pH Indicator
Mythyl Red
Phenol Phthalate
Phthalein Dye
Triarylmethane Dye

..

stumbled upon something last night, while testing the Fulvic & B vitamin thing.. if i also swish & spit out sea salt minerals for my teeth, it seems to trigger some kind a Chloride interaction, got me sneezing & could smell Chloride.

what i think is going on is the Fulvic = Flavin, and when the minerals absorbed into my teeth & gums, the Chloride was released via pH reactions.

Flavin is the core element to Methylene Blue type compounds, identical to liqud pH testing liquid dyes, but requires a Chloride to make it blue.

my test years ago using Pyroligneous acid (liquid smoke) is a Carbon Phenol, similar to Polyphenol but dangerous.

it almost exactly what im trying again now, using Fulvic Humic, except the manufacturing process is very different.

Pyroligneous Acid is basically Congo Red, and Fulvic Humic is basically Methylene Blue.

so i went the wrong direction straight off the starting line.

but used as a medicine, its the wrong pH polarity, blue & green is the right direction.

the very first idea was to ferment or steam (low cook) plant biomass into Fulvic, then that idea went astray with Pyroligneous acid, because they are so similar, yet oppsite polarity.

when Prion stain dyes conversation came up, i already knew the general idea, just previously chose red, instead of blue/green.

by adding extra B vitamins, also pushed the pH down, sea salt is neutral 7, so that wont actually fix it, needs pH up.

..

PH up (chemical) is simply potassium hydroxide.

PH down is any nitrate (potassium nitrate, sodium nitrate, ammonium nitrate, etc) mixed with sulphuric acid.

Sodium and Potassium Ions in Proteins and Enzyme Catalysis

..

MTHFR mutation/variant
C677T & A1298C

is this actually a gene knock-out from a parasitic symbiont, mislabeled as genetic disease?

anything regarding gene knockout, gene mutation or locked enzymes is a red flag for DNA mitochondria parasites.. in my opinion.

Vitamin E
Alpha-Tocopherol

Farnesyl
Gamma-Tocopherol Methyltransferase (γ-TMT)
Tocopherol Biosynthesis

An Update on Vitamin E, Tocopherol and Tocotrienol

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6257355/

Vitamin E function and requirements in relation to PUFA

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4594047/

Tocopherols and Tocotrienols in Common and Emerging Dietary Sources: Occurrence, Applications, and Health Benefits

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5085773/

Methyltransferases: Functions and Applications

https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/cbic.202200212

..

"More than 60 years ago, a vitamin E deficiency was known to cause a brain disease, sometimes associated with sterility and muscular dystrophy. The symptoms of the brain disease were similar to those of “mad cow disease,” and the condition is now usually called “crazy chick disease.” Veterinarians are usually taught that it is caused by a selenium deficiency, but it is actually the result of an excess of PUFA in the diet, and is exacerbated by increased iron or other oxidants, and prevented by increased vitamin E, selenium, or substitution of saturated fats for the unsaturated."

..

MTHFR mutation/variant
C677T & A1298C

CH3
Methylation
Methylene
Methionine
Methyltransferase
Methylcobalamin
Trimethylglycine
Methylfolate

..

MTHFR Genes C677T vs A1298C

https://mthfrgenehealth.com/mthfr-genes-c677t-vs-a1298c/

MTHFR Gene Mutations Correlate with White Matter Disease Burden and Predict Cerebrovascular Disease and Dementia

Epigenetic Factors in Late-Onset Alzheimer’s Disease: MTHFR and CTH Gene Polymorphisms, Metabolic Transsulfuration and Methylation Pathways, and B Vitamins

C677T, A1298C, and A1793G polymorphisms on the age at onset, plasma homocysteine, and white matter lesions in Alzheimer's disease

..

Hyperhomocysteinemia: Clinical Insights

https://journals.sagepub.com/doi/full/10.1177/1179573520962230

Homocysteine & MTHFR

https://mthfrgenehealth.com/homocysteine-mthfr/

Homocysteine Disfunction
Hyperhomocysteineaemia
Alcohol, Tobacco, Caffeine
pH Homeostasis

Excessive:
Alcohol, Coffee or Tea
Smoking
Lack of exercise
High salt intake
High fat diet (red meat)
High-fat (dairy)

..

Levomefolic
Methylfolate

Medical foods for lowering homocysteine in hypertensive patients

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9832224/

KEY INGREDIENTS: L‐METHYLFOLATE, RIBOFLAVIN, AND NAC

Homocysteine Reduction

https://www.lifeextension.com/protocols/heart-circulatory/homocysteine-reduction

The Complete Guide to Folic Acid, Folate, and L-Methylfolate

https://www.seekinghealth.com/blogs/education/the-complete-guide-to-folic-acid-folate-and-l-methylfolate

Pteroylpolyglutamate

Pteroyl: polycyclic heterocyclic acyl radical

Acetate Revisited: A Key Biomolecule at the Nexus of Metabolism, Epigenetics and Oncogenesis—Part 1: Acetyl-CoA, Acetogenesis and Acyl-CoA Short-Chain Synthetases

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7689297/

What The Science Says About B3 Vitamins And Methylation

https://www.aboutnad.com/scientific-analysis/what-the-science-says-about-b3-vitamins-and-methylation

..

Tocopherol (Vitamin E)
Trimethyltridecyl

Trimethylglycine (TMG)
Betaine Anhydrous

https://en.m.wikipedia.org/wiki/Betaine

https://en.m.wikipedia.org/wiki/Trimethylglycine

Betaine vs. TMG

https://thisvsthat.io/betaine-vs-tmg

..

Homocysteine levels in schizophrenia and affective disorders—focus on cognition

Investigation of betaine as a novel psychotherapeutic for schizophrenia

..

how exactly does half the population have MTHFR mutation/variant C677T & A1298C?

and why does this seem to be the major malfunction, in the B6 enzyme?

after learning about this, im again strongly suspicious of Candida being more of a slime mold symbiont of coral.

its more intelligent then justva fungus, aquires data & evolves, relocates around the body, and may be the true origin of MTHFR Polymorphism.

Candida ≈ Lyme

still dont think Candida is just a yeast, but a symbiont, meaning it can use yeast & mycoplasma as vectors.

its doing the same kind of thing, just slower, makes me think its generally the same critter.

Candida Cordyceps
Amoebae Amoebozoa

like a single unit fused together inside our neurological systems, manufacturing MTHFR Gene Mutation.

Candida Hyperparasite coinfection is the Cordyceps of mammals.. thats the general idea.

if a corpse is let to decompose, would this Prion grow into Candida Cordyceps spores?

seems like Candida behaves differently outside vs inside the body, Covid, Lyme, GWS, HIV are inserts into Candida, and therefore instant access to our neurological systems.

wonder if the MTHFR Homocysteine B6 enzyme lock has anything to do with Amyloidosis, Prion Hydrogel Peptides ect..

Amyloids and yeast prion biology

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7321840/

..

MTHFR Gene
Mutation/Variant:
C677T & A1298C

Homocysteine Disfunction
Hyperhomocysteineaemia

Trimethylglycine (TMG)
Betaine Anhydrous

..

Yeast is a Beast – The MTHFR and Candida Connection

https://www.beyondmthfr.com/yeast-is-a-beast-the-mthfr-and-candida-connection/

..

Hyperparasite
Endoparasitoid
Dictyostelid Pathogen
Cellular Slime Mold
Symbiont Endosymbiont

Candida Cordyceps
Amoebae Amoebozoa
Cavenderia Aureostipes
Physarum Polycephalum
Toxoplasma
Mycoplasma

https://en.m.wikipedia.org/wiki/Physarum_polycephalum

..

https://en.m.wikipedia.org/wiki/Symbiodinium

https://en.m.wikipedia.org/wiki/Aiptasia

https://en.m.wikipedia.org/wiki/Myxozoa

https://en.m.wikipedia.org/wiki/Polypodium_hydriforme

https://chrismasterjohnphd.substack.com/p/mthfr-protocol

https://novoslabs.com/frequently-asked-questions/other-supplements/why-does-novos-use-glycine-instead-of-trimethylglycine-tmg-or-betaine/

https://examine.com/supplements/betaine/research/

Choline Inositol

Phosphatidylcholine
Lecithin

Trimethylglycine (TMG)
Betaine

TMG is a more downstream molecule in methylation pathways. We therefore recommend to take more upstream methylators, like choline and/or phosphatidylcholine (that way, the body can choose itself how much methylation donors it wants to create).

..

Effects of Dietary Resveratrol, Bile Acids, Allicin, Betaine, and Inositol on Recovering the Lipid Metabolism Disorder in the Liver of Rare Minnow Gobiocypris rarus Caused by Bisphenol A

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9973200/

..

Nicotinamide Mononucleotide

Glycine Glycerol Inositol

Inositol Nicotinate

..

looking at people using TMG & NMN together with great results, but it very delicate & need to be refrigerated & expensive.

i got some TMG today and chewed it up, tasts just like Glycerol.

come to find out its all basically just different forms of Glycerol that keeps Niacin from causing Methylation problems.

vitamin E has the CH3 as well, but not exactly sure its the correct thing.

the Fulvic Humic Acids did not work properly with the pH alkaline, so thats not the right direction, but regular Vegetable Glycerin seems ok so far.

i added some B1 & B3 to it as well, and also seems good so far.

concussion today is, the vegetable Glycerin is assisting the enzymes, and the recipe is..

one bottle of Humic/Fulvic

2 tablespoons of
Glycerol/Glycerin

one tablespoon of each..

B1 Thiamine
B3 Inositol Nicotinate
NAC
MSM

because it does seem the Fulvic is covering all of the important minerals & Carbon derivatives, just need something to bump it up, into a legitimate medicine, hopefully similar to a Fenbendazole kind of thing, with very little danger of side effects, except maybe loose stool.

Glycerol is the backbone to fatty acids, from Glyceride into Bi-Triglycerides.

what this tells me is it splits things like an enzyme, in conjunction with Nitrogen & Sulfur splits into enzymes.

the goal is to break up Homocysteine B6 Histamine lock.

this is exactly what B1 was found to do, but eventually stops working, the discovery from garlic & how its separated from Allicin.

possibility the secret to Allicin is not the chemical similarly to DMSO, but some kind of Glycerol conjunction with Sulfur.

without Vitamin B Complex, specifically B1 B2 B3 B6 B9 B6, the other vitamins convert into toxic acids, specially A & C.

Vitamin A
Hypervitaminosis A

Vitamin C
Oxalate Acid (Kidney Stones)

if Homocysteine & Histamine levels are too high, then all the B Vitamins become locked & also convert into toxic acids, Requiring Methyl Donors CH3, from something like Betaine Anhydrous.

..

looking at the B Vitamins, the order seems wrong, and all together seem to assemble B12.

1 = B3
2 = B6
3 = B1
4 = B2
5 = B9
6 = B12

Vitamin B4:
Adenine
Carnitine
Choline

Vitamin B8:
Adenosine Monophosphate
Inositol

Vitamin B10
Para-Aminobenzoic Acid

Vitamin B11:
Salicylic Acid

..

https://wonderlabs.com/whatever-happened-to-vitamins-b4-b8-b10-and-b11

..

wondering if any similarities?

Nattokinase
Allicin
Betaine
Inositol

wondering if this B Vitamin enzyme lock of Homocysteine, is ultimately a general lack of this simple Glycerin component, just to move blocked reactions along?

highest sources of both Thiamine & Betaine is bran/wheat germ.

..

The Metabolic Burden of Methyl Donor Deficiency with Focus on the Betaine Homocysteine Methyltransferase Pathway

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3798916/

..

still trying to understand exactly what a Methyl Doner even is, by looking at the chemistry of CH3, it appears to just be a Hydrogen/Proton doner, going right back to Garth using Hydrogen Water & Lipid Replacement Therapy, basically the same thing.

Hydrogen is the ultimate enzyme activator, because its the smallest atom.

Methionine
Folate
Betaine
Choline
Methyltransferase

Methyl Doner CH3
Betaine

Methionine
Methylene Blue

..

Vitamin A & C are dependent upon B vitamins, which is dependent upon Folate & Betaine to complete B12, and B is dependent upon the Citric Acid Cycle, which is ultimately Acetate or Acetic Acid or Vinegar that is found inside the mitochondria of young children.

i noticed the B Vitamins & with Betaine was not as effective, so i drank a strong lemon water, and it super charged the B, so then a strong cup of vinegar water, that really charged everything up, and found the scientific papers explaining this process.

Vinegar (Carbon)
Minerals (Ions)
B Vitamins (Nitrogen)
MSM (Sulfur)
Fulvic/Humic (Carbon)
Glycerol

my cold came back, second week now, none of the new ideas helped, so after about 6 months without the vinegar (chelate) minerals, i tried it again.

apple cider vinegar, multi minerals, niacin & glycerin.

it was the regular hot cheap niacin, almost went into a flush, but it may have been the vegetable glycerin that turned it into a body rush instead.

if im feeling better tomorrow, then its going in my notes as a flu killer.

..

i have noticed how, or it seems to me, they have somehow fused Covid-HIV spike with Candida, and skin problems.

for example, if my athletes foot is knocked down, it will almost instantly go the the oppsite foot toe, and start itching.

it seems like what was somewhat normal yeast problems, have been converted into some kind of pathogenic network system (or complex).

..

the way cancer, yeast & parasites thrive in acidic environments, vinegar minerals may appear acidic, but do the oppsite, via chelate absorption & alkalinizing.

with the synergy between B Vitamins Nitrogen, Sulfur & Glycerol, with the Carbon acids, Carbonic, Acetate & Citric Acid Cycle.

..

its not so much that it kills the parasites, but it slowes them down via microtubule channels, and boosts the immune system.

acetic makes minerals into a very powerful acetate, requiring very little minerals.

problem is trying to simplify my personal recipe, for someone else to duplicate, who dosnt have all the ingredients, so i should just explain my own recipe.

vinegar (apple cider 32 oz)

multi mineral complex (tablespoon)

sea salt (teaspoon)

niacin (teaspoon)

msm (teaspoon)

raw honey (tablespoon)

probiotics

coconut oil
vegetable glycerin

minerals & salt add little at a time as it expands via acid/base reactions.

got to leave the vinegar lid loose for a week or so, as it finishes fermentation & expanding.

coconut & vegetable glycerin, what does not desolve forms at the top, after fermentation, pour the top oil off.

in my opinion, niacin & msm cover all the b vitamins.

then a shot of that in the Fulvic/Humic acid, is my current setup, and it works.

the approach is different then vitamin or supplement, its not to give any specific nutritional benefit, but specifically to break up toxic blockages via enzymes activators, then vitamins can actually work.

the charged ions slow down parasitic microbes, and speed up natural immunity.

slows down parasitic microbes via microtubule gateways & parhways, our biology being much larger is faster at processing ions.

it kind of like making Chloroquine, Ivermectin, Fenbendazole, Suramin, Allicin, Methylene Blue & Betaine, by just using Vinegar, Honey, Sea Salt, Glycerol, Niacin & MSM

to duplicate them all, using raw materials, and allowing the body to manufacture the correct outcome.

with the honey, i also add premo probiotics to it, mix it in, and the vinegar does ferment along the way, to complete the complex Carbon elements.

the body requires nitrogen & sulfur for carbon carbohydrate metabolism, yet requires vinegar to kickstart the enzyme reactions.

nitrogen sulfur at equal amounts, the vinegar with a little extra minerals & raw honey.

Glycerol CH3 Methyl Doner keeps the nitrogen from getting hot, protecting kidneys & DNA.

Non-Flush Niacin, Thiamine, MSM, DMSO, Betaine, Inositol

Glycerol Vinegar
Diacylglycerol Oil

..

been tucking away most ideas, until the picture locks in place.

the cure to disease & parasites, chemistry sure does look like location of the mitochondria that heals & protects DNA.

its almost like disease is locking the same enzymes that metabolize vitamins in cells.

its difficult to explain, but all of the most powerful medications, for all kinds of diseases, look like the same mitochondria enzime lock, that determines health & sickness.

its like disease is a mitochondria symbiont hyjacking the enzyme reactions of one very specific spot.

testing Thiamine for a few months, and the conclusion is very close, but something missing to get all the enzyme moving along.

the chemistry is so complex at this location, trying to simplify the exact vitamins & enzyme activators.

unlocking the enzymes is the key.

..

what i found interesting is the series of enzyme locks, a repeating pattern at the same locations across so many diseases.

all seeming dependant upon one-carbon metabolism, locks all the other vitamins into toxins.

so far, the only thing that seems to work is..

Niacin with Inositol so to offer methyl CH3, MSM, Mineral complex for metalloenzyme reactions.

and the only thing that seems to activate this is by putting all of them in vinegar.

for some reason the Nitrogen & Sulfur act as a zipper, unzipping toxic acid buildup.

been trying to specify target things like Mycoplasma Fermentans (Incognitus) & Prion Amyloidosis.

recently noticed the Vinegar & Niacin (Inositol/Betaine) idea is similar to Creatine, (methylguanidine-acetic acid).

from what i can figure, its some kind of synthetic mycoplasma bound to a symbiont Alopaecia, causing so much chronic diseases?

and like what you say, the toxic foods & pesticides, but thats also similar toxins these microbes produce, inside mitochondria.

im no longer trying to kill, but more like focus upon the very exact microtubule pathways & binding mechanics.

Prion for example, match exactly what it wants, except bound to minerals ions that will ultimately make it slower then the bodys immunity, bind & swell it up until the immunity can recognize it.

mycoplasma for another example, has to more do with Lipids, making them toxic, so by enzymes breaking down the toxic acid buildup, then eventually it will break down the Lipid membrane of the mycoplasma.

well, not use any kind of actual medication, poison or antibiotic, but to use enzymes, mineral ions, to slow & swell the critters, so becoming resistant to treatment is impossible, because the molecular binding is smaller then the target.

..

it almost seems as if Osmolyte Mythyl Donor is the nitrogen with sugar alcohol with the vinegar that can carry the mineral ions into parasitic microbes.

parasitic yeast & bacteria seem to use Glyceric Acid or Glycolipids without Nitrogen, so do extremophiles, similar to antifreeze.

mitochondria parasites may be responsible for immortal cell rewriting of misfolded telomeres.

the Vinegar & Honey are giving interesting results, all this time never understood the secret of enzyme reactions.

Metalloprotease
Metalloenzyme

vs

Osmolyte
Methyl Doner

which is more important per ratio, salts or carbohydrates, to be broken down with vinegar into simplest compounds?

im beginning to see how its the complex carboxylates, and less salts.

..

vinegar, honey & glycine.

seems stupid simplistic, but its doing something beyond what science has figured out.

reading through the data, had to make my own conclusions.

Naturally occurring osmolytes are one of the most potent stabilizers for many proteins and are capable of reversing protein misfolding and/or aggregation, which are known to be underlying cause of several diseases.

tried all the Niacin, Thiamine, Betaine, DMSO, Mineral Ion combinations, all that stuff, and it was working alright, but this new snake oil lit all that that stuff up, literally, it triggered all the Nitrogen accumulated in my kidney & liver, triggered all kind of enzyme reactions, good luck going to sleep testing that stuff, up all nigjt buzzing with energy, from 8 hours after taking a shot.

vinegar, honey, vegetable glycerin, mixed in a cup of water to delute.

searched this combination of ideas on Twitter, dosnt seem to publicly aware of this, so if you can get an understanding of the general idea, you will be ahead of the curve, even the papers dont exactly know why osmolytes unfold misfolded proteins.

matched up the most effective osmolytes into a list, looking at the chemistry for repeating patterns, more clues.

two of the most unique & powerful osmolytes are nearly identical to Thiamine, when put together.

Trigonelline (Nitrogen)

Dimethylsulfoniopropionate (DMSP / Sulfur)

and basically what its doing is going into the backbone of protein via amino acid reconstitution, because its smaller then the molecule itself, unfolds it & makes it viable again.

Methyl Doner CH3 is not a Nitrogen, but a Carbon & Hydrogen reaction, the reason its so effective, is because Hydrogen (Proton) is the smallest atom, and can pedetrate any other molecule compound bonds, and reshape the foundation from the core or backbone.

oh, and ..

Osmolyte & Methyl Doner CH3 are basically the same thing, interchangeable idea.

Glycerol or Acetate alone does nothing, together is called Glycerine acetate, usad as a fuel addictive, it does nothing, it seems to require other "things" to make the enzymes continue operating, specially when a chemical lock occurs.

this is why honey & minerals comes to play.

Honey offers complex Organic Acids.

Minerals help Metalloenzyme operations.

Metalloprotease
Metalloenzyme

vs

Osmolyte
Methyl Doner

which is more important per ratio, salts or carbohydrates, to be broken down with vinegar into simplest compounds?

im beginning to see how its the complex carboxylates, and less salts.

another conclusion is that while Nitrogen, Sulfur & other elements are required to cascade enzyme reactions, we already have enough from food, gut & liver reserves.

excess Niacin, Thiamine or MSM may enhance the reactions, but may not be critical as the other three ingredients put together.

the Vinegar & Glycerol is very potent, even without adding all the other things, very little required of the extras.

seems to trigger the similar reactions as high dose Thiamine.

way too much honey, without time to ferment down, is probably not a great idea, seems to spike blood sugar in funny ways.

Creatine & Osmolyte are not attributed to a cure to any chronic disease, nor is niacin, vinegar, or minerals.. none of it.

everything needs to be triangulated, to a very specific point, meaning the same cure to LYME, HIV, Prion ect.. all the most terrible diseases, they have something in common that science is not able to explain.

the way Thiamine & Ivermectin are insecticides, reminds me of this Osmolyte pathway, Salt/Sugar with a Nitrogen, insect draws blood & it begins to ferment & manufacture Carbon Diox & Nitrogen Oxide, which is good for mammal Vascular systems, and not for Invertebrate.

this is the same explanation to explain how mitochondria parasites swell & become paralyzed for immune system identification.

..

getting mixed feedback regarding Methylene Blue & DMSO being toxic, likely because of the Sulfur.

this article talks about Glycerol being used as a non-toxic alternative for DMSO for Cryogenic applications, meaning it can likely be an absorbent in a similar way.

and capable of refolding proteins from the hydrogen backbone from salt ions, polyol from proto fatty acids & lipid formation.

dont exactly know how to do this trick yet, its obviously not just Creatine, or Glycerol, but it something in that direction.

needs..

Polyol
Nitrogen
Minerals

Osmolyte
Methylamines
Inorganic Ions

whats fascinating is the Polyol Sugar Alcohol & Inorganic Ions are dependent upon each other to pH balance the Osmolyte Pathway.

together they manufacture Amino Acids, Enzymes, Proteins, Fatty Acids & Lipids.

Chelated Minerals
Acetate Vinegar

Metalloprotease
Metalloenzyme

Protease
Proteolytic Enzyme

protease enzyme for hydrolysis of peptide bonds in protein.

..

Chelated amino acids: biomass sources, preparation, properties, and biological activities

https://link.springer.com/article/10.1007/s13399-022-02333-3

..

Glycerol Monostearate

https://en.m.wikipedia.org/wiki/Glycerol_monostearate

https://en.m.wikipedia.org/wiki/Stearic_acid

https://en.m.wikipedia.org/wiki/Palmitic_acid

..

Carbon-Hydrogen Bond Activation

https://en.m.wikipedia.org/wiki/Carbon–hydrogen_bond_activation

https://en.m.wikipedia.org/wiki/Borylation

..

Methyl Group

Novel Role of Molecular Hydrogen: The End of Ophthalmic Diseases?

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10674431/

..

Alpha-tocopherol: roles in prevention and therapy of human disease

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361124/

..

Amide Hydrolysis

Carboxylic (Vinegar)
Amine (Niacin)
Amide (Peptide)

NAD
Retinol Dehydrogenase

https://en.m.wikipedia.org/wiki/Retinol_dehydrogenase

https://en.m.wikipedia.org/wiki/Amide

https://en.m.wikipedia.org/wiki/Carboxylic_acid

Understanding Retinol Metabolism: Structure and Function of Retinol Dehydrogenases

https://www.jbc.org/article/S0021-9258(19)74831-5/fulltext

..

Glycerin
C3H8O3

Inositol
C6H12O6

Octanoic Acid
C8H16O2

Medium-Chain Fatty Acids (MCFA)

Medium-Chain Triglycerides (MCT Oil)

C8: caprylic acid or octanoic acid

C10: capric acid or decanoic acid

fractionated oils are great sources of medium-chain triglycerides (MCTs), providing fatty acids that contain 6 to 12 carbon atoms.

..

ALDH
Aldehyde Dehydrogenase

https://www.hormonesmatter.com/ttfd-thiamine-derivative/

https://living-whole.org/2022/01/19/considering-a-mega-dose-b1-approach-to-reversing-chronic-conditions/

Dietary methyl-consuming compounds and metabolic syndrome

https://www.nature.com/articles/hr2011133

Oxalate: A Potential Contributor to Hypervitaminosis A

https://www.hormonesmatter.com/oxalate-a-potential-contributor-to-hypervitaminosis-a/

..

https://en.m.wikipedia.org/wiki/Creatine

https://en.m.wikipedia.org/wiki/Heterocyclic_amine

..

Bile acids and salt-sensitive hypertension: a role of the gut-liver axis

https://journals.physiology.org/doi/full/10.1152/ajpheart.00027.2022

HOW HISTAMINE AND SULFUR ARE RELATED

https://www.drlaurendeville.com/how-histamine-and-sulfur-are-related/

MONROE INSTITUTE OF APPLIED SCIENCES PRESENTS THE GATEWAY PROGRAM

https://www.cia.gov/readingroom/document/cia-rdp96-00788r001700210040-8

https://www.vice.com/en/article/v7e4g3/found-page-25-of-the-cias-gateway-report-on-astral-projection

Universal Hologram
Electric Universe

in my opinion, Jesus is ourselves with full awareness, from outside of this isolation chamber or animal kingdom.

Simulation Theroy (TRON or Materialism) is misleading away from the true electrical holographic matrix.

Cubing Perception, Spectral Lines of Polarized Light & Harmonic Resonance of a Cube

a very narrow band of frequencies harmonic to that of a cube with 6 mirrors and 8 points, an illusion of infinite flat plane.

Sine Wave vs Square Wave

square waves of a box create sharp edges of distorted frequencies, morphing into complex triangle & saw waves, create even/odd harmonic resonance, or spectral lines of perception, capable of holographic oscilloscope illusion upon a flat plane.

sine waves are always round and full spectrum harmonic, more similar to Icosahedron of 12 faces & 20 points, and a dot in the center point triangulates the super-octive.

this super-octive is an atom.

to become one of the gods, as if that is ultimately the goal, or become God, in my opinion that is a satanic twist from logical mathematical networks, into illogical thinking.

so im just borrowing the CIA & Monroe Institute data points, not how to become a god, or riddled with demonic spirits with that as the primary objective.

wanting to be "God" is like trying to literally become a nuclear power plant running a mega-city infrastructure & the satellite & internet systems, all in one, plugged directly to your brain.

its a stupid idea, the most we can ever expect is access to a soul, heavenly realms & universal data streem, essentially like an angel of God.

not "a god" or literally God, its just stupid.

imagine being responsible for every blood cell & metabolic reaction in uour body, at all times, and every other lifeform in the universe, at all times, thats for the true God..

not some satanic pizza cult small hat wizard small g wannabe.

..

so they used Covid to poison our military, medical, police, and all forms of infrastructure personnel, while bringing in immigrant mercenaries can replace them.

BLM, Antifa, fentanyl, housing prices, unemployment, black rock housing & fire arm seizure to collapse into very specific sanctuary cities, preparing a void to be replaced by 3rd world gangs into police, while not required to vax.

all of this funded by stolen taxes, printing endless debt money, decapitation drugs, human trafficking children.

Corallicolid Plastid
Apicoplast

Apicoplast hosts important metabolic pathways like fatty acid synthesis, isoprenoid precursor synthesis and parts of the heme biosynthetic pathway.

https://en.m.wikipedia.org/wiki/Apicoplast

..

Prion Protein (PrP C) is a Glycosylphosphatidylinositol (GPI)-anchored glycoprotein on the cell surface.

..

Corallicolids: The elusive coral-infecting apicomplexans

https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1009845

These new intracellular parasites are members of the Apicomplexa, well known as parasitic agents of humans and other animals (Toxoplasma, Cryptosporidium, or the malaria agent Plasmodium) and are now called Corallicolida

..

Apicomplexa
Corallicolid
Glycoprotein
Prion

The Elusive Mitochondrial Genomes of Apicomplexa: Where Are We Now?

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8554336/

..

Apicomplexa
Marosporidia
Archigregarinorida
Opisthosporidia
Corallicolida

https://en.m.wikipedia.org/wiki/Apicomplexa

https://en.m.wikipedia.org/wiki/Microsporidia

https://en.m.wikipedia.org/wiki/Microsporidiosis

https://en.m.wikipedia.org/wiki/Centrosome

..

Microsporidia: a new taxonomic, evolutionary, and ecological synthesis

https://www.cell.com/trends/parasitology/fulltext/S1471-4922(22)00110-6

Their physiologies confer specialised parasitological characteristics, including the potential to remain latent in hosts for many years, jumping host species, taking advantage of sex, cannibalism, and other host behaviours to transmit, persisting in the environment for long periods of time, and masking themselves from their hosts' immune defences.

..

may be mistaken, but there is very little Corallicolid data online, and nobody seems to know what it does.

thats what im thinking. the spike / prion is the Carbon element to coral reef formation, that holds the Calcium like a elemental glue.

an unknown kind of Maleria that lives inside Coral Reef, responsible for the majority of Oxygen production for the planet, and nobody know anything about it, just some random mystery.

Naturally occurring osmolytes are one of the most potent stabilizers for many proteins and are capable of reversing protein misfolding and/or aggregation, which are known to be underlying cause of several diseases.

Osmolytes represent different chemical classes that occur naturally such as amino acids (proline and glycine), methylamines (betaine and trimethylamine-N-oxide), and polyols and sugars (sorbitol and sucrose).

amino acids (notably proline), tertiary sulfonium (dimethylsulfoniopropionate (DMSP)) and quaternary ammonium compounds (e.g., glycine betaine, proline betaine (also known as stachydrine), β-alanine betaine, pipecolate betaine (also known as homostachydrine), hydroxypipecolate betaine and choline-O-sulfate, trigonelline (nicotinic acid betaine)), sugar alcohols (mannitol, sorbitol, pinitol).

..

natural sources of amino acid vinegar fermentation

Nutrients and bioactive components from vinegar: A fermented and functional food

https://www.sciencedirect.com/science/article/pii/S175646461930605X

..

Osmolyte
Osmoregulation
Methyl Doner

Inositol
Betaine

MDCK
Glycerophosphocholine

What’s New About Osmotic Regulation of Glycerophosphocholine

https://journals.physiology.org/doi/full/10.1152/physiol.00009.2009

Intracellular Organic Osmolytes: Function and Regulation

https://www.jbc.org/article/S0021-9258(20)55117-X/fulltext

Naturally occurring organic osmolytes: From cell physiology to disease prevention

https://iubmb.onlinelibrary.wiley.com/doi/10.1002/iub.406

Osmolytes: Wonder molecules to combat protein misfolding against stress conditions

https://www.sciencedirect.com/science/article/abs/pii/S014181302300555X

Osmolytes: A Possible Therapeutic Molecule for Ameliorating the Neurodegeneration Caused by Protein Misfolding and Aggregation

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7022651/

Polyol and sugar osmolytes can shorten protein hydrogen bonds to modulate function

https://www.nature.com/articles/s42003-020-01260-1

Role of Osmolytes in Amyloidosis

https://www.intechopen.com/chapters/65859

Sugar osmolyte inhibits and attenuates the fibrillogenesis in RNase A: An in vitro and in silico characterizations

https://www.sciencedirect.com/science/article/abs/pii/S0141813023042757?via%3Dihub

Basic concepts and practical equations on osmolality: Biochemical approach

https://www.sciencedirect.com/science/article/abs/pii/S0009912016300972

Combinations of Osmolytes, Including Monosaccharides, Disaccharides, and Sugar Alcohols Act in Concert During Cryopreservation to Improve Mesenchymal Stromal Cell Survival

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5125256/

..

Osmolyte
Inorganic Ions
Methylamines
Hypertonicity
Hyperosmolality
Protein Backbone
Renal Medulla
Renal Medullary Cells
Aldose Reductase

Ionic Strength
Macromolecular Crowding

Protective Osmolytes
Denaturing Osmolytes

Although many biochemical functions require specific inorganic ions, increasing the concentrations of these ions above those typically found in cells perturbs protein function. In contrast, organic osmolytes have much less effect, i.e. are compatible. Hypertonicity, as results from high NaCl, causes osmotic flux of water out of cells, elevating the concentration of all cellular constituents, including inorganic salts.

High concentrations of protective organic osmolytes stabilize protein structure. The mechanism of stabilization involves strong exclusion of the protective osmolytes from the surface of proteins. On the other hand, denaturing osmolytes accumulate at the surface of proteins. Protective osmolytes push the equilibrium of protein folding toward the native form, whereas denaturing osmolytes push it toward the unfolded form.

What is the sensor of hypertonicity that activates protective osmoregulatory responses in mammalian cells? Hypertonicity causes a rapid decrease in cell volume, an increase in concentration of all intracellular components (including inorganic ions and macromolecules), and reorganization of the cytoskeleton.

Macromolecular crowding and ionic strength, in particular, have profound effects on biochemical processes, which could contribute to the increased ROS, DNA breaks, and altered activity of kinases and other enzymes that are involved in activating TonEBP/OREBP.

..

https://en.m.wikipedia.org/wiki/Osmolyte

https://en.m.wikipedia.org/wiki/Inorganic_ions

https://en.m.wikipedia.org/wiki/Ionic_strength

https://en.m.wikipedia.org/wiki/Macromolecular_crowding

..

Renal medullary osmolytes NaCl and urea differentially modulate human tubular cell cytokine expression and monocyte recruitment

https://onlinelibrary.wiley.com/doi/full/10.1002/eji.202149723

..

Kidney
Medulla
Renal
N-Acetylcysteine (NAC)

Vinegar
Nitrogen
Sulfur
Minerals
Creatinine

..

Ole Molly Tea
Osmolyte
O Smolyte
O Smo Lyte
O Small LIte
Old Small Light

Osmolyte
Lipotropic
Methyl Doner
Protecting Group

Osmolytes represent different chemical classes that occur naturally such as

amino acids:
proline
glycine

methylamines :
betaine
trimethylamine-N-oxide

sugar alcohols (polyol):
sucrose
mannitol
sorbitol
pinitol

tertiary sulfonium: dimethylsulfoniopropionate
(DMSP)

quaternary ammonium compounds:
glycine betaine
proline betaine
(stachydrine)
β-alanine betaine
pipecolate betaine
(homostachydrine)
hydroxypipecolate betaine
choline-O-sulfate
trigonelline
(nicotinic acid betaine)

..

this is mostly just sugars broken down into there smallest molecules, nearly amino acids.

so by adding more & more sugars into vinegar manufactures amino acids & osmolytes.

thats my original idea, dumping lots of raw honey into vinegar until it becomes super saturated & complex!

"Osmolyte"
"Telomere"

Tau
Tautomer
Telomere
Telomerase

The principle mechanism by which telomeres are maintained is through the actions of an enzyme termed telomerase.

One of the more potent and selective inhibitors of telomerase to have been identified is telomestatin, a natural product isolated from Streptomyces anulatus. Telomestatin is a macrocyclic torand consisting of seven oxazole rings and one thiazoline ring.

..

Hydrogen bonds between sugar and nearby molecules help to determine the level of sweetness.

..

Glycerate
Glyceric Acid

https://www.sciencedirect.com/topics/medicine-and-dentistry/glyceric-acid

..

Trigonelline (Nitrogen)

Dimethylsulfoniopropionate (DMSP / Sulfur)

..

Glucosylglycerate
Glycerate
Glyceric Acid
Glycerate Dehydrogenase

Strategies for the synthesis of the osmolyte glucosylglycerate and its precursor glycerate

https://link.springer.com/article/10.1007/s00253-024-13139-w

One-pot sustainable synthesis of glucosylglycerate from starch and glycerol through artificial in vitro enzymatic cascade

https://www.sciencedirect.com/science/article/abs/pii/S0960852424003146?via%3Dihub

Glucosylglycerate (R-2-O-α-D-glucopyranosyl-glycerate, GG), a structural analog of MG, can be found in enterobacteria, marine cyanobacteria, and halophilic methanogens under nitrogen-limited or salt stress.

..

Osmolyte
Glucose
Glycerol
Acetate

Quantitative Analysis of Glycerol Accumulation, Glycolysis and Growth under Hyper Osmotic Stress

https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1003084

Effect of Fermentation Temperature and Culture Medium on Glycerol and Ethanol during Wine Fermentation

https://www.ajevonline.org/content/63/1/132

The accumulation of glycerol, glycerol-3-phosphate dehydrogenase (GPD) activity, and the level of expression of the GPD1 gene were highest in the initial stages of fermentation, which potentially counteracted the hyperosmotic stress caused by the high concentration of sugar in the media. More glycerol was produced during fermentation at 25°C than at 13°C.

..

High Osmolarity Glycerol (HOG)

The yeast osmostress response is carbon source dependent

https://www.nature.com/articles/s41598-017-01141-4

The High Osmolarity Glycerol (HOG) Pathway Functions in Osmosensing, Trap Morphogenesis and Conidiation of the Nematode-Trapping Fungus

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7711997/

Do Osmolytes Impact the Structure and Dynamics of Myoglobin?

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321238/

small osmolytes like taurine and glycine betaine do not strongly change the protein solvation environment, but polyols like trehalose and sorbitol having multiple H-bonding sites are found to be protein-protectants.

Creatine as a compatible osmolyte in muscle cells exposed to hypertonic stress

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1890352/

Effect of osmolytes on in-vitro aggregation properties of peptides derived from TGFBIp

https://www.nature.com/articles/s41598-020-60944-0

Trimethylamine N-oxide stabilizes proteins via a distinct mechanism compared with betaine and glycine

https://www.pnas.org/doi/full/10.1073/pnas.1614609114

Implications of trimethylamine N-oxide (TMAO) and Betaine in Human Health: Beyond Being Osmoprotective Compounds

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9601739/

Effect of Natural Osmolytes on Recombinant Tau Monomer: Propensity of Oligomerization and Aggregation

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10995947/

Brain Metabolite, N-Acetylaspartate Is a Potent Protein Aggregation Inhibitor

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7894078/

Acetyl-CoA and the Regulation of Metabolism: Mechanisms and Consequences

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4380630/

Mechanism of Osmolyte Stabilization–Destabilization of Proteins: Experimental Evidence

https://pubs.acs.org/doi/10.1021/acs.jpcb.2c00281

Sweet and sour synergy: exploring the antibacterial and antibiofilm activity of acetic acid and vinegar combined with medical-grade honeys

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10433418/

Characterizing osmolyte chemical class hierarchies and functional group requirements for thermal stabilization of proteins

https://www.sciencedirect.com/science/article/pii/S0301462220301186

Potassium Glutamate and Glycine Betaine Induce Self-Assembly of the PCNA and β-Sliding Clamps

https://www.sciencedirect.com/science/article/pii/S0006349520309012

TMAO: Protecting proteins from feeling the heat

https://www.cell.com/biophysj/fulltext/S0006-3495(23)00161-3

Vault (Organelle)

https://en.m.wikipedia.org/wiki/Vault_(organelle)

vaults (especially the MVP) were over-expressed in cancer patients who were diagnosed with multidrug resistance.

..

Macromolecule

Macromolecular Crystal Structures

Phospholipid-induced prion conversion

Macromolecules co-purified with PrPSc from brain tissues were suspected to be involved in PrP conversion. One of the main findings was that polyanionic compounds, such as RNA and proteoglycans, interact and convert endogenous and bacterially expressed PrPC.

..

Glycosyl
Glycosylation
Glycoprotein
DNA Glycation
Advanced Glycation End-products (AGEs)
Methylglyoxal
Glyoxal
Proteoglycan
Polyanion
Polyanionic Electrolyte
Glycosylphosphatidylinositol (GPI)
..

Glycosylation is the process by which a carbohydrate is attached to a target macromolecule, typically proteins and lipids.

prion protein sensitizes neurons to glutamate-induced excitotoxicity.

interaction between metabotropic.glutamate receptor 5 and cellular prion protein.

Among the viral proteins is HIV-1 envelope Glycoprotein 120

..

Neurometals in the Pathogenesis of Prion Diseases

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7866166/

..

this article may be a bit misleading, by saying Prion "uses" Zinc & Copper for spreading.

because brass is toxic to prion, what its likely doing is breaking the neurological metal connections down into deposits.

testing minerals, vinegar & niacin, it never occurred to me that Methyl Doner as Osmolyte & Inorganic Ions work together for homeostasis, acting like Brass & Methylene Blue.

..

Glucose
Glutamate
Melanin

..

Glucose metabolism regulates expression of hair-inductive genes of dermal papilla spheres via histone acetylation

https://www.nature.com/articles/s41598-020-61824-3

..

TMG
Trimethylglycine
Betaine Anhydrous
Glycerol+Nitrogen

IHN
Inositol Hexanicotinate
Nicotinate Inositol
Nitrogen+Glycerol

for a Sulfur element Thiamine B1, NAC, or just MSM.

but most important is the Inorganic Salts Ions with Nitrogen & Glycerol.

plus Acetate seems important as well, to charge the Ions.

NAC (N-acetylcysteine)

Acetyl = Acetate = Acetic
Acetyl-CoA = Vinegar

testing both, the supplements together & the raw material, vinegar, vegetable glycerin, minerals complex, nitrogen source.

its ultimately doing rhe same thing, the supplements are overlapping elements.

its ultimately looking like Creatinine.

problem with Creatinine is its found is excess with Kidney Disease,

Nephrotic Syndrome
Nephritic Syndrome

the problem is not from the Creatinine, but Retinol disfunction that locks all other Kidney Enzyme functions called Hypervitaminosis A.

what Creatinine seems to be missing is the Glycerol & Salt Ions, and possibly the Acetate Acetyl.

its a complex supplement, so it difficult to tell what its missing.

but ultimately the goal is to fix the Retinol pathways, before anything else begins to improve.

if i had to make a guess what fixes Retinol lock, its the Vinegar, Minerals & Glycerol.

this combinations is so powerful, it absorbs threw the skin instantly, identical to DMSO.

Nitrogen element is more important for different things down the enzyme pathways.

may have discovered a way to manufacture something close enough to Vegetable Glycerin, without having to do it via Soap Making using Oil & Lye.

vinegar with live yeast (mother), just slowly keep adding sugarnor honey, as it continues to ferment, eventually it will become oversaturated, and that covers both Vinegar (Acetyl) & Sugar Alcohol (Polyol).

its close enough to Glycerol to do the thing, just needs a tablespoon of Minerals.

regarding Hypervitaminosis A, dont think is because Vitamin A is toxic, but pesticides & parasites manufacturing identical chemical compounds as pesticides.

all chronic disease seems to be dependent upon this as the first cog in metabolism & homeostasis.

the biggest clues right now..

regarding the Nitrogen element in both TMG & IHN, is that they dont actually cure any disease.

but they do have something in common, called Methyl Doner, a Glycerol that is also a Osmolyte.

this is the biggest clue into how Hydrogen is the secret element.

Nitrogen is helpful regarding NAD/NADH mitochondria metabolism.

to loosen a Prion bond, is the goal here.

Inorganic Salts & Osmolyte work together almost as a single unit, and both are charged via Acetate (Vinegar).

..

Betaine (Trimethylglycine), in my opinion, combined with Vinegar & Minerals, its the backbone for all the B Vitamins, Amino Acids, Lipids, Creatinine, SAMe, Glutathione ect..

and its the smallest & likely most effective Osmolyte compound, known to refold misfolded proteins, or Prion Amyloidosis.

Homocysteine MTHFR disfunction is kind likebthe very first step in toxic enzyme locks, it fixes that to.

so im assuming it repair Retinol pathways as well.

its so small it puts Hydrogen into the toxic acids, breaks everything up at the core, just like the plan all along, Enzyme Activator, Osmolyte, Methyl Doner ect..

im trying to pump the vinegar fermentation with raw honey, oversaturate the sugars to see if it becomes like a Glycerol, and then would only require a Nitrogen & Minerals.

but thats down the road, not sure if that will actually work.

..

N-Glycoprotein
Nitrogen (Osmolyte)

S-Glycoprotein
Sulfur (Spike)

Heparan Sulfate
N-Deacetylation
N-Sulfation

N-Acetylglucosamine
(GlcNAc)

Carrageenan (Red Algae)
Sulfated Polysaccharide
Galactopyranose
Anionic Polysaccharide

..

its likely this is whis why Nitrogen is helpful with Polyol, to keep it from becoming sulfated.

may have figured why Nitrogen is so important, because it the only element to break apart a Sulphur bond.

..

Cellular internalization of alpha-synuclein aggregates by cell surface heparan sulfate depends on aggregate conformation and cell type

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5566500/

Heparan sulfate has been found in all extracellular amyloid deposits investigated, regardless of the nature of the amyloid protein.

The sulfation code for propagation of neurodegeneration

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6036190/

It was reported for α-synuclein that internalization of amyloid fibrils depends on heparin sulfate, whereas that of smaller non-amyloid oligomers does not. Thus, binding of smaller oligomeric forms of tau and other protein aggregates to HSPGs should be investigated.

..

Methylation
DNA Methyltransferase
Acetylation
Histone Acetyltransferase
Methyl
Acetate Ion
Enzyme
Chromatin
Osmolyte

The Key Role of DNA Methylation and Histone Acetylation in Epigenetics of Atherosclerosis

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7521974/

..

The Genetic Systems of Mitochondria and Plastids

https://www.ncbi.nlm.nih.gov/books/NBK26924/

..

Fenbendazole
Benzimidazole
Oxfendazole
Imidazole
Alkaloid
Tubulin Inhibitor
Mitotic Inhibitor
Benzimidazolide
Methoxycarbonyl
Phenylsulfanediyl

https://en.m.wikipedia.org/wiki/Imidazole

https://en.m.wikipedia.org/wiki/Benzimidazole

https://en.m.wikipedia.org/wiki/Oxfendazole

https://en.m.wikipedia.org/wiki/Mitotic_inhibitor

Fenbendazole
Benzimidazole

Fenbendazole is a member of the class of benzimidazoles.

Most prominent benzimidazole complex features N-ribosyl-dimethylbenzimidazole, as found in vitamin B12.

Benzimidazole and its derivatives as cancer therapeutics: The potential role from traditional to precision medicine

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9978992/

Benzimidazole contains a hydrogen atom attached to nitrogen in the 1-position and can form a tautomer upon interaction with aprotic solvents, such as water.

..

Tautomers are structural isomers of chemical compounds that readily interconvert. The chemical reaction interconverting the two is called tautomerization. This conversion commonly results from the relocation of a hydrogen atom within the compound.

Ammeline
Annular Tautomerism

Role of tautomerism in RNA biochemistry

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4274630/

On Tautomerism and Amphoterism: An In-Depth Structural and Physicochemical Characterization of Ammeline and Some of Its Salts

https://onlinelibrary.wiley.com/doi/10.1002/anie.202404927

..

Betaine Osmolyte Methyl Doner (Prion) & Fenbendazole Annular Tautomer Mitotic Inhibitor (Cancer).. both very specifically have to do with Hydrogen Bonds.

by adding honey to vinegar fermentation, does appear to be making a natural form of Glycerol, so that is promising.

but wonder about Betaine with drops of DMSO, to replicate a Fenbendazole like derivative, deactivate both Prion & Cancer?

mixed equil parts Betaine & MSM with water in an eye dropper, they dont mix together in water, sinks to the bottom, but the taste of it is exactly the strange chalky flavor of Fenbendazole.

MSM is very bitter, Betaine is very sweet, together tastes like chalk or almost like wood glue, its hard to explain.

it turns slick like silicone on the skin, but not oily.

..

DMSO and betaine greatly improve amplification of GC-rich constructs in de novo synthesis

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2883997/

Though we found no benefit in employing either DMSO or betaine during the assembly steps, both additives greatly improved target product specificity and yield during PCR amplification.

..

TMG (Betaine)
DMSP (DMSO)

i think the Betaine is turning the DMSO/MSM into the Osmolyte DMSP.

3 parts Nitrogen, to 1 part Sulfur, for Fenbendazole derivative.

and the Acetate Ions with oversaturated Honey Glycerol help to bind up parasites & cancer microtubules.

Betaine seems to neutralize the side effects of both Acetate Ions & DMSO Sulfur.

Acetyl is a Osmolyte very specific to brain homeostasis, found a bunch of articles.

Acetyl (Vinegar)
Acetyl-CoA
N-acetylaspartate (NAA)

beginning to get the idea that, if all the Osmolytes are combined together, then..

what do all Osmolytes have in common?

the most reduced non-toxic molecular state of Hydrogen, Oxygen, Carbon, Nitrogen & Sulfur.

see how difficult it was to just find out this simple observation, my previous months ago vinegar trial was just put everything in it & see what happens, now i know exactly what to refine the ingredients.

Vinegar
Betaine
MSM (not much)
Minerals

one important the reason for the minerals is because Osmolyte elements are identical to Chelation compounds, and would likely Chelate electrolytes out.

honey added seems very similar to Glucagon.

quickly looking at Glucagon, it has an odd reaction, temporary slows digestion?

this tells me that its almost like proto-amino acids, or almost like stem cell food, the body can instantly make anything it wants with it.

one thing vinegar, niacin derivative & sulfur, it dont take very long to know you took it, lightning fast.

my final test is to convert regular hit niacin into non-flush, vinegar along only enhances the flush, bit together with honey as a carbon buffer may act as a glycerol.

reason i think honey & vinegar can be used as a glycerol substitute, both honey & glycerol are sweet, vinegar is the byproduct of alcohol production, and glycerol is a sugar alcohol called polyol.

if this is correct, then it should buffer niacin flush, because the simple sugar one-carbon metabolic CH3 methyl doner.

problem with pure vegetable glycerol is that it wont actually mix or bind with anything else.

honey & vinegar together at first is a little sticky, over time it becomes almost oily like silicone.

for over 2 years i was testing vinegar minerals, with a concern Acetate Ions may be toxic Anion or Cation, just recently found enough evidence it is not toxic, but causes crystal like formations in the skin, making it dry & irritated nothing seemed to quite break it up, except the Betaine instantly started helping, so the honey vinegar idea came about, because combined with the nitrogen & a little sulfur, it chelated the nano salt crystals.

Acetate
Hot-Ice (Crystals)

..

Acetate
Hot-Ice (Crystals)

https://pediaa.com/what-is-the-difference-between-sodium-acetate-and-sodium-acetate-trihydrate/

https://sciencenotes.org/make-hot-ice-from-baking-soda-and-vinegar/

Glucagon

https://en.m.wikipedia.org/wiki/Glucagon

Glucagon’s Metabolic Action in Health and Disease

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8513137/

..

CHARM

Coupled Histone tail for Autoinhibition Release Methyltransferase

https://en.m.wikipedia.org/wiki/Histone_methyltransferase

https://en.m.wikipedia.org/wiki/Betaine—homocysteine_S-methyltransferase

..

Astaxanthin

https://en.m.wikipedia.org/wiki/Astaxanthin

i believe viruses are manufactured by mitochondria endosymbiont DNA parasites, that hyjack exosome into spores via corallicolid plastid & mycoplasma via carboxysome microcompartments & organelle vaults.

definition of virus as "not-alive", some symbionts go dormant for 20 years, hidden in bone marrow, until just the right conditions, mimicking age related diseases, immortal cell lines, passed on to children as genetic disorders.

this is why viruses are generally uncureable, because as mitochondria environment becomes uninhabitable via meditations, they just go dormant until suitable conditions.

until all this gets sorted out correctly, viruses will remain uncureable.

may need very specific osmolyte ion cocktails, specific to feed mitochondria & flush out DNA parasites.

..

Mechanism of Osmolyte Stabilization–Destabilization of Proteins: Experimental Evidence

is Osmolyte Stabilization a Prion?

fell asleep reading about this & dreaming of it, and the conclusion this morning was this.

misfolded Glycoprotein has to do with Osmolyte Stabilization.

meaning its two separate lines of research, talking about the same thing.

havent determined if Stabilization or Destabilization of Osmolyte is good or bad, folding or misfolding prion.

how can Osmolytes specifically unfold prion back to original protein state, unless directly related?

red algae make osmolytes Formate Dehydrogenase FDH, Floridoside & Trehalose for protection, corral reef have a mysterious malaria algae symbiont called corallicolid.

scientists using exotic osmolytes to manufacture synthetic microtubule molecular machines from prion?

Algae symbiont manufacture exotic extremophile osmolyte transform mitochondria homeostasis.

..

testing the Betaine, the Nitrogen is still too hot, making mega dosing nor practical for medical applications, just small amounts for Methyl Doner issues.

i need the Osmolyte properties, without the Nitrogen, and specially with Oxygen.

what is this have in common?

O-Linked Glycosylation
O-Glycan
O-Smolyte

..

O-Glycan for Homeostasis

Cortisone
Cortisol
Steroid
Corticosteroid

..

Carboxylic Acid (COOH)
Methylene Group (CH2)

trying to pinpoint, is osmolyte a more a functional group, or an amino acid?

it seems to kind of be similar to how fermentation can be "with or without oxygen" depends upon the outcome, same kind of thing.

reason i need the exact definition or chemical compound of vinegar & honey together is because its difficult to find this connection clearly.

"Osmolyte" "Oxymel"

its really difficult to prove its true, that Oxymel is a very simple Osmolyte.

the reason i think its so important is because, if its true, then it may use excess or even toxic forms of Nitrogen & Sulfur, converting it into a form of Fenbendazole naturally.

meaning it will convery Glucose into Glycan, not only as a neuroprotective, but a safe microtubule binding compound, against cancer, candida, parasites and even unfolding misfolded proteins.

here is why the idea came about ..

noticed slight ear ringing with high dose, first with high dose B1 Thiamine, B3 Non-Flush Niacin, then Betaine TMG.

when talking vinegar with B vitamins, noticed a little bump in the ringing for about an hour.

when taking Oxymel alone, ears start ringing & body buzzing for much longer, from B vitamins days previous.

its directly interacting with latent Nitrogen & Sulfur.

seems like ..

1/4 honey to
3/4 vinegar.

equil amount 50/50 may be a little sweet & not enough kick.

..

Neutralize excess Nitrogen by adding more honey to vinegar, carbohydrate metabolism requires a Nitrogen, similar to Neutralize Niacin flush requires Inositol (Glycan).

Vinegar Fermentation
Oxygen Doner

Aerobic fermentation or aerobic glycolysis is a metabolic process by which cells metabolize sugars via fermentation in the presence of oxygen.

Vinegar has the extra Oxygen to charge Glucose sugars into Glycan Osmolyte?

Prion

Glycosyl
"phosphate"
idyl
inositol

O-(Oxygen)
Acyl-Acetate (Vinegar)

knocks out the Phosphate in misfolded prion protein?

Prion is formed from mitochondria by a malfunctioning Phosphate Dehydrogenase process, also required to make ATP?

Ole Molly Tea
Osmolyte
O Smolyte
O Smo Lyte
O Small LIte
Old Small Light

..

Deep-sea osmolyte finds applications in molecular machines

https://www.asiaresearchnews.com/content/deep-sea-osmolyte-finds-applications-molecular-machines-0

Sequence-based identification of inositol monophosphatase-like histidinol-phosphate phosphatases (HisN) in Corynebacterium glutamicum, Actinobacteria, and beyond

https://bmcmicrobiol.biomedcentral.com/articles/10.1186/s12866-017-1069-4

..

Histidinol-Phosphate Phosphatase (HolPase)

Inositol Monophosphatase (IMPase)

Glycosylphosphatidylinositol

The eighth step of L-histidine biosynthesis is carried out by an enzyme called histidinol-phosphate phosphatase (HolPase). Three unrelated HolPase families are known so far. Two of them are well studied: HAD-type HolPases known from Gammaproteobacteria like Escherichia coli or Salmonella enterica and PHP-type HolPases known from yeast and Firmicutes like Bacillus subtilis.

However, the third family of HolPases, the inositol monophosphatase (IMPase)-like HolPases, present in Actinobacteria like Corynebacterium glutamicum (HisN) and plants, are poorly characterized. Moreover, there exist several IMPase-like proteins in bacteria (e.g. CysQ, ImpA, and SuhB) which are very similar to HisN but most likely do not participate in L-histidine biosynthesis.

..

(TMA)
Trimethylamine

(TMAO)
Trimethylamine N-Oxide

(TMAU)
Trimethylaminuria

(TOR)
Trimethylamine N-Oxide Reductase

(CYT-C)
Cytochrome Complex

(FMO3)
Flavin Monooxygenase 3

..

Implication of Trimethylamine N-Oxide (TMAO) in Disease: Potential Biomarker or New Therapeutic Target

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6213249/

Methionine Metabolism: Key Enzymes, Reactions, and Interplay with Cellular Pathways

https://www.creative-proteomics.com/blog/index.php/understanding-methionine-metabolism/

Sink into the Epigenome: Histones as repositories that influence cellular metabolism

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6109460/

Glycoside vs. Aglycon: The Role of Glycosidic Residue in Biological Activity

https://link.springer.com/referenceworkentry/10.1007/978-3-540-30429-6_67

Unforeseen crystal forms of the natural osmolyte floridoside

https://www.nature.com/articles/s42004-020-00376-z

Glycation Damage: A Possible Hub for Major Pathophysiological Disorders and Aging

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6147582/

Current Methods for the Characterization of O-Glycans

https://pubs.acs.org/doi/10.1021/acs.jproteome.0c00435

Iminosugars: A host-targeted approach to combat Flaviviridae infections

https://www.sciencedirect.com/science/article/pii/S0166354220302953

..

Methionine synthase transfers a methyl group from 5-methyl-tetra-hydro-folate to homocysteine, yielding methionine and tetra-hydro-folate.

Choline, a trimethylamine-containing compound and part of the head group of phosphatidylcholine, is metabolized by gut microbiota to produce an intermediate compound known as trimethylamine (TMA). TMA is rapidly further oxidized by hepatic flavin mono-oxygenases to form trimethylamine N-oxide (TMAO).

..

Methyl Doner
Osmolyte

Glucagon

CHARM
Coupled Histone Autoinhibition Release Methyltransferase

[Sulfur Toxicity]
Hyperhomocysteinemia
Methyl-Hydrogen-Folate
MTHFR
Methionine
Homocysteine
Cysteine
Choline
Betaine
Methylamine
Trimethylamine
Trimethylaminuria
[Nitrogen Toxicity]

Cysteine & Choline the point between two oppsite spectrum of gene disorders, enzyme one-carbon metabolism malfunction.

Trimethylaminuria is a rare problem, in comparison to MTHFR Hyperhomocysteinemia.

in the center balanced is some kind of Osmolyte molecule, universal enzyme, stem cell tonic, telomere booster.

..

DNA Methyltransferase
Homocysteine (HCY)
S-Adenosyl Homocysteine (SAH)

(SAH)
Bisulfide
Sulfane
Sulfanyl
Butyrate
Butter

Vinegar
Hydrogen Acetate
Methane Carboxylate
Ethylic Acid
Ethanoic Acid

Honey
Monosaccharides
Fructose
Glucose

Enzyme Hydrolysis
Glycogenolysis
Glycoprotein
Glucagon
Glycation
Glycosyl
Glycerol
Glycoside
Glycosidase
Aglycone
Osmolyte

Glycosides can be activated by enzyme hydrolysis, which causes the sugar part to be broken off, making the chemical available for use.

Aglycone-fed mice displayed strong autophagic reactions, mTOR regulation, and reduced plaque deposits and ß-amyloid levels.

..

Formate Dehydrogenase FDH
Floridoside
Trehalose

..

[Sulfur Toxicity]
Hyperhomocysteinemia

[Nitrogen Toxicity]
Trimethylaminuria

both extrems of Osmolyte malfunction, yet Sulfur being Spike (Prion).

S-Glycoprotein
Spike (Prion) = Sulfur

Heparan Sulfate

to undo this prion binding..

Osmolyte
Oxymel
Glycoside
Glycone
Aglycone

Glycosidic Bond:

O- Oxygen
S- Sulfur
N- Nitrogen
C- Carbon

Glucuronic Acid
Glucuronidation
Glycoside Hydrolases
Glycosynthases
Glucuronidases
Glucuronoside
Glucuronide

Extracellular Polymeric Substance (EPS)

..

O-Linked Glycosylation
O-Glycan
O-GalNAc

Osmolyte
O-Smolyte
O-Smalyte

O-(Oxygen) Glycan
Hydroxyl Group
Serine
Hreonine
Tyrosine

..

Glycans are attached to proteins in four different ways

N-linked to asparagine (Asn),

O-linked to the hydroxyl groups of serine (Ser), threonine (Thr) or tyrosine (Tyr),

C-linked to tryptophan
S-linked ..

..

Functional Group

O-Glycan
Osmolyte
Oxymel

Carboxylic Acid (COOH)
Methylene Group (CH2)

Oxygen Glycan
Acetylation

O-Glycan
O-Linked Glycosylation
O-GlcNAcylation
O-GlcNAc

O-GlcNAc Transferase
O-GlcNAcase

..

Sugar Acid

Aldonic Acid
Aldaric Acid
Ulosonic Acid
Uronic Acid
Glyceric Acid
Gluconic Acid

Acidic Acid Sugar
Protecting Groups -OH
Monosaccharide
Carboxyl
Glycoside
Glycosyl

..

Prion
Glycoprotein
Glycosylphosphatidylinositol
C-terminus
Myelination
Myelin

Proteases Enzymes
Aldosterone

Inositol-Phosphate Phosphatase

https://en.m.wikipedia.org/wiki/Inositol-phosphate_phosphatase

Phosphoglycerate kinase: structural aspects and functions, with special emphasis on the enzyme from Kinetoplastea

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7729029/

Copper-catalyzed oxidation of the recombinant SHa(29–231) prion protein

https://www.pnas.org/doi/10.1073/pnas.121190898

Both N-Terminal and C-Terminal Histidine Residues of the Prion Protein Are Essential for Copper Coordination and Neuroprotective Self-Regulation

https://www.sciencedirect.com/science/article/abs/pii/S0022283620303697

..

The eighth step of L-histidine biosynthesis is carried out by an enzyme called histidinol-phosphate phosphatase (HolPase). Three unrelated HolPase families are known so far.

Two of them are well studied: HAD-type HolPases known from Gammaproteobacteria like Escherichia coli or Salmonella enterica and PHP-type HolPases known from yeast and Firmicutes like Bacillus subtilis.

However, the third family of HolPases, the inositol monophosphatase (IMPase)-like HolPases, present in Actinobacteria like Corynebacterium glutamicum (HisN) and plants, are poorly characterized.

Moreover, there exist several IMPase-like proteins in bacteria (e.g. CysQ, ImpA, and SuhB) which are very similar to HisN but most likely do not participate in L-histidine biosynthesis.

..

https://en.m.wikipedia.org/wiki/Glucuronidation

Various glycoside hydrolases have shown efficacy in degrading matrix polysaccharides within the extracellular polymeric substance (EPS) of microbial biofilms. Medically, biofilms afford infectious microorganisms a variety of advantages over their planktonic, fre-floating counterparts, including greatly increased tolerances to antimicrobial agents and the host immune system. Thus, degrading the biofilm may increase antibiotic efficacy, and potentiate host immune function and healing ability. A combination of alpha-amylase and cellulase was shown to degrade polymicrobial bacterial biofilms from both in vitro and in vivo sources, and increase antibiotic effectiveness against them.

..

Heparan Sulfate
Copper

A new convergent chemoenzymatic synthesis strategy, integrating enzymatic synthesis of heparan sulfate, sortase A ligation, copper(i)-catalyzed alkyne-azide cycloaddition, and solid phase peptide synthesis, has been established to efficiently synthesize a mimetic of heparan sulfate proteoglycan syndecan-1 glyco-polypeptide at a milligram scale.

heparan sulfate mimetics having a domain structure were synthesized by copper catalyzed alkyne-azide cycloaddition of HS oligosaccharide having a terminal alkyne or azide moiety.

Heparan sulfate penetrates the membrane and is transported to the nucleus. This process is dependent on copper and on expression and processing of the amyloid precursor protein.

..

O-GlcNAc
O-GlcNAcylation

In Alzheimer’s disease, a cytosolic phosphoprotein called Tau, is abnormally phosphorylated. The reason for this was attributed to an overall decrease in O-GlcNAcylation, a novel type of O-glycosylation by which the monosaccharide β-N-acetylglucosamine (GlcNAc) attaches to serine /threonine residues via an O-linked glycosidic bond.

..

Asparagine Peptide Lyase
Intein-Containing Proteins

An intein is a protein contained within another protein, the extein. Parasitic DNA infects an intein gene, which encodes an endonuclease. The resulting cDNA (complementary DNA) encodes the extein along with the intein. The intein contains a self-cleaving domain, which has the endonuclease nested within it. The intein domain performs two proteolytic cleavages at its own N-terminus and C-terminus and releases from the extein, separating it in two fragments.

..

Protein Splicing

https://en.m.wikipedia.org/wiki/Protein_splicing

..

The microtubule-associated protein tau is abnormally hyperphosphorylated when isolated from the brain of patients who suffer from Alzheimer's disease. This is due to the dysfunction of dephosphorylation mechanisms at specific amino acids on the tau protein. Tau dephosphorylation is catalysed by protein phosphatase-2A and phosphatase-2B.

https://en.m.wikipedia.org/wiki/Dephosphorylation

Phosphatase
Phosphorylase Kinase
Glycogen Phosphorylase
Phosphoglycerate Kinase
Hexokinase

https://en.m.wikipedia.org/wiki/Phosphatase

https://en.m.wikipedia.org/wiki/Phosphorylase

..

Lipid-protein interactions modulate the conformational equilibrium of a potassium channel

https://www.nature.com/articles/s41467-020-15741-8

..

1H, 15N, 13C backbone resonance assignments of human phosphoglycerate kinase in a transition state analogue complex with ADP, 3-phosphoglycerate and magnesium trifluoride

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5594045/

Phosphoglycerate kinase is a bisubstrate magnesium-dependent enzyme with highly conserved amino acid sequences found in all living organisms.

Magnetic isotope effect of magnesium in phosphoglycerate kinase phosphorylation

https://www.pnas.org/doi/10.1073/pnas.0504876102

Phosphoglycerate kinase (PGK) is found to be controlled by a 25Mg2+-related magnetic isotope effect. Mg2+ nuclear spin selectivity manifests itself in PGK-directed ADP phosphorylation, which has been clearly proven by comparison of ATP synthesis rates estimated in reaction mixtures with different Mg isotopy parameters.

..

Myelin
Ranvier
TREK
TRAAK
Lipid
Potassium

Mechanosensitivity is mediated directly by the lipid membrane in TRAAK and TREK1 K+ channels

https://www.pnas.org/doi/10.1073/pnas.1320768111

Osmolyte
Glycosylation
Prion
Potassium
G-Quadruplexes

https://en.m.wikipedia.org/wiki/G-quadruplex

Redox mechanisms and their pathological role in prion diseases: The road to ruin

https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1011309

In the unglycosylated mutants, PrPC was localized on the cell surface and readily converted to PrPSc, indicating that glycans are not necessary for prion infection but rather a lack of glycation favours misfolding and PrPSc transmission.

Potassium Channels, Glucose Metabolism and Glycosylation in Cancer Cells

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10178682/

Ion channels are one of the key proteins responsible for tumor cell survival and metastasis. It turns out that the altered expression of ion channels can be considered as one of the hallmarks of cancer, and several ion channel types have been linked to cancer cell chemoresistance.

Glycosylation Increases Potassium Channel Stability and Surface Expression in Mammalian Cells

https://www.jbc.org/article/S0021-9258(19)34809-4/fulltext

Importance of Glycosylation on Function of a Potassium Channel in Neuroblastoma Cells

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3082577/

..

G-Quadruplexes
FMRP (Protein)
Arginine-Glycine

FMR1
Fragile X Messenger Ribonucleoprotein 1
Human Gene
Fragile X Messenger Ribonucleoprotein

https://en.m.wikipedia.org/wiki/FMR1

https://en.m.wikipedia.org/wiki/Chromatin

..

making homemade Osmolytes using vinegar & honey, for some reason Potassium is making it work better.

previously tested all other minerals with Osmolyte, only Potassium seems to kickstart reactions.

Avocado (136 grams) contains 690 mg of potassium

..

Sugar Acid
Carboxyl
Aldose
Triose
Glycan
Glycerol
Glycinate
Methyl Donor
CH3
COOH
Potassium
Ion Charge

Glyceraldehyde (glyceral) is a triose monosaccharide with chemical formula C3H6O3. It is the simplest of all common aldoses.

Glyceraldehyde can be prepared, along with dihydroxyacetone, by the mild oxidation of glycerol, for example with hydrogen peroxide and a ferrous salt as catalyst.

https://en.m.wikipedia.org/wiki/Glyceraldehyde

..

NADPH Oxidases, Reactive Oxygen Species, and the KidneyFriend and Foe

https://journals.lww.com/jasn/Fulltext/2013/10000/NADPH_Oxidases,_Reactive_Oxygen_Species,_and_the.6.aspx

Mitochondrial potassium channels and reactive oxygen species

https://www.sciencedirect.com/science/article/pii/S0014579310000323

Toxic
Acetyl Quinoline Inhibitor
Oxidized Phosphate

Cholinesterase

Acetylcholinesterase Inhibitor

https://en.m.wikipedia.org/wiki/Cholinesterase

https://en.m.wikipedia.org/wiki/Acetylcholinesterase_inhibitor

https://en.m.wikipedia.org/wiki/Glycosylphosphatidylinositol

https://en.m.wikipedia.org/wiki/Phospholipase

https://en.m.wikipedia.org/wiki/Phosphodiesterase

https://en.m.wikipedia.org/wiki/Phosphodiesterase_inhibitor

https://en.m.wikipedia.org/wiki/Phosphodiester_bond

..

Cholinesterase
Phospholipase
Phosphodiesterase
Phosphodiester Bond
Phosphodiesterase Inhibitor
Acetylcholinesterase Inhibitor

[Prion]
Glycosylphosphatidylinositol

Glycosyl Phosphatidyl Inositol

..

Cholinesterase

Among the most common acetylcholinesterase inhibitors are phosphorus-based compounds, which are designed to bind to the active site of the enzyme.

..

everything prion is doing has to do with making Phosphorus toxic, just like this very specific Inhibitor.

Phosphodiesterase says Inhibitor, but i think what it really means is that it inhibits the Phosphorus malfunction or Oxidation.

and this is what snake venom does, disrupts the exact same enzymes.

so essentially snake venom & prion are doing the same thing.

Glyphosate is doing like Prion, binding Phosphorus into toxic waste.

Sulfur Toxicity
Hyperhomocysteinemia
Cysteine
Phosphorus Toxicity
Choline
Trimethylaminuria
Nitrogen Toxicity

at the perfect balance between Nitrogen & Sulfur is Choline, the main molecule in the previous list of Phosphorus Toxicity.

..

Lipolysis
Lipogenesis

(LRP1)
Low density Lipoprotein Receptor-Related Protein 1

(VLDL)
Very Low-Density Lipoprotein

(sLRP)
Soluble Low-Density Lipoprotein Receptor-Related Protein

Lipolysis is the metabolic pathway through which lipid triglycerides are hydrolyzed into a glycerol and free fatty acids.

Lipogenesis is the conversion of fatty acids and glycerol into fats, or a metabolic process through which acetyl-CoA is converted to triglyceride for storage in fat.

Very-low-density lipoprotein (VLDL), density relative to extracellular water, is a type of lipoprotein made by the liver. VLDL is one of the five major groups of lipoproteins that enable fats and cholesterol to move within the water-based solution of the bloodstream.

Soluble low-density lipoprotein receptor-related protein (sLRP, LRP-515) is a biological substance naturally produced by the human body. This protein has been found to bind to and neutralize anywhere from 70 to 90 percent of the amyloid-beta peptide that also naturally circulates in healthy human or mouse plasma. Impairment of this function is strongly associated with, and may soon be shown definitively to be the principal cause of, Alzheimer's disease.

..

https://en.m.wikipedia.org/wiki/Lipolysis

https://en.m.wikipedia.org/wiki/Lipogenesis

https://en.m.wikipedia.org/wiki/LRP1

https://en.m.wikipedia.org/wiki/Very_low-density_lipoprotein

https://en.m.wikipedia.org/wiki/Soluble_low-density_lipoprotein_receptor-related_protein

..

Low-density lipoprotein receptor-related protein 1: a physiological Aβ homeostatic mechanism with multiple therapeutic opportunities

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3432694/

The Role of the Cell Surface LRP and Soluble LRP in Blood-Brain Barrier Aβ Clearance in Alzheimer’s Disease

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2895311/

Voltage-gated calcium channel α 2δ subunits: an assessment of proposed novel roles

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6249638/

Therapeutic Effects of Amino Acids in Liver Diseases: Current Studies and Future Perspectives

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6619856/

A potassium chloride to glycine betaine osmoprotectant switch in the extreme halophile Halorhodospira halophila

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7042295/

Understanding mitochondrial potassium channels: 33 years after discovery

https://www.frontierspartnerships.org/articles/10.3389/abp.2024.13126/full

Potassium Intake, Bioavailability, Hypertension, and Glucose Control

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4963920/

SARS-CoV2 Infection and the Importance of Potassium Balance

https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2021.744697/full

..

Low Density Lipid-protein from liver desolve amyloid?

a natural Osmolyte manufactured by the liver, that disolves amyloid & possibly unfolds prion?

and has a direct link to Insulin.

..

Potassium Laurate

https://en.m.wikipedia.org/wiki/Potassium_laurate

used as a fungicide, insecticide, and bactericide

..

highest Potassium foods:

Avocado
Apple
Apricot

Carbohydrate (sugar)
Fatty Acid (oil)

seems like high Potassium foods rich in Carbohydrates & fatty acid Oils, also manufacturers some kind of Low Density Lipid-protein from the Liver, that functions like an Osmolyte, in that it unfolds misfolded proteins & disolves Amyloid.

because im noticing some powerful effects with the vinegar honey & potassium combination.

took my blood pressure down 20 points on both sides, and skin & hair is very smooth.

had sodium bile duct buildup, it was knocking away what little Potassium was there, never realized Potassium would fix that.

LRP1 the liver is making this to neutralize amyloid.

the liver is where potassium (and all other salts) is used with carbohydrate & fats to make very unique compounds.

because what im noticing, the vinegar & honey, qnd specifically with Potassium, is making a sweet oil in my sweat, that makes my skin & hair soft, like a protein relaxer, is the best i can explain.

back to the Avocado analogy, high in Nitrogen (B-Vitamins), Oils & Potassium.

..

Brown Vs White Fat
Digestive Salts
Potassium (carbohydrate)
Sodum Protein (meat)

https://healthnews.com/nutrition/weight-management/brown-fat-vs-white-fat-all-the-questions-answered/

LRP1
Low Density Lipoprotein Receptor-Related Protein 1

Glycine
Glycinate
Glycerate
Amino-Acetic Acid
Sugar-Acid
Vinegar Honey
Potassium

Glycine: The Smallest Anti-Inflammatory Micronutrient

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10379184/

Multifarious Beneficial Effect of Nonessential Amino Acid, Glycine

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5350494/

Glycerate
https://www.sciencedirect.com/topics/chemistry/glycerate

..

Sugar-Acid
Amino-Acid
Amino-Sugar
Iminosugar

https://en.m.wikipedia.org/wiki/Glucuronic_acid

https://en.m.wikipedia.org/wiki/Proteoglycan

https://en.m.wikipedia.org/wiki/Uridine_diphosphate_glucose

https://en.m.wikipedia.org/wiki/Amino_sugar

https://en.m.wikipedia.org/wiki/Iminosugar

..

Enzymatic Electrosynthesis of Glycine from CO2 and NH3

https://onlinelibrary.wiley.com/doi/10.1002/anie.202218387

..

Alanine
Osmolyte

https://en.m.wikipedia.org/wiki/Alanine

https://en.m.wikipedia.org/wiki/Cahill_cycle

Amino-Sugar
Aminoglycoside
Lysozyme
Carboxylate
Glycoside Hydrolases
Glycosynthase
Exoglycosidase
Endoglycosidase

..

Vitamin-C
Liposomal
Choline
Trimethylglycine
Acetylcholine (ACh)

..

Insulin
Glucagon
Glycine

How Insulin and Glucagon Work

https://www.healthline.com/health/diabetes/insulin-and-glucagon

Glucose, insulin, and the carotid body chemoreceptors in humans

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6087880/

Glycine
Betaine
Choline
Inositol
Osmolyte
Lipotropic
Plaque
Cholesterol
Phosphorus
Calcium

CH3
Methyl
Methane
Alkane
Hydrogen
Wax Paraffin

NH2
Glycine Synthesis
Oxoacetic Acid
Carboxylic Acid
Glyoxylic Acid
Glycin
Oxime
Vinegar Acetate

Emerging therapeutic potential of glycine in cardiometabolic diseases: dual benefits in lipid and glucose metabolism

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6198663/

..

Glycine is both an Amino Acid & Osmolyte

Insulin & Glucagon Homeostasis

getting really good results with the honey & vinegar test, its making something like Glycine, or a proto-amino acid compound.

..

Glycine, serine, glutamine, and asparagine were associated with improved insulin sensitivity, whereas all other AAs were associated with decreased insulin sensitivity.

Glutamate, tyrosine, isoleucine, and alanine had the largest effect on the reduction of insulin sensitivity.

..

Prion
Amyloid
Type 3 Diabetes
Lipid Peroxidation
Lipotropic
Osmolyte
Methyl Doner

Choline
Betaine
Inositol

https://en.m.wikipedia.org/wiki/Type_3_diabetes

https://en.m.wikipedia.org/wiki/Lipid_peroxidation

https://en.m.wikipedia.org/wiki/Lipotropic

Lipotropic Agent

https://www.sciencedirect.com/topics/medicine-and-dentistry/lipotropic-agent

..

the way Diabetes & Amyloid create a plaque barrer from dead cells, blocking nutrients.

thats what the vinegar & honey is supposed to break up, by permeating, softening and via enzyme reactions desolove it.

just fine tuning the raito, more like 50/50, the honey is the medicine, vinegar is the electricity.

apparently 90% of Covid "loss of taste & smell" returns in 4 weeks, and 10% its permanent.

the idea of vinegar & honey was to make Glycine & Betaine Osmolyte amino-acids, to help mitochondria heal & repair faster.

not sure if it helped, or your just getting better at normal speed.

covid appears connected to some kind of prion (spike) like HIV, triggering acceleration of amyloid plaque, causing neurodegeneration.

antimalarial anticancer drugs possibly are effective because of microtubule pathways used to replicate, lock or bind parasites.

my idea was some kind of mitochondria or DNA parasite called Plastid endosymbiont.

an exotic Corallicolid Plastid may have been modified & fused with mycoplasma fermentans to make it contagious.

this is unconfirmed, just my opinion.

one thing i did find works is sea salt (electrolyte) in the vinegar honey kills candida & foot fungus almost instantly.

nothing worked on my my one toe, for years, a couple drops of that stuff and it was gone.

similar to how people use baking soda & sugar cancer cure, but a well rounded mineral complex works better, honey or sugar should be fine, but the vinegar puts lightning bolts in it.

my problem with baking soda is the Sodium knocks out Potassium, causing Hypertension with me.

what ive noticed, dont need much minerals with vinegar & honey, the vinegar seems to make them supercharged or monoatomic ions, meaning they absorb really well, just a pinch.

apple cider vinegar is an acid, but acts like an alkaline, because the natural minerals from soil are supercharged.

baking soda alkali seems to just neutralize digestion & raise sodium levels.

Plastid is an algae cell that lives as an symbiont in other lifeforms, usually helping as a kind of extremophile metabolism function, but in the wrong species becomes parasitic living within mitochondria & bone marrow, making toxic acids.

operating very similar to Candida.

and the key element thatvis used to make toxic acids is Phosphorus, which is very important for biological functions, but if misfolded incorrectly makes amyloid plaque by prion proteins.

its strange that the right kind of sugars are so beneficial for lipid & carbohydrate metabolism, meaning plaque.

with the vinegar & minerals alone it was helping against Candida, but was too hot, but with the honey & less minerals seems the right balance, can drink it more often without the hot side effects.

testing oversaturated vinegar with too much honey & minerals does appear to kill fungus & parasites via microtubules, but seems to slow down metabolism, meaning the acetic or citric acids need to be higher or high enough for the body to metabolize easily.

suspension is Acetylation with Calcium Magnesium causes Dephosphorylation of Prion.

..

Phosphorylation

Polymerization of Fabrinogen

Fibronectin
Phospholipid

Phosphorus
Sulphur
Sodum
Tin

https://en.m.wikipedia.org/wiki/Phosphorus_pentasulfide

https://en.m.wikipedia.org/wiki/Sodium_dithionite

https://en.m.wikipedia.org/wiki/Nickel_tetracarbonyl

Prebiotic chemistry: a review of nucleoside phosphorylation and polymerization

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9832566/

Sources, essentiality and toxicological profile of nickel

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8985085/

..

GPI (Inositol)
Glycosylphosphatidylinositol

DSPC (Choline)
Distearoylphosphatidylcholine

PI
Phosphatidylinositol

PC
Phosphatidylcholine

..

https://en.m.wikipedia.org/wiki/Distearoylphosphatidylcholine

https://en.m.wikipedia.org/wiki/Phosphatidylcholine

https://en.m.wikipedia.org/wiki/Lipotropic

..

Lipotropic compounds are those that help catalyse the breakdown of fat during metabolism. Without lipotropics, such as choline and inositol, fats and bile can become trapped in the liver, causing severe problems such as cirrhosis and blocking fat metabolism.

..

Anti – Prion Systems in Yeast and inositol polyphosphates

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7321833/

Kinetics of the glucose/glycine Maillard reaction pathways: influences of pH and reactant initial concentrations

https://www.sciencedirect.com/science/article/abs/pii/S0308814604006077

Spindle Apparatus
Mitotic Spindle
Microtubule
Fenbendazole
Benzimidazole
Mebendazole

https://en.m.wikipedia.org/wiki/Spindle_apparatus

..

Mebendazole works by selectively inhibiting the synthesis of microtubules via binding to the colchicine binding site of β-tubulin, thereby blocking polymerisation of tubulin dimers in intestinal cells of parasites.

Mebendazole has an impact on mammalian cells, mostly by inhibiting polymeration of tubulin dimers, thereby disrupting essential microtubule structures such as mitotic spindle.

Mebendazole sometimes causes diarrhea, abdominal pain, and elevated liver enzymes. In rare cases, it has been associated with a dangerously low white blood cell count, low platelet count, and hair loss,[12][13] with a risk of agranulocytosis in rare cases.

..

Mitosis, Focus on Calcium

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9247304/

Fundamentals of Cellular Calcium Signaling: A Primer

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6942118/

The complex nature of calcium cation interactions with phospholipid bilayers

https://www.nature.com/articles/srep38035

Calcium Dysregulation and Homeostasis of Neural Calcium in the Molecular Mechanisms of Neurodegenerative Diseases Provide Multiple Targets for Neuroprotection

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3122891/

Mitochondrial Calcium Deregulation in the Mechanism of Beta-Amyloid and Tau Pathology

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7564294/

Combination of calcium and magnesium ions prevents substrate inhibition and promotes biomass and lipid production

https://www.sciencedirect.com/science/article/abs/pii/S2211926416300637

Synthesis and Chemical and Biological Evaluation of a Glycine Tripeptide Chelate of Magnesium

https://pmc.ncbi.nlm.nih.gov/articles/PMC8122334/

Renal Control of Calcium, Phosphate, and Magnesium Homeostasis

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4491294/

..

Albumin
Amino Acid
Proteins
Hydrogen
Calcium
Ions
Osmotic Balance
Osmoregulation
Glycine Betaine

This inhibition could be relieved by addition of excess free calcium, completing the circle, and demonstrating a fundamental role for calcium in cell division.

High intakes of sodium, protein and potassium has been linked to an increase in calcium excretion through the urine, feces and sweat. Large intake of caffeine increases calcium excretion and inhibits absorption of calcium.

both hydrogen ions and calcium are bound to serum albumin, when blood becomes alkalotic, the bound hydrogen ions dissociate from albumin, freeing up the albumin to bind with more calcium and thereby decreasing the freely ionized portion of total serum calcium.

..

The 2-to-1 Calcium-to-Magnesium Ratio

https://www.nutritionalmagnesium.org/optimum-calcium-magnesium-ratio/

Mystery solved: Why seashells’ mineral forms differently in seawater

Century-old riddle about aragonite formation is unraveled by scientists’ atomistic simulation.

https://news.mit.edu/2015/why-seashell-mineral-forms-differently-in-seawater-0302

..

Preparation method of fenbendazole

https://patents.google.com/patent/CN103242238A/en

https://en.m.wikipedia.org/wiki/Colony-stimulating_factor

..

Glycan
Polyporaceae
Polysaccharide

Turkey Tail Mushroom
Coriolus Versicolor

PSP
Polysaccharide Peptide

PSK
Polysaccharide Krestin

Immunomodulatory Properties of Coriolus versicolor: The Role of Polysaccharopeptide

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5592279/

Trametes versicolor (Coriolus versicolor) Polysaccharides in Cancer Therapy: Targets and Efficacy

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7277906/

Calcium Pantothenate

Calcium in Biology
Calcium Metabolism
Bone Remodeling
Bone Remodeling Period

Endoplasmic Reticulum
Calcium ATPase
Polyphenol
Glycine

Ribosome
Ribosomal RNA
mRNA Translation
Cotranslational Folding

https://en.m.wikipedia.org/wiki/Calcium_metabolism

https://en.m.wikipedia.org/wiki/Calcium_in_biology

https://en.m.wikipedia.org/wiki/Bone_remodeling

https://en.m.wikipedia.org/wiki/Bone_remodeling_period

..

https://pubchem.ncbi.nlm.nih.gov/compound/Calcium-pantothenate

Pentothenate is a component of coenzyme A (CoA) and a part of the vitamin B2 complex.

B5 is a growth factor and is essential for various metabolic functions, including the metabolism of carbohydrates, proteins, and fatty acids. This vitamin is also involved in the synthesis of cholesterol, lipids, neurotransmitters, steroid hormones, and hemoglobin.

..

Inhibition of Voltage-Gated Calcium Channels as Common Mode of Action for (Mixtures of) Distinct Classes of Insecticides

https://academic.oup.com/toxsci/article/141/1/103/2338224?login=false

Calcium Channels as Molecular Target Sites of Novel Insecticides

https://www.sciencedirect.com/science/article/abs/pii/B9780123943897000053

Calcium binds faster to both inorganic and organic anions due to its variable degree of hydration, rapidly exchanging water molecules per calcium ion. Calcium ions readily form almost insoluble salts with phosphates.

The complex nature of calcium cation interactions with phospholipid bilayers

https://www.nature.com/articles/srep38035

Bone Remodeling and Energy Metabolism: New Perspectives

https://www.nature.com/articles/boneres20135

Medication-Induced Repigmentation of Gray Hair

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6995950/

..

Bone vs Chitin Remodeling
Phosphorylation
Nitrogen vs Calcium

some kind of Plastid-Protist slime mold or corallicolid symbiont disrupting Bone Remodeling by switching Phosphorylation from Calcium for Nitrogen, making Prion Spike Amyloid-Chitin Plastic or Plaque, or Bioplastic Intelligent or synthetic blood.

Blue Blood is possibly a result of Cannibalistic evolution, triggering latent gene symbiont (FNA Parasites) to convert Aerobic-Oxygen Respiration & Metabolism into Anaerobic (non-oxygen-requiring).

..

How brainless slime molds redefine intelligence

https://www.nature.com/articles/nature.2012.11811

Biologists currently classify slime molds as protists, a taxonomic group reserved for "everything we don't really understand.

Plastid Transformation: New Challenges in the Circular Economy Era

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9736159/

..

HIV in Mycoplasma Incognitus & Covid, its using all the same blueprint, ticking timebomb.

Corallicolid is a Malaria of Coral Reef, living underneath the Calcium, just like our bone marrow.

..

all of this Bone Remodeling, something to do with the bone & marrow.

spike enters the brain from the skull, skeletal leaking.

..

Nonlinear dynamics of multi-omics profiles during human aging

https://www.nature.com/articles/s43587-024-00692-2

..

Apicomplexa
Toxoplasma

the chitin-binding-like domains of Toxoplasma possess lectin properties that play a pivotal role in host cell binding

Many protozoans have chitin and glucan cyst walls and the Cryptosporidium wall is labelled by various lectins

The cyst wall is built from chitin and glycoproteins secreted by the parasites

Chitin is a significant portion of the cyst wall of different Entamoeba species ... Heterokont alga, ciliates, Apicomplexa, dinoflagellates, haptophytes, and cryptomonads have engulfed red algae, and euglenids engulfed green algae during evolution

..

Mycoplasma and mycoplasma-like agents of human, animal, and plant diseases [1973]

https://archive.org/details/mycoplasmamycopl00mara/page/n4/mode/1up

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the only rules for taking Calcium is that its buffered with Citrate & Magnesium.

and on an empty stomach, because might slow digestion.

the raito is ..

1 part Magnesium
2 part Calcium

600 mg Calcium
300 mg Calcium

the mineral complex i was using with vinegar & honey, its high in all the other minerals, and low in the most important ones, Calcium, Potassium & Magnesium.

i just assumed they had the raito correct, Potassium is only allowed %1 by law, much lower then required, and they just ignored Calcium all together.

so not a complete mineral complex.

too much Potassium or Magnesium knocks out Calcium, and without Magnesium the Calcium dosnt work correctly.

Niacin Inositol & Betaine Glycine are two examples of how Nitrogen & Carbon work together as a neuroprotective Osmolytes, an example how Calcium & Nitrogen in the form of B Vitamins is calcium pantothenate, used for infant formula, skin & hair regeneration.

Osmolyte is a compound deep sea lifeforms make to protect themselves from extreme environments, fish oil (or wax) from Glycine (Carbon) & Nitrogen.

Calcium has the ability to dehydrate toxic lipids into a oil/wax.

the enire reason for B-Vitamins is for Nitrogen convert Carbon Carbohydrates into ATP for mitochondrial metabolism, yet excess B Vitamins only converts a limited amount before effect stops.

Calcium seems to have the ability to convert latent Nitrogen into functional ATP into Lipid Metabolism, bypassing excess Nitrogen supplements.

i think this malaria-like (possibly corallicolid) is displacing Phosphorus from Calcium & making Chitin microtubules amyloid plaque.

all of this is is mislabeled virus or genetic disorders.

displacing Calcium by relocating Phosphorus onto Nitrogen, to make Chitin, meaning converting bone into toxic levels of ionized Calcium causing cell death, and stealing Nitrogen from ATP metabolism to manufacture Chitin cysts & plaque.

making it appear Calcium & Nitrogen are the problem, and they are being flipped around into something toxic.

this parasitic is also very sensitive to the same two elements in the correct homeostasis polarity.

New Guinea (Kuru) in the most eastern point of the Coral Triangle, nearest to the deepest part of the Pacific Ocean.

for graphene to br come magnetic, might need to bind to iron from heme?

the original idea is mycoplasma laboratorium was made to break up ocean oil spills, capable of converting carbon into a bound solid state.

carbon binds calcium & iron, because coffee chelates them as well, from the phenol (carbon) binds them.

wonder if prion misfolding is done by removing a Calcium ion from the protein fold?

kind of like a tick has multiple infections that get smaller & smaller endosymbionts, like Russian dolls, into blood cells, mitochondria, bone marrow.

they mimic & go dormant, much like Candida, its fungus-like, but not a invertebrate it just travels inside them.

its very sensitive to the exact environment, gain of function is taking this plasmid from an animal mitochondria, which was evolved to be part of the immune system, and altering it to live in humans.

needed more Calcium, Potassium & Magnesium, less of the other minerals, now its acting like Thiamine.

the way i know is high dose of B1 Thiamine makes a slight ear ringing for a couple of days, now the vinegar honey is doing this.

..

Mycoplasma Fermentans & Malaria Plastid Cell Acidosis, disrupting Magnesium Potassium Homeostasis, converting Calcium into misfolding, Endoplasmic Reticulum Lipid production & Protein folding, Nucleated Red Blood Cell ejected from Red Bone Marrow Parenchyma Cells into Prion Amyloid Plaque.

Calcium is required for protein folding, higher Potassium & Magnesium raito keep Calcium from hardening into self-assembling stones, Glycine & Nitrogen (Betaine) keep it flexible & mineral absorption from 10% to 90%, into Endoplasmic Reticulum.

Nucleated Red Blood Cell

Red Bone Marrow Parenchyma Cells

Mycoplasma-vector Malaria-hybrid Plastid in the marrow.

meaning that Mycoplasma Fermentans was used to hold Maleria symbiont Plastid into Plasmid-like state, making Maleria long infection airborne.

so completely bypassing the need for a Protozoa, Mosquito or Tick, so the infection is mitochondrial virus-like, not so much blood parasite.

Malaria has the Plastid algae-fungus that uses Peptides, like Prion Peptide?

my guess is its modified or exotic, like from deep ocean Coral Reef Malaria-like parasite Corallicolid, near New Guinea.

Corallicolid
Coral Triangle
Abyssal Zone
Mariana Trench
Abyssopelagic Symbiont

A previously undescribed parasitic symbiont of the annelid Scoloplos with apicomplexan-like traits, named ‘Symbiont X’, was specifically related to Chromera velia.

Symbiont X contains only the isoprenoid pathway, similar to piroplasms.

the deepest ocean, next to the largest coral reef, where Kuru was discovered, also found in deep water worms.

its a kind of exotic deep water Maleria Algae.

i suspect was mutated & put into mycoplasma fermentans.

and its altering Mitochondrial Endoplasmic Reticulum Calcium Homeostasis, like it does inside Coral Reef.

one of the clues was B5

Calcium, Nitrogen & Glycine are all attracted to one anther, like a magnet.

so thats Honey, Vinegar & Minerals, it triggers the latent Nitrogen into an Osmolyte.

unfolds misfolded proteins & refolds them back to the original state, by fixing the Calcium malfunction.

Coral Calcium with the natrual complex minerals (Magnesium) cures all chronic genetic diseases, back into homeostasis.

this exotic mitochondrial disease is very sensitive to Calcium & Magnesium.

must be why it manufactures toxic acids to relocate Calcium into deposits.

and the series of data & articles explaining how Calcium from Endoplasmic Reticulum is responsible for both Lipid & Protein folding.

Prion & Mycoplasma

vinegar or citric is the safest acid, the honey is the safest sugar, together make Glycine a sugar-acid, proto-amino acid Osmolyte, and seem to make minerals almost 100% bioactive.

from what i can understand, just taking Glycine Betaine & Calcium, Magnesium & Potassium combination will do this same thing, bypassing all the B multivitamins completely.

may have a biohack that cures it, Osmolyte properties of Glycine Betaine & Coral Calcium.

unfolds misfolded proteins & refolds them correctly.

a way to duplicate this using Honey, Vinegar, Calcium, Magnesium Potassium.

we already have enough latent Nitrogen to make the B Vitamins, like a zipper, 1-12.

the Honey, Vinegar & Minerals are interconnected like a Triangle.

Honey/Vinegar:
Sugar-Acid
Glycine
Proto-Amino Acid
Betaine/Inositol

Vinegar/Minerals:
Monoatomic Ions
Chelated Absorbic
Acid/Base
Nicotinate Inositol

GlyNAC is definitely powerful stuff, also with the Betaine, especially because Cysteine uses Thiazoline for synthesis, so does Thiamine, very specifically used for carbohydrate metabolism.

Glycosylation of Proteins, it works against that, reminds me of what is required for neutralizing Prion, specifically plaque in the brain.

having similar results with both Vnegar, Honey & Minerals as the Glutathione supplement GlyNAC (TMG-NAC).

Cysteine NAC seems to like B1 for carbohydrate metabolism.

got the honey & vinegar to completely disolve Calcium pills, when almost nothing does.

this only seems to occur if enough air (Oxygen) is left in the bottom, if its completely full of liquid, it will not break down.

Calcium seems to break down bioactive with 5 different kind of buffer binders (Magnesium, Oxide, Citrate, Ascorbate & Glycine).

otherwise its just not going to metabolize for mitochondrial repair.

Calcium needs twice as much Magnesium to make the perfect 2:1 raito, and Potassium may also be required for mitochondrial Ph Homeostasis.

Calcium is a tricky little beast, needs everything just right to behave correctly.

Prion forms in the same location as Calcium folds proteins within the mitochondria Endoplasmic Reticulum.

what i suspect this is doing is putting Calcium into a Osmolyte state, capable of unfolding & refolding proteins.

no other mineral salts seem capable of binding so many complex buffers, and doing so many direct functions.

took too much NAC couple days ago, makes you hot & sweat, exactly like Niacin & DMSO, but today i can smell everything very strongly, didnt know it did that.

when hydrogen peroxide is neutralized too quickly, it creates heat..

NAC (N-acetyl-L-cysteine) is commonly used to identify and test ROS (reactive oxygen species) inducers, and to inhibit ROS. In the present study, we identified inhibition of proteasome inhibitors as a novel activity of NAC. Both NAC and catalase, another known scavenger of ROS, similarly inhibited ROS levels and apoptosis associated with H₂O₂ (Hydrogen Peroxide).

some elements need to be Buffered & others Chelated.

seems like if not buffered, things like Sulfur or NAC will chelate out Magnesium.

so the recent conclusion is, that while NAC & MSM does appear to act as a proto B Vitamin compound that rejuvenates Glutathione, it may bind & extract Magnesium homeostasis.

things like Potassium & Sodium should be Ph buffered, and mineral elements that become hard like Calcium & Magnesium need an additional Chelate element, including Amino-Acids & Glycine.

for Honey, Vinegar & Minerals to be balanced it appear to require equal amounts of Calcium, Potassium & Magnesium, while Sodium requirement is still pending.

i noticed the last fer weeks after taking NAC & B-Vitamins, Nitrogen & Sulfur, my body temperature was going hot, not cooling down properly, took some extra Magnesium and everything seems to gone back to normal.

the general idea is some elements have an opposing polarity element, Magnesium is drawn to Sulfur, if not buffered together, Sulfur will Chelate it out of the body.

Chelated binding goes both way.

un-Chelated elements will Chelate out other elements from the body, both good minerals & heavy metals.

Chelated Minerals as supliments will help absorb better, from %10 to %80, usually with a Ph Buffer or even better is Amino Acid compounds.

the idea is for Honey, Vinegar to Chelate the Calcium, Magnesium, Potassium, possibly Sodium & Trace Minerals, into Ionophores to temporary bind Microtubule Pathways, similar to Fenbendazole & NAC (Sulfur, Nitrogen & Polyphenol Carbon), that dont contain any Minerals, using the bodies reserves, and possibly Chelating essential Minerals out.

Sugar-Acid is supposed to be both pre-Amino Acid Chelate & Ph Buffer.

Raccoon Juice

HVM
Honey Vinegar Minerals

SAM
Sugar Acid Minerals

couple of objectives for this project, cure all kinds of diseases, and the ability to metabolize toxic sludge governments feed to people.

all i see are complex exotic & expensive supplemental protocols, and specialized diet plans that cost a fortune, and 9ver a very long time may offer some results.

i want the cheapest, most effective silver bullet & the ability to eat anything & live very long lives.

Americans have the disadvantage of zero nutrition in food, replaced with pesticides, plastic fertilizers, fake plastic oils ect.. we dont have the mitochondrial knowledge of tools to rebound into a neutral state.

raccoons eat our garbage and still healthier then we are.

"A Central Role for Magnesium Homeostasis during Adaptation to Osmotic Stress"

fiddled with every Osmolyte kind of combination & seemed like something was missing, only until GlyNAC did it occur that Magnesium was missing.

the whole idea of Osmolyte is unfolding misfolded proteins & refolding them back to default.

Magnesium alone, un-buffered & un-chelated without Glycine, Nitrogen, Sulphur, ect.. is basically worthless.

Magnesium is responsible for 600 enzyme reactions, meaning it unlocks bonds similar to Thiamine, meaning they are likely required together.

Deregulation of Autophagy
Autophagic Vacuoles
Lysosomes
Phosphorylated
Phosphorylation
Calcium Channels
AMPK
Prion
Maleria
Corallicolid

Linking Cerebral Malaria Pathogenesis to APOE-Mediated Amyloidosis: Observations and Hypothesis

https://link.springer.com/article/10.1007/s12035-024-04366-3

Possible roles of amyloids in malaria pathophysiology

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5137859/

Lysosomal calcium signalling regulates autophagy through calcineurin and TFEB

https://www.nature.com/articles/ncb3114

Ca2+ signals critical for egress and gametogenesis in malaria parasites depend on a multipass membrane protein that interacts with PKG

https://www.science.org/doi/10.1126/sciadv.abe5396

Evidence for glycoprotein transport into complex plastids

https://www.pnas.org/doi/10.1073/pnas.1301945110

Mycoplasma invasion into host cells: An integrated model of infection strategy

https://onlinelibrary.wiley.com/doi/10.1111/mmi.15232

Mycoplasma fermentans
Binds to and Invades HeLa Cells: Involvement of Plasminogen and Urokinase

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC517474/

Regulation of calcium homeostasis and flux between the endoplasmic reticulum and the cytosol

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9218512/

Protein Folding in the Endoplasmic Reticulum

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3632058/

Thiamine Repletion, Calcium Management, and the Heart

https://hormonesmatter.com/thiamine-repletion-calcium-management-heart/

Protein Targeting to the Malaria Parasite Plastid

https://onlinelibrary.wiley.com/doi/10.1111/j.1600-0854.2007.00660.x

..

HIF (1a) Protein
Hypoxia-Inducible Factor
1 Alpha
Prion
Calcium

..

Tin disrupts Calcium protein folding & stability.

The presence of calcium is relevant for both folding and stability of many protein domains

Organiotin compound in antifouling coating material of boat and ship could result in sex distortion of marine organism,as well as disturbing their calcium metabolism

Evidence indicates that calcium homeostasis in the brain is sensible to Triethyltin (TET) exposure, as it is also capable of inducing noradrenaline spontaneous release in rat cultured hippocampal slices by altering the functioning of calcium channels

Apicomplexan-like parasites are polyphyletic and widely but selectively dependent on cryptic plastid organelles

https://elifesciences.org/articles/49662

The Mold, Protozoan, and Coelenterate Mitochondrial Code and the Mycoplasma/Spiroplasma Code (transl_table=4)

https://ncbi.nlm.nih.gov/Taxonomy/taxonomyhome.html/index.cgi?chapter=cgencodes#SG4

Apicomplexa
Apicomplexan
Apicoplast
Plastid
Polyphyletic
Mixotrophic Algae

Orbiniidae
Corallicolid
Coral Triangle
Abyssal Zone
Hadal Zone
Mariana Trench
Abyssopelagic Symbiont

A previously undescribed parasitic symbiont of the annelid Scoloplos with apicomplexan-like traits, named ‘Symbiont X’, was specifically related to Chromera velia.

Symbiont X contains only the isoprenoid pathway, similar to piroplasms.

Both Lankesteria and Symbiont X appear to lack plastid genomes. The distribution of control, signature plastid genes involved in polypeptide import, folding, and DNA replication in the plastid (cpn60, sDer-1, PREX), matches the presence of plastid metabolism and genomes.

Symbiont X is known only from light microscopy data but would be also readily classified as an apicomplexan based on crude characteristics: it parasitizes the gut of Scoloplos armiger polychaetes being attached to the host epithelium.

Scoloplos is a genus of annelids belonging to the family Orbiniidae.

Orbiniidae is a family of polychaete worms. Orbiniids are mostly unselective deposit feeders on marine detritus. They can be found from the neritic zone to abyssal depths.

..

Endosymbiont
Symbiont
Anaerobic
Heterotrophic
Mixotrophic
Obligate
Intracellular
Prokaryote
Mollicute
Mycoplasma

He postulated that the nucleus evolved from a prokaryote (mycoplasma), which was engulfed by an amoeboid cell homologous to the eukaryotic cytosol

Her host was a heterotrophic anaerobic prokaryote (perhaps similar to Mycoplasma), in whose cytoplasm an aerobic prokaryotic microbe (the proto-mitochondrion) was ingested, resulting in the evolution of an aerobic amoeboid organism

Adhesion is a crucial prerequisite for successful invasion and is orchestrated by the interplay between mycoplasma surface adhesins and specific receptors on the host cell membrane. Invasion relies heavily on clathrin- and caveolae-mediated internalization, accompanied by multiple activated kinases, cytoskeletal rearrangement, and a myriad of morphological alterations, such as membrane invagination, nuclear hypertrophy and aggregation, cytoplasmic edema, and vacuolization. Once mycoplasma successfully invade host cells, they establish resilient sanctuaries in vesicles, cytoplasm, perinuclear regions, and the nucleus

..

Abyssal fauna, benthic microbes, and organic matter quality across a range of trophic conditions in the western Pacific ocean

https://www.sciencedirect.com/science/article/pii/S0079661121000781

Triphenyltin Influenced Carotenoid-Based Coloration in Coral Reef Fish, Amphiprion ocellaris, by Disrupting Carotenoid Metabolism

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10820653/

..

Orbiniidae and Corallicolid Symbiogenesis from deep water Abyssal & Hadal zones, alternating from Calcium to Organotin.

Abyssopelagic
Anaerobic
Heterotrophic
Mixotrophic

..

Defining the Pathway of Worm-like Amyloid Fibril Formation by the Mouse Prion Protein

..

Lovecraft got Cthulhu from Crowley, who wrote a book about it many years previously, and Crowley got his data from John Dee from his mother in the previous cult.

location of Cthulhu in Mariana Trench as Abyssopelagic Symbiont from Coral Triangle from Orbiniidae worm into Corallicolid Apicoplast.

the original idea of demonic infection is parasites.

Apicoplast
Prion
Inositol
Poly-Phosphates
Phosphatidylinositol
Hexakisphosphate

Scrapie prion protein contains a phosphatidylinositol glycolipid

GPI-PLD protein may be involved in prion propagation

The synthesis of Phosphatidylinositol (PI) is limited to the Endoplasmatic Reticulum (ER), which is the largest membrane componement of the cell. This site also contributes the synthesis to the majority of phospholipids, namely phosphatidylcholine (PC), phosphatidylethanolamine (PE), phosphatidylserine (PS) and triacylglycerol (TG). The synthesis involves a series of enzymatic reactions.

Apicoplasts in plants and certain algae, the plastid exports lipids to the rest of the cell and is the sole site of fatty acid biosynthesis. A fatty acid, or lipid, could thus be the mysterious “factor X” proposed to be produced by Toxoplasma apicoplasts, and perhaps such lipids are an essential component for parasitophorous vacuole formation.

..

Atypical lipid composition in the purified relict plastid (apicoplast) of malaria parasites

https://www.pnas.org/doi/10.1073/pnas.1301251110

Nuclear-encoded proteins target to the plastid in Toxoplasma gondii and Plasmodium falciparum

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC22835/

Infectious Speciation Revisited: Impact of Symbiont-Depletion on Female Fitness and Mating Behavior of Drosophila paulistorum

https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1001214

formerly designated Mycoplasma-like organisms are most likely Wolbachia that have evolved by becoming essential mutualistic symbionts in their respective natural hosts

..

Mycoplasma fermentans
Binds to and Invades HeLa Cells: Involvement of Plasminogen and Urokinase

HeLa cells have 76 to 80 chromosomes, whereas normal human cells have 46.

Formerly designated Mycoplasma-like organisms are most likely Wolbachia that have evolved by becoming essential mutualistic symbionts in their respective natural hosts.

..

Parasite and cancer cells are similar in their capacity to survive and proliferate independently of exogenous growth factors, to be resistant to apoptosis, and to evade host immune mechanisms.

Besides parasites that can cause cancer directly, there are also parasites that can indirectly stimulate cancer development through various mechanisms.

..

whats the chances Mycoplasma, Malaria Apicoplast & Prion Peptide have a Inositol-Phosphate connection directly to the Endoplasmic Reticulum?

and whats the chance mycoplasma also directly interacts with Endoplasmic Reticulum?

https://pubmed.ncbi.nlm.nih.gov/34078958/

..

ultimately, from what i can understand, Osmolyte is a kind of Lipid Wax that protects mitochondria from misfolding proteins.

combine deep ocean extremophile symbionts & DNA with mycoplasma Fermentans, that would be why Osmolytes may be something to look at, and a mitochondria parasitic symbionts misfolding mammalian mitochondria for something like sea vent worm ect..

like Frog Xenobot derived from the skin cells of frog embryos, is likely operating with Endosymbiont & Osmolytes.

what i think is happening, inside the mitochondria is converting healthy lipid metabolism, into a kind of chitin-like "spike" prion microtubules network, by rearranging CHONS.

lipid & carbohydrate metabolism being corrected is the medicine, and destroys the "virus" or "spike", and breaks down the Amyloid (Chitin) biofilm or plaques.

the reason GlyNAC & Magnesium is so powerful, is because its operating like Thiamine, Betaine & Magnesium, also much like Fenbendazole, dewormer.

Neutralize Hydrogen Peroxide
Magnesium

Hydrogen peroxide will naturally decompose into water and oxygen when exposed to sunlight, but it can also be rendered inert by adding oxalic acid, active carbon or many other mild acids. Hydrogen peroxide is more basic than acidic, so if it is necessary to neutralize it faster than it would automatically neutralize in sunlight, one must add some type of acid to bring its pH level value closer to 7.

..

Calcium
(Ca²+)
(NAC)
(ROS)
(SOCE)

ROS and SOCE: recent advances and controversies in the regulation of STIM and Orai

https://physoc.onlinelibrary.wiley.com/doi/full/10.1113/jphysiol.2012.230565

Calcium at the Center of Cell Signaling: Interplay between Endoplasmic Reticulum, Mitochondria, and Lysosomes

https://www.cell.com/trends/biochemical-sciences/fulltext/S0968-0004(16)30147-5

..

PUFA
Polyunsaturated
Fatty Acid
Lipid Peroxidation
Hydroperoxyl
Hydrogen Peroxide

https://en.m.wikipedia.org/wiki/Hydroperoxyl

https://en.m.wikipedia.org/wiki/Polyunsaturated_fat

https://en.m.wikipedia.org/wiki/Lipid_peroxidation

..

Luminal Ca2+
Ferroptosis
Tetraspanin MS4A15
Synaptotagmin
C2 Domain

MS4A15 drives ferroptosis resistance through calcium-restricted lipid remodeling

https://www.nature.com/articles/s41418-021-00883-z

The release of calcium from the endoplasmic reticulum induced by amyloid-beta and prion peptides activates the mitochondrial apoptotic pathway

https://www.sciencedirect.com/science/article/abs/pii/S0969996108000284?via%3Dihub

Alpha synuclein aggregation drives ferroptosis: an interplay of iron, calcium and lipid peroxidation

https://www.nature.com/articles/s41418-020-0542-z

Alpha-synuclein fragments trigger distinct aggregation pathways

https://www.nature.com/articles/s41419-020-2285-7

..

everything from prion, seed oil, mycoplasma fermentans disrupting lipids.. everything is doing the same exact same thing, having to do with Iron, Calcium & mitochondria homeostasis.

Sarcalumenin (SAR) is an SR luminal glycoprotein responsible for Ca 2+ buffering

Impaired Ca2+ reuptake into the sarcoplasmic reticulum (SR) underlies a primary pathogenesis of heart failure in the aging heart

..

Aggregation of alpha-synuclein (αSyn) is a crucial event underlying the pathophysiology of synucleinopathies.

Synucleinopathies are a group of neurodegenerative diseases collectively characterized by intracellular protein inclusions containing alpha-synuclein (αSyn). αSyn is a predominantly presynaptic, intrinsically unfolded protein of 140 amino acids. Its primary structure comprises three distinct domains: (i) an N-terminal domain that binds lipids and adopts alpha helical structures, (ii) a central domain known as non-amyloid component (NAC) involved in aggregation, and (iii) a C-terminal acidic tail.

..

Dietary magnesium and copper affect survival time and neuroinflammation in chronic wasting disease

"we found that higher Mg/Cu ratio resulted in significantly longer survival times after intracerebral CWD inoculation."

Magnesium in the Central Nervous System

Mg (Magnesium) levels were found to be decreased in various tissues of AD (Alzheimer’s Disease) patients and negatively correlated with clinical deterioration.

unfortunately Magnesium alone, un-buffered & un-chelated without Glycine, Nitrogen, Sulphur, ect.. is basically worthless.

..

Magnesium Status and Stress: The Vicious Circle Concept Revisited

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7761127/

Magnesium deficiency and oxidative stress

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5112180/

Magnesium Metabolism and its Disorders

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1855626/

Intracellular Mg2+ protects mitochondria from oxidative stress in human keratinocytes

https://www.nature.com/articles/s42003-023-05247-6

The Involvement of Mg2+ in Regulation of Cellular and Mitochondrial Functions

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5516748/

Telomere Homeostasis: Interplay with Magnesium

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5796106/

Association of Dietary Magnesium Intake With Leukocyte Telomere Length

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9161353/

Magnesium Oxide (MgO) Nanoparticles: Synthetic Strategies and Biomedical Applications

https://www.mdpi.com/2073-4352/14/3/215

A Central Role for Magnesium Homeostasis during Adaptation to Osmotic Stress

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8844918/

Mitochondrial Mg2+ homeostasis decides cellular energy metabolism and vulnerability to stress

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4960558/

Functioning of potassium and magnesium in photosynthesis, photosynthate translocation and photoprotection

https://onlinelibrary.wiley.com/doi/full/10.1111/ppl.12747

Effects of Magnesium Oxide and Magnesium Hydroxide Microparticle Foliar Treatment on Tomato PR Gene Expression and Leaf Microbiome (insecticide)

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8228823/

Exogenous Calcium Reinforces Photosynthetic Pigment Content and Osmolyte, Enzymatic, and Non-Enzymatic Antioxidants Abundance and Alleviates Salt Stress in Bread Wheat

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10097001/

Dietary magnesium and copper affect survival time and neuroinflammation in chronic wasting disease

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4981212/

Effect of Mg2 +, Ca2 +, Sr2 + and Ba2 + metal ions on the antifungal activity of ZnO nanoparticles tested against Candida albicans

https://www.sciencedirect.com/science/article/pii/S092849311500212X

Magnesium Oxide-Catalyzed Conversion of Chitin to Lactic Acid

https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/open.202000303

Why Thiamine Supplementation Requires Magnesium

https://hormonesmatter.com/why-thiamine-supplementation-requires-magnesium/

Functional Roles of Chelated Magnesium Ions in RNA Folding and Function

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8747768/

Cellular conditions of weakly chelated magnesium ions strongly promote RNA stability and catalysis

https://www.nature.com/articles/s41467-018-04415-1

the idea is viruses are symbionts, that mimic mitochondrial biological functions, and produce toxic acids, relocating calcium, misfolding proteins & ultimately prion amyloidosis & cancer.

symbionts are a very primitive form of bacteria-algae, possibly making carboxysome spores, that can go dormant.

in their normal environment are just fine, but fiddled around with in a laboratory & inserted into mycoplasma becomes a very complex problem.

Coral Reef symbionts called Corallicolida, an aquatic form of Maleria.

one of the original ideas was how antimalarial drugs seems to cure most cancers, parasites & general disease.

western chimpanzee & green monkeys from the most Malaria infections areas, and possibly the origin of Malaria.

my suspension is they evolved with Malaria, an immunity in the kidney & liver, basically immunity to HIV.

transfer that very specific symbiont into human blood, and get a new disease.

been focusing on Prions, because scientists have been speculating that it will be the interface between biology & computer interface for cybernetics, using amyloid prion & silicon, and Prion seems to have some roots with Toxoplasma (like from cats) to human brains, its a kind of Maleria symbiont, like Corallicolid.

the key elements disrupted seem to be Calcium & Magnesium from inside the mitochondria, acting similar to Glyphosate (roundup).

whats strange about unfiltered vinegar is its loaded with natural mineral electrolytes, making what seems an acid actually alkaline as well, the salts became monoatomic ions, and mixed with honey acts much like the "Baking Soda & Molasses kills cancer" thing, just much more powerful.

Osmolyte is the only thing i could find that reverses Prion misfolding, and its a very difficult subject to understand, because its happening at the atomic monoatomic levels.

been testing Osmolytes for quite awhile now, and discovered the buffered & chelated Minerals in Honey & Vinegar is acting as an Osmolyte, without the need for much extra B-Vitamins (Nitrogen & Sulfur) supliments, we already have enough latent in our bodies, doing nothing, can be converted over.

Mg2+ is the ionized, buffered, chelated or activated for of Magnesium.

whats the chances it neutralizes both Prion & Chitin?

the only reason Magnesium grabbed my attention its the only mineral that has Osmolyte properties, and obviously nobody is talking about Osmolyte, so had to do all the digging myself.

Dietary magnesium and copper affect survival time and neuroinflammation in chronic wasting disease

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4981212/

Magnesium Oxide-Catalyzed Conversion of Chitin to Lactic Acid

https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/open.202000303

..

Prion, Amyloid, Hydrogel, Nano-Chitin Biofilm

Fungus grow Chitin Microtubules, Malaria Apicoplast, same MEP pathways & cure as mycoplasma?

..

Symbiosis: Algae and fungi move from the past to the future

https://elifesciences.org/articles/49448

https://en.m.wikipedia.org/wiki/Glomalin

Glomalin is a hypothetical glycoprotein produced abundantly on hyphae and spores of arbuscular mycorrhizal (AM) fungi in soil and in roots.

Glomalin
Glycoprotein

[GRSP]
Glomalin-Related Soil Proteins

[MEP]
Methylerythritol Phosphate Pathway

MEP-α Gene
DGTT5 Gene

Mucoromycota's metabolism can utilize many substrates that are from various nitrogen and phosphorus resources to produce lipids, chitin, polyphosphates, and carotenoids.

..

The methylerythritol phosphate pathway as an oxidative stress sense and response system

https://www.nature.com/articles/s41467-024-49483-8

The MEP pathway: Promising drug targets in the fight against tuberculosis

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6997954/

Recent Advances in Chitin and Chitosan/Graphene-Based Bio-Nanocomposites for Energetic Applications

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8512808/

..

Eliquis
Apixaban

https://pubchem.ncbi.nlm.nih.gov/compound/Apixaban

Apixaban is a Factor Xa Inhibitor.

https://en.m.wikipedia.org/wiki/Factor_X

factor X deficiency may be seen in amyloidosis, where factor X is adsorbed to the amyloid fibrils in the vasculature.

Eliquis is being used for vaccine injuries?

Discovery and Development of Direct Xa Inhibitors

https://en.m.wikipedia.org/wiki/Discovery_and_development_of_direct_Xa_inhibitors

Discovery and Development of Direct Thrombin Inhibitors

https://en.m.wikipedia.org/wiki/Discovery_and_development_of_direct_thrombin_inhibitors

Coagulation Cascade

Coagulation cascade is a multi-step procedure where the main product thrombin is made by activating various proenzymes (mainly Serine Proteases) in each step of the cascade.

Thrombin has multiple purposes, but mainly it converts soluble fibrinogen to an insoluble fibrin complex.

Furthermore, it activates factors V, VIII and XI, all by cleaving the sequences selectively between Arginine and Glycine.

These factors generate more thrombin.

Thrombin also activates factor XIII that stabilizes the fibrin complex and therefore the clot and it stimulates platelets.

..

How Pfizer Makes Money

https://www.investopedia.com/articles/insights/080816/pfizer-7-secrets-you-didnt-know-pfe.asp

Pfizer ranked first in pharmaceutical companies for revenues from pharmaceutical-only products. The COVID-19 vaccine, COMIRNATY, the blood thinner ELIQUIS, and the pneumococcal vaccine PREVNAR combined made up 42% of the company's revenue.

Phosphorylation
Glycosylation Osmolyte Methylation
Osmolyte

Osmolylation

Phosphorylated
Amino-Acids:

Serine
Threonine
Tyrosine
Histidine

SV40
Polyomavirus
Bone
Brain
Astrocytes
Mesothelial Cells
Cellular Oncogenes
Bone remodeling
Bone Gomeostasis
Hexamer Protein
Dominant-Acting Oncoprotein
Retinoblastoma pRB
p53

..

https://en.m.wikipedia.org/wiki/SV40_large_T_antigen

https://en.m.wikipedia.org/wiki/Protein_phosphorylation

https://en.m.wikipedia.org/wiki/Pancreatic_ribonuclease_family

Two macrophages, osteoclasts and microglia: from development to pleiotropy

https://www.nature.com/articles/s41413-020-00134-w

Protein mimetic amyloid inhibitor potently abrogates cancer-associated mutant p53 aggregation and restores tumor suppressor function

https://www.nature.com/articles/s41467-021-23985-1

..

We produced transgenic mice by introducing a fusion gene (ST) comprising of the promoter for human serum amyloid P component (SAP) and the coding region of the simian virus 40 (SV40) large tumor antigen (Tag). The ST transgenic mice developed hepatocellular carcinomas (HCC).

SV40 large T antigen (Simian Vacuolating Virus 40 TAg) is a hexamer protein that is a dominant-acting oncoprotein derived from the polyomavirus SV40.

The transforming activity of TAg is due in large part to its perturbation of the retinoblastoma (pRb) and p53 tumor suppressor proteins.

Many of the DBD mutations, including the commonly occurring R248W/Q, R273C/H, and R175H10, involve replacing the cationic arginine, a so-called “gate-keeper” amino acid that prevents protein aggregation via the repulsive effect of its charge, with residues (tryptophan, glutamine, cysteine, or histidine) that have a high aggregation amyloidogenic potential.

The amino acids most commonly phosphorylated are serine, threonine, tyrosine, and histidine.

Agmatine is a cationic amine formed by decarboxylation of L-arginine by the mitochondrial enzyme arginine decarboxylase (ADC).

..

Cationic Arginine
Gate-Keeper

L-Arginine
L-Citrulline

Neuroprotective Cationic Arginine-Rich Peptides (CARPs)

Cationic Arginine-Rich Peptides (CARPs): A Novel Class of Neuroprotective Agents With a Multimodal Mechanism of Action

Arginine and Arginine-Rich Peptides as Modulators of Protein Aggregation and Cytotoxicity Associated With Alzheimer’s Disease

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8581540/

Arginine: Its pKa value revisited

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4420524/

Osmolyte-Induced Folding and Stability of Proteins: Concepts and Characterization

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7393045/

Arginine, lysine, and histidine are also known as common non-compatible osmolytes.

The unusual ability of the arginine side chain to retain its charge under all physiological conditions is not well understood. It is especially perplexing that an arginine remains cationic even when buried in the nonpolar hydrophobic core of a folded protein.

Some osmolytes are found to induce protein aggregation, and others inhibit aggregation of the same protein. For example, glycine and betaine aggregate RNase A while arginine suppresses aggregation.

..
Glucose > Glutamate
Glutamine > Citrulline > Arginine
Carbamoyl Phosphate

https://en.m.wikipedia.org/wiki/Ornithine

https://en.m.wikipedia.org/wiki/Carbamoyl_phosphate

Interorgan amino acid exchange in humans: consequences for arginine and citrulline metabolism

https://ajcn.nutrition.org/article/S0002-9165(23)27881-8/fulltext

Interrelationships between glutamine and citrulline metabolism

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4712452/

..

Glutamine is a precursor of ornithine, which can be converted to citrulline by the intestine; citrulline is transformed in the kidneys to arginine.

..

Tunable multiphase dynamics of arginine and lysine liquid condensates

https://www.nature.com/articles/s41467-020-18224-y

Biological importance of arginine: A comprehensive review of the roles in structure, disorder, and functionality of peptides and proteins

https://www.sciencedirect.com/science/article/abs/pii/S0141813023055459

Arginine and the Hofmeister Series: The Role of Ion-Ion Interactions in Protein Aggregation Suppression

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3110691/

L-Arginine hydrochloride increases the solubility of folded and unfolded recombinant plasminogen activator rPA

https://onlinelibrary.wiley.com/doi/10.1002/pro.465

Arginine Is Synthesized From Proline, Not Glutamate, in Enterally Fed Human Preterm Neonates

https://www.nature.com/articles/pr9201110

The Multifaceted Roles of Proline in Cell Behavior

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8397452/

Arginine and Proline Metabolism

https://en.m.wikipedia.org/wiki/Arginine_and_proline_metabolism

Asymmetric Dimethylarginine

https://en.m.wikipedia.org/wiki/Asymmetric_dimethylarginine

Arginine Signaling and Cancer Metabolism

Tumor cell-derived asymmetric dimethylarginine regulates macrophage functions and polarization

https://cancerci.biomedcentral.com/articles/10.1186/s12935-022-02769-7

NMDA Receptor

https://en.m.wikipedia.org/wiki/NMDA_receptor

Glutamate Hypothesis of Schizophrenia

https://en.m.wikipedia.org/wiki/Glutamate_hypothesis_of_schizophrenia

Musical Temperament

https://en.m.wikipedia.org/wiki/Musical_temperament

..

Tritone

core root note is C because the waveform reduces to 0/1=2

like when both large & small clovk hands overlap, 12 > 1 is also a chromatic octive.

12 ≈ C

0/1=2=4=8=16 [16Hz]

0
Nothing
Smallest

1
Everything
Largest

match key of C to our moment in time?

using C as the root note of galactic center, playing intervals of the 12 notes, can find the keystone of the center.

just wonder if we can detect the actual realtime we are in via Schuman Resonance of the Earth?

Tritone
The Devil's Chord

C = F#

C = Sagittarius
F# = Gemini

or even this will work

C = Ophiuchus
F# = Orion

..

what im ultimately getting at is the exact point to concentrate on.

0/1 the beginning & ending, realtime, out of time, that little window.

like how the Solfeggio Tuning is slightly off from Standard Tuning.

the idea is we are in some kind of out of phase timeline, and the true time is realtime, in the center point.

Augmented Triad, thats what i was looking for, im trying to possibly bypass the Tritone with a Triad, universe seems to like 3 points for stability.

there is only 4 Augmented Triad combinations, i think this is what im looking for, something strange, kind of like Tritone, but different, this is probably the clue to universe

you know what that seems to be doing, 0369.. all the 3 notes played together, pumping or making some kind of pulse wave.

yellow is inner space, purple is outer space, the other two seem to be almost a coronation system.

tested stacking Augmented Triads & discovered its literally the opposite polarity pattern as Tritone.

trying to understand it, but thats my point anyway, its so strange Augmented Triad is the opposite polarity as Tritone.

Aug Triad makes 4 possible Triangles & the Tritone is the most wrong note on the oppsite side.

how can this match up to an identical phenomenon?

can take a picture of both on guitar, how it is a mirror.

Aug Triad is 5 chromatic & Tritone is 7.

But the pattern is identical in mirror.

one moving forward & the other backwards, like DNA likes to spin a Right hand Spin & Left hand Spin.. amino acids that spin correctly are made into protein.

L vs D Anino Acids

one is leaning towards lower notes & the other towards higher notes?

its still a neat thing to ponder, how 5 & 7 want to move opposite directions.

playing them back to back still sounds fine, its just an oddly.

Augmented Triad triangulates itself into 4 combinations.

Tritone has 6 combinations, because its the opposite note.

Aug Triad = 4
Tritone = 6

yet they are somehow similar in function.

its the Tritone that wants into higher frequency.

Aug Triad is pushing to lower frequency resolution?

0/1=236
0/1=248

this is the foundational equation that separates Triangle from Square.

notice how 236 requires the 1 to multiply, while 248 does not.

thats my biggest point.
its difficult to explain.

0/1=2

yet as the number codes create algorithm, 0/1 is still just 1, only at first does it equal 2.

248 completely bypassing the 1 to multiply into triangulated numbers, yet it still only has 3 variations.

a paradox of creation, at the most fundamental level.

mandolin & violin tuning
5ths

guitar & bass tuning
4ths

meaning its a reverse scale, fingering goes backwards playing chord progression.

all that means is banjo & ukulele are usually tuned to a chord, making complex chord progressions difficult.

guitar can only allow 4 strings to be in 4th, before the fingers cant reach & needs to add that 3rd, to brind it back into key.

mandolin & bass are so far to reach all the chronic notes its actually makes the cords totally backwards to guitar.

Telomere
Tautomer
Prototropy

https://unacademy.com/content/upsc/study-material/chemistry/structural-requirements-of-tautomerism/

https://en.m.wikipedia.org/wiki/Dicarbonyl

https://en.m.wikipedia.org/wiki/Tautomer

https://en.m.wikipedia.org/wiki/Phosphonate

..

Glycation
Glycosylation

https://en.m.wikipedia.org/wiki/Glycation

https://en.m.wikipedia.org/wiki/Glycosylation

https://en.m.wikipedia.org/wiki/Glycosyl_donor

https://en.m.wikipedia.org/wiki/Glycosyl_acceptor

https://en.m.wikipedia.org/wiki/Chemical_glycosylation

https://en.m.wikipedia.org/wiki/Armed_and_disarmed_saccharides

https://en.m.wikipedia.org/wiki/Advanced_glycation_end-product

https://en.m.wikipedia.org/wiki/Alagebrium

https://en.m.wikipedia.org/wiki/Crosslinking_of_DNA

https://en.m.wikipedia.org/wiki/Alkylating_antineoplastic_agent

..

The term DNA glycation applies to DNA damage induced by reactive carbonyls (principally methylglyoxal and glyoxal) that are present in cells as by-products of sugar metabolism. Glycation of DNA can cause mutation, breaks in DNA and cytotoxicity. Guanine in DNA is the base most susceptible to glycation. Glycated DNA, as a form of damage, appears to be as frequent as the more well studied oxidative DNA damage.

..

Tartaric Acid and Tartrates in the Synthesis of Bioactive Molecules

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6214632/

https://en.m.wikipedia.org/wiki/Sherbet_(powder)

https://en.m.wikipedia.org/wiki/Reducing_sugar

..

[Sugar Acid]

[Acid Base]
Sherbet Powder

[Sugar Base]

..

A reducing sugar is any sugar that is capable of acting as a reducing agent. In an alkaline solution, a reducing sugar forms some aldehyde or ketone, which allows it to act as a reducing agent.

..

Osmolyte
Osmotic Shock
NMDA Receptor
Purinergic Receptor
Inositol
Taurine
Taurine-Transporting ATPase
Creatine
Betaine
Trimethylglycine
Choline
Sorbitol
Trehalose
Glycerophosphocholine
Hyponatremia
Osmotic Demyelination Syndrome
Neuroleptic Malignant Syndrome

https://en.m.wikipedia.org/wiki/Osmotic_shock

https://en.m.wikipedia.org/wiki/NMDA_receptor

https://en.m.wikipedia.org/wiki/Purinergic_receptor

https://en.m.wikipedia.org/wiki/Hyponatremia

https://en.m.wikipedia.org/wiki/Central_pontine_myelinolysis

https://en.m.wikipedia.org/wiki/Neuroleptic_malignant_syndrome

https://en.m.wikipedia.org/wiki/Glutamate_hypothesis_of_schizophrenia

https://en.m.wikipedia.org/wiki/Phenothiazine

..

Electrolyte Balance
https://open.oregonstate.education/aandp/chapter/26-3-electrolyte-balance/

Na1 Na2 Sodium Cation
Magnesium Osmolyte

The sodium ion affinities of asparagine, glutamine, histidine and arginine

https://www.sciencedirect.com/science/article/abs/pii/S1387380607003508

Molecular Mechanism of Ion-Ion and Ion-Substrate Coupling in the Na+-Dependent Leucine Transporter LeuT

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2576368/

Prokaryotic Solute/Sodium Symporters: Versatile Functions and Mechanisms of a Transporter Family

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7918813/

Interaction of GAT1 with sodium ions: from efficient recruitment to stabilisation of substrate and conformation

https://elifesciences.org/reviewed-preprints/93271

..

added Sodium (salt) that along with the Magnesium, Potassium, Calcium.

its fantastic, found some very complex papers explaining the Sodium Ion Cation Na1 Na2, supercharged from the sugar-acid.

eating salt is not the same thing, its different, monoatomic charged, instantly felt the difference, this is why only small changes for a month at a time, gives noticeable outcomes.

..

Hyperbaric Oxygen Therapy

Historical Aspects of Hyperbaric Physiology and Medicine

https://www.intechopen.com/chapters/66258

im not satisfied with the Honey, Vinegar & Minerals as it is, i will need to do the next step.

it seems likely that the Honey, Vinegar & Minerals needs to be heated up for a better Functional Amino bond.

add water & simmer down to cause a covenant bond, stabilize Ph.

The procedure known as the Strecker synthesis assembles an alpha-amino acid from ammonia (the amine precursor), cyanide (the carboxyl precursor), and an aldehyde. This reaction (shown below) is essentially an imino analog of cyanohydrin formation. The alpha-amino nitrile formed in this way can then be hydrolyzed to an amino acid by either acid or base catalysis.

If pure L or D enantiomers are desired, it is necessary to resolve these racemic mixtures. A common method of resolving racemates is by diastereomeric salt formation with a pure chiral acid or base.

meaning its not mixing well enough, needs to be more like bone broth, so still pending.

my suspension is its still too acidic, and the ideas is by low simmering it and by adding more water to cook down, will somehow fix the Ph by evaporating what is in excess, and make it more like amino acids, for protein synthesis, making it more like a food supplement & medicine.

i did this kind of experiment years ago, with minerals, citric & water, and ir does make the molecules combine, just never actually tested the outcome, honey (carbon) is the only new element, so might take me some time fiddling around with it.

the main idea is to become an enzyme activator, to break up toxic acids, biofilms, plaque, clear out & feed mitochondria, bind up parasites.

these things alone dont do it by themselves, Base: like baking soda, magnesium, or Acid like vinegar.

acid & base together without heat or cooking just falls apart before forming into amino acids into DNA & Protein.

so honey was kind of an attempt to bind them without heat or cooking, but apparently it also dosnt work.

the honey sugars will be important to making the very first bond for amino acids.

needs to be both an Amino Acid & Enzyme Activator, otherwise scrap the entire project.

its the last round im going to try before scraping it.

Carboxylic
Dicarboxylic
Tricarboxylic
Aminocarboxylic

..

still have one final test to do, that will give me an answer.

by combining mineral base with an acid like vinegar or citric, combined with sugar like honey, apparently is seems to need one final step, must be heated up with water to make the final covenant bond & stabilize the Ph.

water fixing Ph means by adding lots of water & simmering it down, will allow the Oxygen or Hydrogen to bind with acid or base, depending upon what is higher, and evaporate the rest out.

its just a hunch, because its not eqsy or really even possible to add Base & Acid, then perfectly stabilize the Ph, ive tried, it dont work.

adding lots of water & slowly cooking it down is ny next project.

if im correct is would make a foundation for amino-acids, and act as an enzyme activator.

ultimately in the end, i do think the medicine will work, just needs to be tested out more, for example, as a rule thumb never cook honey, yet using citric lemon with honey & cooked makes caramelized honey, so its still in the ballpark.

i just was hoping i didnt need to do that part, but have to test that as well.

my suspension is the 3 ingredients heated up together simmered down will create a kind of minimal oil.

cooking honey outside attracts lots of bees.

the sweet & acidic vinegar flavor is completely gone, now it tastes like malt, for brewing beer.

flavor changed completely, has a more barly then sweet flavor, adding water may not be a great idea, took hours to boil the excess out, because salt raises boiling time, making it hard to boil out, and the honey bees caught wind of it.

have another hunch, that by caramelization of sugar, salts * lemon, with an acids & base cooked make the carbohydrate carbon into something like C60 icosahedron shape.

C60 carbon would be a fantastic addition to the equation, but ultimately enzyme activator & amino acid activator, would reverse disease & aging.

C60 is manufactured when carbon & chloride are combusted with low oxygen, its very difficult to manufacture accurately, but my suspension that this Honey procedure is making something very similar.

it tastes like genger bread cookies? so far so good.

the Acidic & Sweet part is completely, and took a sip undiluted, yup salty ginger bread taste.

so far so good, seems to act like prune juice, cleans everything out, the Ph is stabilized so no stomach discomfort, hopefully it cleans the Liver, Gallbladder & Kidneys.

Fisetin.. i think this is what Caramelization of Honey, Vinegar & Minerals is making, via Modified Starch & Polyphenol Synthesis.

Polyphenol that hold the color spectrum of plants, light energy photosynthesis & DNA color structures, lights of color woven together in a hidden world within us.

Caramelization
Modified Starch
Polyphenol Synthesis

https://en.m.wikipedia.org/wiki/Caramelization

https://en.m.wikipedia.org/wiki/Modified_starch

The rate of caramelization is generally lowest at near-neutral acidity (pH around 7), and accelerated under both acidic (especially pH below 3) and basic (especially pH above 9) conditions.

..

Fisetin
vs
Lipofuscin
HMF

https://en.m.wikipedia.org/wiki/Fisetin

https://en.m.wikipedia.org/wiki/Hydroxymethylfurfural

https://en.m.wikipedia.org/wiki/Histamine_H1_receptor

https://en.m.wikipedia.org/wiki/Sirtuin

..

Impacts of selected dietary polyphenols on caramelization in model systems

https://www.sciencedirect.com/science/article/abs/pii/S0308814613008303?via%3Dihub

HMF causes anaphylactic symptoms by acting as a H1 receptor agonist

https://www.sciencedirect.com/science/article/abs/pii/S0006295220302367

5-HMF induces anaphylactoid reactions in vivo and in vitro

https://pubmed.ncbi.nlm.nih.gov/33102144/

Polyphenols: From Theory to Practice

https://pmc.ncbi.nlm.nih.gov/articles/PMC8621732/

..

Chalcone
Chalconoid
Anthocyanin

Polyphenol
Quercetin
Fisetin
Ellagitannin
Gingerol
Kaempferol
Resveratrol
Oleuropein
Secoiridoid

Indole Alkaloid
Tryptophan
Melatonin
Serotonin

https://pubchem.ncbi.nlm.nih.gov/compound/Fisetin

C15H10O6

https://pubchem.ncbi.nlm.nih.gov/#query=C15H10O6

https://en.m.wikipedia.org/wiki/Chalcone

https://en.m.wikipedia.org/wiki/Chalconoid

..

Arginine
Taurine

Life Extension

Biophotonics

https://en.m.wikipedia.org/wiki/Biophotonics

Interleukin 10

https://en.m.wikipedia.org/wiki/Interleukin_10

..

https://en.m.wikipedia.org/wiki/Amino_sugar

https://en.m.wikipedia.org/wiki/Aminoglycoside

https://en.m.wikipedia.org/wiki/Aminocyclitol

..

https://www.healthyandnaturalworld.com/health-benefits-of-apple-cider-vinegar-and-honey/

..

Sodium rutin ameliorates Alzheimer’s disease–like pathology by enhancing microglial amyloid-β clearance

https://pmc.ncbi.nlm.nih.gov/articles/PMC6393001/

Sodium Rutin

https://en.m.wikipedia.org/wiki/Rutin

Aryne Benzyne
Tetrahedral Molecule

The hexadehydro-Diels-Alder reaction: Benzyne generation via cycloisomerization of tethered triynes

https://pmc.ncbi.nlm.nih.gov/articles/PMC8008985/

https://en.m.wikipedia.org/wiki/Alkyne

..

Rutin is Quercetin Polyphenol.

been testing Polyphenol Synthesis by Caramelization of Honey with Vinegar (&/or Citric Acid).

its very powerful stuff, tastes like genger bread cookies, add some Sea Salt & GlyNAC to that, for a really interesting reaction.

the general goal was to make Amino Acids & Enzymes Activators, to feed mitochondria, but it may also be a medicine.

tried Honey, Vinegar & Mineral combinations for a few years, slowly testing the outcome, ultimately it must be boiled, otherwise it causes Ph problems.

no matter how much Base is added to the Acids, ultimately it never stabilizes, by cooking or caramelization the molecules bind & balance the Ph.

magnetic & superconducting properties C60 of carbon-alkali.

almost like Graphene, Benzene or Fulleride, but more like a supercharged, stabilized & reduced Polyphenol Tetrahedron molecule.

i dont particularity trust C60 because of the manufacturing methods, reduced oxygen combustion of Carbon & Chloride.

my idea is to mix everything together and cook it down into a charged Carbon putty.

acting as both a food supplement & medicine.

basically a supplement compound or molecule that is similar to Graphene & C60 electrically, but not for cybernetics, but for Telomere detoxifying & enhancing properties.

if the universe is electric & holographic, galactic web of charged plasma data transfer, thats the computer i want into.

Telomere & DNA electricity as an antenna for cosmic mind interface, if the enemy wants the worst kind of outcome, then i want the best possible outcome.

the structure of Peptide requires binding minerals complex, everything has to zip & lock together correctly.

Enzimes unzipping toxic acid sludge, Amino Acids zipping Telomeres, as a single unit compound.

this is two opposite directions of the same general idea.

making the medicine incorrectly would cause the opposite effect, instead of cleaning & repairing, would just make a bigger sticky binding mess.

the bad version having none, just Carbon & Oxygen alone.

this is mirroring everything to do with Osmolyte.

..

Honey
Vinegar
Minerals: (equil amounts)
Calcium
Magnesium
Sodium
Potassium

boiled together

remove bottom soot

add:

Niacin
Thiamine
NAC

..

most recent testing is finally giving me multiple good results without problems.

Honey (Molasses) 1/2 Cup
Vinegar (Citric) 1/2 Cup

Minerals:
1 Spoon Each

Calcium
Magnesium
Sodium
Potassium

Boil together,
then add 1 Spoon each

B1 Thiamine
B3 Niacin
NAC

..

pretty dang powerful, the Sugar, Acid & Salt Base need to be boiled together, the Ph just wont stabilize no matter what ratio.

i think it becomes a polyphenol like compound, but that alone is still not strong enough to finish the battle.

the B vitamins are just so powerful, but seem to need the Polyphenol & salts to become a medicine like Fenbendazole.

Cerebral Hypoxia
Anoxic
Hypoxic
Ischemic
Encephalopathy
Acidosis
Magnesium
Calcium

..

Neuroprotective effects of magnesium L-threonate

https://bmcneurosci.biomedcentral.com/articles/10.1186/s12868-020-00580-6

Polyphenols: Benefits to the Cardiovascular System in Health and in Aging

https://pmc.ncbi.nlm.nih.gov/articles/PMC3820045/

Magnesium and the Hallmarks of Aging

https://pmc.ncbi.nlm.nih.gov/articles/PMC10892939/

Mastocytosis and Mast Cell Activation Disorders: Clearing the Air

https://pmc.ncbi.nlm.nih.gov/articles/PMC8540348/

Liquid Breathing

https://en.m.wikipedia.org/wiki/Liquid_breathing

..

AMPK
AARSs

AMP-Activated Protein Kinase (AMPK)

Aminoacyl-tRNA Synthetases (AARSs)

Amino Acid Activation
Enzyme Activator

https://en.m.wikipedia.org/wiki/Amino_acid_activation

https://en.m.wikipedia.org/wiki/Enzyme_activator

..

MRPs
AGEs

Maillard reaction products (MRPs)
Advanced Glycation End Products (AGEs)

Effects of Maillard reaction and its product AGEs on aging and age-related diseases

https://www.sciencedirect.com/science/article/pii/S2213453024000028

..

Impact of polyphenols on mast cells with special emphasis on the effect of quercetin and luteolin

https://pmc.ncbi.nlm.nih.gov/articles/PMC6384425/

What is the Difference Between Histidine and Histamine

https://pediaa.com/what-is-the-difference-between-histidine-and-histamine/

MCAS
Mast Cell Activation Syndrome
Interleukin 10

https://mastcell360.com/mast-cell-and-histamine-safe-forms-of-magnesium-what-to-know-when-you-have-mast-cell-activation-syndrome-or-histamine-intolerance/

https://mastcell360.com/histamine-intolerance-vs-mast-cell-activation-syndrome/

..

Magnesium has an important role when it comes to mast cells and histamine.

It helps support DAO levels by reducing the amount of histidine (amino acid) that gets converted to histamine.

Histidine
Hhistamine

MCAS
Mast Cell Activation Syndrome
Interleukin 10

Toxic Acid
Oxalates
Lectin

DAO
Diamine Oxidase
Copper Enzyme

Polyphenol
Olive Oil
Oleuropein
Hydroxytyrosol

DMSO MSM
Magnesium Sulfate
Epsom Salt

Coral Reef
Calcium
Magnesium

..

Magnesium Calcium & Olive Oil for the Polyphenols.

all of the symptoms are directly connected to Histamine, medications are just expensive synthetic Polyphenols.

Ankylosing Spondylitis in bones, itchy skin rashes, enlarged prostate, sleeping problems.. all connected to Histamine.

its still the same line of thinking as Thiamine, is why Magnesium is required to make it work, but by actually knowing its a Histamine problem, hopefully can better pinpoint the exact process or enzyme blocks.

the only medication that helps is Zyrtec, but it only blocks the receptors, and dosnt reduce the Histamine, so its just a bandaid.

diet is just full of Histamine acids, that strip away Magnesium, and the way modern fertilizers work, has no Magnesium.

fermented foods are Histamine, so is Vitamin C & Citric Acid.

so thats why by boiling with the honey & minerals, lots of Magnesium, seems to make it more stable, the acid Ph is much reduced, and the idea is to convert the honey into a form of Polyphenol.

so that project is still pending in development.

might have it backwards, Honey Vinegar & Minerals cooked together is to do something like Fenbendazole, but im beginning to suspect much less Niacin, and more MSM, because the Niacin may be contributing to Histamine, which is good for an immune responce, but too much is Histamine.

so that will be part of the next test, see if i can figure out that balance, might be very little Niacin goes a long way, and needs Sulfur to balance.

not sure yet, slow process.

while it does appear to boost the immune system, killing colds, infections ect.. is also requires antihistamine for inflammation.

the opposite is Sulfur like DMSO MSM, Magnesium, Polyphenol Carbon with an Oil, so something like Olive Oil.

..

Small Intestinal Absorption of Methylsulfonylmethane (MSM) and Accumulation of the Sulfur Moiety in Selected Tissues of Mice

https://pmc.ncbi.nlm.nih.gov/articles/PMC5793247/

..

DMSO that included its antioxidant capabilities, antiinflammatory effects, anticholinesterase activity, and the ability to induce histamine release from mast cells

Sulfate
DMSO
MSM

Sulfoxide
Sulfonyl
Sulfone

Lignan
SDG
Secoisolariciresinol Diglucoside

Arylamine
Amine
Nitrogen
Benzene

Histamine
Homocysteine

Heparan Sulfate
Amyloid

Heparin-Induced Thrombocytopenia

Sulfate Maintenance Genes

Sulfation
Lipid Peroxidation

Heparan
C12H19NO20S3

Heparan Sulfate
C14H25NO21S3

..

DHA
Dehydroascorbic Acid

MSM
Methylsulfonylmethane

..

Evidence suggests that patients who are allergic to arylamine sulfonamides do not cross-react to sulfonamides that lack the arylamine group, and may therefore safely take non-arylamine sulfonamides. It has therefore been argued that the terms "sulfonamide allergy" or "sulfa allergy" are misleading and should be replaced by a reference to a specific drug.

A big reason that oxalates are so toxic is that each oxalate molecule that gets into our body will cause us to lose a molecule of sulfate.

Heparan Sulfates are the basis for a cascade of events leading to the formation of amyloid plaque.

..

Methionine Sulfoxide
Thioredoxin
Metallothionein
Hydrogen Peroxide
Phospholipid
Homocysteine

https://en.m.wikipedia.org/wiki/Methionine_sulfoxide

https://en.m.wikipedia.org/wiki/Thioredoxin

https://en.m.wikipedia.org/wiki/Metallothionein

..

Oxalate
DMSO

https://hormonesmatter.com/marginally-insufficient-thiamine-intake-oxalates/

https://bioindividualnutrition.com/oxalates-chronic-disease-comprehensive-guide-for-nutritionists/

https://www.beyondmthfr.com/side-high-oxalates-problems-sulfate-b6-gut-methylation/

https://newsnetwork.mayoclinic.org/discussion/mayo-clinic-researchers-find-way-to-prevent-accumulation-of-amyloid-plaque-a-hallmark-of-alzheimers-disease/

https://pmc.ncbi.nlm.nih.gov/articles/PMC9047184/

https://www.beyondmthfr.com/oxalates-and-mthfr-understanding-the-gut-kidney-axis/

https://bioindividualnutrition.com/oxalates-chronic-disease-comprehensive-guide-for-nutritionists/

..

Cytotoxic effect of Mycoplasma fermentans on mouse thymocytes

M G Gabridge

https://pmc.ncbi.nlm.nih.gov/articles/PMC415086/?page=1

https://en.m.wikipedia.org/wiki/Leukemoid_reaction

..

Leukemoid Reaction
Causes
Use of Sulfa Drugs

its not the Sulfate, but the Nitrogen causing the reactions.

..

Thrombocytopenia
Thrombocytosis

Mycoplasma pneumonia with severe cold agglutinin hemolysis, thrombocytosis, leukemoid reaction and acute renal failure

..

im still convenienced gain of function is exotic forms of malaria mixed with mycoplasma, plasmid into plastid.

and being malaria plastid is an ancient form of parasitic plant cell, it makes the opposite of healthy chemicals for mammals.

the ultimate "kind of" conclusion is that it makes something similar to Glyphosate.

im testing MSM again, whats interesting is it comes from sunlight evaporating sea water, goes into the atmosphere & rain is full of MSM.

only Magnesium & Sulfate breaks up Histamine, but the reaction can be so intense it appears a Sulfate intolerance, but its not from Sulfate, but from the detox reaction.

cooking food evaporates MSM Sulphur out, its very delicate to heat.

..

Epsom Salt
Magnesium Sulfate
MgSO4
Brain Injury
Inflammation

The role of magnesium in CNS injury

https://www.ncbi.nlm.nih.gov/books/NBK507262/

https://pmc.ncbi.nlm.nih.gov/articles/PMC5372953/

https://www.researchgate.net/publication/333140502_The_role_of_magnesium_sulfate_MgSO4_in_fetal_neuroprotection

..

STEPHANIE SENEFF, PHD

https://www.westonaprice.org/health-topics/abcs-of-nutrition/sulfur-deficiency/#gsc.tab=0

https://people.csail.mit.edu/seneff/

Stephanie Seneff is a Senior Research Scientist at the MIT Computer Science and Artificial Intelligence Laboratory. She received the B.S. degree in Biophysics in 1968, the M.S. and E.E. degrees in Electrical Engineering in 1980, and the Ph.D degree in Electrical Engineering and Computer Science in 1985, all from MIT.

Glyphosate pathways to modern diseases VI: Prions, amyloidoses and autoimmune neurological diseases.

Glyphosate, Deuterium, Prions and Neurodegeneration.

Glyphosate, Vaccines and COVID-19.

Glyphosate: An Overlooked Factor in Chronic Disease.

The Many Roles of Sulfate in the Body and its Disruption by Glyphosate

Sulfate is the most common nutritional deficiency that you never heard of.

Sulfate Deficiency in Neurological Disease Following Aluminum and Glyphosate Exposure.

Glyphosate's disruption of methylation/transsulfuration pathways as a key factor in autism and other diseases.

Glyphosate, Autism and Gut Dysbiosis.

A novel hypothesis for atherosclerosis as a cholesterol sulfate deficiency syndrome.

Sulfate deficiency throughout the body is behind most modern diseases and conditions, and how toxic chemicals in the environment, especially glyphosate, cause this deficiency.

Evidence that glyphosate is a causative agent in chronic sub-clinical metabolic acidosis and mitochondrial dysfunction.

The Possible Link between Autism and Glyphosate Acting as Glycine Mimetic.

Glyphosate's Suppression of Cytochrome P450 Enzymes and Amino Acid Biosynthesis by the Gut Microbiome: Pathways to Modern Diseases.

Is Encephalopathy a Mechanism to Renew Sulfate in Autism.

Is Cholesterol Sulfate Deficiency a Common Factor in Preeclampsia, Autism, and Pernicious Anemia?

Diminished brain resilience syndrome: A modern day neurological pathology of increased susceptibility to mild brain trauma, concussion, and downstream neurodegeneration.

..

Sulfide catabolism ameliorates hypoxic brain injury

https://www.nature.com/articles/s41467-021-23363-x

Thioredoxin Peroxidase Is a Novel Inhibitor of Apoptosis with a Mechanism Distinct from That of Bcl-2

https://www.jbc.org/article/S0021-9258(19)89587-X/fulltext

Amyloid
Heparan Sulfate
Heparin-Induced Thrombocytopenia
Sulfate Maintenance Genes

Heparin
C12H19NO20S3

Heparan Sulfate
C14H25NO21S3

..

Heparan sulfate proteoglycan in Alzheimer’s disease: aberrant expression and functions in molecular pathways related to amyloid-β metabolism

https://journals.physiology.org/doi/full/10.1152/ajpcell.00247.2022

..

this may be the strangest part of the mystery yet, look how similar they are, only 6 Hydrogen/Protons different.

almost as if something is manipulating the Sulfur attributes by rearranging the Hydrogen molecules.

my suspension is weaponized Corallicolid, corral malaria.

if someone could explain this mote clearly, so i can understand it better, then ide have a better chance to a simple cure.

off the top of my head, makes me want to knock out some of the Hydrogen molecules, Deprotonation.

Sulfate is good, and yet a Sulfur component is in Amyloid.

looking at the CHONS configuration, and only 3 elements of Sulfur, makes it unlikely to be the backbone of its configuration.

im suspecting Sulfate may be able to penetrate the Amyloid & disable it?

just not sure yet, but im back testing MSM again, see how it makes me feel, with tye Calcium, Magnesium, Omega & C.

kind of thinking Oxygen is an important part to this equation, in a good way, as if the Sulfate is charging the Oxygen to being accessible to the damaged areas, as neuroprotective, apposed to toxic reactions of ROS.

i have a suspension, regarding Allicin, Cannabinoids and the Sulfate connection.

and why seed oils, especially cooked, fried or heated up, and how sensitive Sulfur is to heat.

and how the best healthy oils have an abundance of Sulfur compounds.

..

Ketone Deprotonation Mediated by Mono- and Heterobimetallic Alkali and Alkaline Earth Metal Amide Bases: Structural Characterization of Potassium, Calcium, and Mixed Potassium−Calcium Enolates

..

Metal Binding to Sodium Heparin Monitored by Quadrupolar NMR

https://pmc.ncbi.nlm.nih.gov/articles/PMC9655979/

Sulfate
Fatty Acids
Metabolism

Sulfur Metabolism Under Stress

https://pmc.ncbi.nlm.nih.gov/articles/PMC7699002/

Physiological Roles and Regulation of Mammalian Sulfate Transporters

https://journals.physiology.org/doi/full/10.1152/physrev.2001.81.4.1499

CANNABINOID SULFATE ESTERS, THEIR SALTS AND USES THEREOF

https://patents.justia.com/patent/20230339850

Heparan Sulfate in the Developing, Healthy, and Injured Lung

https://pmc.ncbi.nlm.nih.gov/articles/PMC4942210/

Methylsulfonylmethane: Applications and Safety of a Novel Dietary Supplement

https://pmc.ncbi.nlm.nih.gov/articles/PMC5372953/

Glyphosate, pathways to modern diseases III: Manganese, neurological diseases, and associated pathologies

https://pmc.ncbi.nlm.nih.gov/articles/PMC4392553/

Effects of Methylsulfonylmethane on UVB-induced Skin Damage: An Experimental Study in a Mouse Model

https://pmc.ncbi.nlm.nih.gov/articles/PMC9677794/

Sulfate Reducing Microbes
Plastid Apicoplast Malaria
Anaerobic Respiration
Purple Earth Hypothesis
Retinal Retinaldehyde
Hypervitaminosis A

Sulfate assimilation in eukaryotes: fusions, relocations and lateral transfers

https://pmc.ncbi.nlm.nih.gov/articles/PMC2275785/

Phylogenomics Identifies a New Major Subgroup of Apicomplexans, Marosporida class nov., with Extreme Apicoplast Genome Reduction

https://academic.oup.com/gbe/article/13/2/evaa244/5988525?login=false

Origin of life: from luca to prokaryote

https://www.anec.org/en/biology/from-Luca-to-prokaryote.htm

The sunlight alter the conformation of retinal to pump hydrogen ions into the gap between the cell membrane and cell wall. The concentration gradient made hydrogen ions flow through ATP synthase to generate ATP. These early photosynthesis were based on the retinal that absorped green light, rather than chlorophyll, so other colors in sunlight gave the archaea a purple color.

..

https://en.m.wikipedia.org/wiki/Sulfate-reducing_microorganism

Sulfate-reducing microorganisms (SRM) or sulfate-reducing prokaryotes (SRP) are a group composed of sulfate-reducing bacteria (SRB) and sulfate-reducing archaea (SRA), both of which can perform anaerobic respiration utilizing sulfate as terminal electron acceptor, reducing it to hydrogen sulfide. Therefore, these sulfidogenic microorganisms "breathe" sulfate rather than molecular oxygen.

Anaerobic respiration is respiration using electron acceptors other than molecular oxygen.

..

so it appears Malaria is Sulfate Reducing via Anaerobic Respiration.

converts healthy Heparan Sulfate from lungs & brain into Amyloid plaque.

..

Shikimate
Glyphosate
Thioredoxin

if im correct, MSM Sulphur is specifically for healing the body only, not for killing any kind of parasites or pathogens.

MSM Methylsulfonylmethane, Omega3, VitaminC, Magnesium & Calcium seems to help heal the body.

but requires antimalarial drugs to kill the critter, things like Alkaloids with Nitrogen.

..

point to point looks like Malaria may be a very ancient pathogenic (possibly almost intelligent) plant cell, and requires Sulfur for respiration & metabolize, the byproducts disrupts Vitamin A metabolism, causing a cascade of other symptoms.

side effects of MSM is sleep difficulty & possible headaches because it breaks up Histamine, especially with Magnesium & Calcium.

MSM & Vitamin C work together by making it twice as powerful, meaning double the same symptoms.

MSM has much better symptoms then Vitamin B3, and likely has similar to better outcomes.

makes me think we already have an abundance of Nitrogen & decency in Sulfur is the actual problem.

..

Prasterone
Androstenolone
Epigenetic Clock

Vitamin A
Retinol
C20H30O

DHT
Dihydrotestosterone
C19H30O2

DHEA
Dehydroepiandrosterone
C19H28O2

DHEA-S
Dehydroepiandrosterone Sulfate
C19H28O5S

PREGS
Pregnenolone Sulfate
C21H32O5S

Cholesterol Sulfate
Hypervitaminosis

https://en.m.wikipedia.org/wiki/Hypervitaminosis

..

Effects of Methylsulfonylmethane on UVB-induced Skin Damage: An Experimental Study in a Mouse Model

MSM appears most effective for sun?

what that means is MSM makes the beneficial properties of A D & E more effective, thats basically what proves the next point.

makes me think how Methylene Blue has similar properties but is also possibly toxic, DMSO is doing the same thing yet much more safe, and MSM is a more stabilized form of DMSO.

while DMSO/MSM Sulfur appears to reverse toxic acid buildup from pesticides & parasites, is does not appear to directly kill or remove parasites or things like Malaria.

antiparasitic compounds will be the Nitrogen, Alkaloid, Polyphenol Carbon & Mineral Ions are the weapon.

that goes back to the testing of Honey, Vinegar, Minerals Caramelization.

got an idea to mimic this hot spring, leaving the parasite battle alone for awhile.

Himalayan & Sea Salt mixed in water, stur & let settle twice, first quickly for heavy metals, second for longer rest rare minerals sink & remove pour out excess Sodium.

Healing Lotion (Histamine)
DMSO, MSM, Magnesium, Castor, VitaminC, Trace Minerals

Parasite Purge
Honey, Vinegar, Minerals, Caramelization

..

Dimethyl sulfate and diisopropyl sulfate as practical and versatile O-sulfation reagents

https://www.nature.com/articles/s41467-024-46214-x

Brains, Bones, and Ponce de Leon: The Strange Story of Florida’s Only Natural Hot Spring

https://explorersweb.com/warm-mineral-springs-florida/

DMSO Could Save Millions From Brain and Spinal Injury

https://www.midwesterndoctor.com/p/dmso-could-save-millions-from-brain?fbclid=IwZXh0bgNhZW0CMTEAAR32bWT3R6iTFtlwI_6GEAbDyAsoEutaTfh3GZgVRwXowDG04_ShHtcs-wQ_aem_jEhxRb3CnG5RZAsc6TqBuw

A therapeutic combination of two small molecule toxin inhibitors provides broad preclinical efficacy against viper snakebite

https://www.nature.com/articles/s41467-020-19981-6

Dimethyl sulfide mediates microbial predator–prey interactions between zooplankton and algae in the ocean

https://www.nature.com/articles/s41564-021-00971-3

Sulfate Reducing Microbes
Plastid Apicoplast Malaria
Anaerobic Respiration
Plasmid Mycoplasma Vectors

Gain of Function with exotic forms of Malaria & Mycoplasma Vectors

Corallicolid Plastid combining Mycoplasma Fermentans Plasmid into Incognitus form of Pathogen

Ancient parasitic plant cells of Malaria Plastids mimic & convert healthy biological functions into toxic chemicals within mammal cells, similar to pesticide Glyphosate

Malaria Plastid a Sulfate Reducing Microbes via Anaerobic Respiration, converting healthy Heparan Sulfate from lungs & brain into Amyloid Plaque & complex forms of disease

Quinine works on the most common malaria, the first phase of infection reactions, but not the more exotic & dormant ones, at the complex levels it almost appears to wrap around the wires of DNA, its hard to explain chronic malaria.

Quinine killes the Protist but not the Plastid, its not easy to explain.

if this MSM, C & Quercetin starts giving me energy, got a theory building up, about this Plastid, Purple Earth Hypothesis, how Sulfur was the atmosphere, why Plastid is stealing the Sulfur, converting it into its toxic form, builds a Nitrogen Chitin-like biofilm, and appears MSM (has an Oxygen) also needs the Quercetin Polyphenol Carbon with a Citric or Vitamin C Oxygen to break it all down.

Plastid an old critter, also suspect it has this unusual attribute or a Brain without a Brain, the way it has memory & binds to DNA.

..

these are leaning towards Protist &/or Fungus..

Slime Mold
Sea Sponge
Cordyceps
Ophiocordyceps
Plasmodium
Physarum Polycephalum
Candida

but how do they transfer memory & neurons receptors?

i suspect its the an ancient Malaria that coexists within them, that has this unusual Brain without a Brain attribute.

might as well add Candida to the list, it behaves like a amoeba sea creature, moving around the body.

Secret life of Plants seems to prove the almost psychic powers of plants, they have the ability to communicate almost instantly.

that the general idea regarding Plastid cell.

not fungus, not insects, plants & animals.

..

Cellular origin of the viral capsid-like bacterial microcompartments

https://pmc.ncbi.nlm.nih.gov/articles/PMC5683377/

Oxidative Stress and Pathogenesis in Malaria

https://pmc.ncbi.nlm.nih.gov/articles/PMC8669614/

There Is Treasure Everywhere: Reductive Plastid Evolution in Apicomplexa in Light of Their Close Relatives

https://www.mdpi.com/2218-273X/9/8/378

Four core metabolic pathways are retained in the apicoplast: heme synthesis, iron–sulfur cluster synthesis, isoprenoid synthesis, and fatty acid synthesis.

LUCA
Last Universal Common Ancestor
Precell
Protocell
Protobiont
Nanobe
Apicoplast
Protoplasm

https://en.m.wikipedia.org/wiki/Non-cellular_life

https://en.m.wikipedia.org/wiki/Eukaryote

https://en.m.wikipedia.org/wiki/Pre-cell

https://en.m.wikipedia.org/wiki/Protocell

https://en.m.wikipedia.org/wiki/Nanobe

https://en.m.wikipedia.org/wiki/Protoplasm

..

plants are telepathic, suspecting so is the Apicoplast.

so it may be possible to communicate with the Apicoplast to protect, instead of make sick?

Apicoplast being an ancient plant cell, possibly having telepathic properties, just makes me wonder about plant based cybernetics using just that cell alone, healing properties like xman, instead of malaria.

thats kind of my guess, what might be going on, regarding bizarre genetic diseases & other uncureable disease, i think we are fighting something that can be almost programed by evolution, and should not be swapping around with other animals.

i think whats rattling around in my head is, viruses & prions are from this LUCA Nanobe, that can appear as Apicoplast, and its nearly indestructible, so must be trained to behave nicely, possibly by giving it what it wants, more Sulfur.

..

The Domain System

The Tree of Life consists of three domains, Archaea, Bacteria, and Eukarya.

Exclusion of Viruses and Prions

Non-Cellular Life
Virus and Prion

The Three-Domain System includes no form of non-cellular life.

Prionobiota (acellular and without nucleic acid)

Virusobiota (acellular but with nucleic acid)

Adipokine
Neuropeptide
Leptin
Adiponectin
Resistin

RSS
Reactive Sulfur Species
Organosulfide
Sulforaphane
Isothiocyanate
Allicin

Diallyl Disulfide
Dimethyl Sulfoxide
Methylsulfonylmethane
DMSO/MSM

Rhodanese
Thiosulfate
Sulfurtransferase

https://en.m.wikipedia.org/wiki/Leptin

https://en.m.wikipedia.org/wiki/Leptin_receptor

https://en.m.wikipedia.org/wiki/Reverse_triiodothyronine

https://en.m.wikipedia.org/wiki/Triiodothyronine

https://en.m.wikipedia.org/wiki/Adipokine

https://en.m.wikipedia.org/wiki/Adipose_tissue

https://en.m.wikipedia.org/wiki/Reactive_sulfur_species

..

Effect of Leptin on Chronic Inflammatory Disorders: Insights to Therapeutic Target to Prevent Further Cardiovascular Complication

https://pmc.ncbi.nlm.nih.gov/articles/PMC8296717/

Accumulation of Sulforaphane and Alliin in Human Prostate Tissue

https://pmc.ncbi.nlm.nih.gov/articles/PMC9415180/

A Whiff of Sulfur: One Wind a Day Keeps the Doctor Away

https://pmc.ncbi.nlm.nih.gov/articles/PMC9219989/

Therapeutic potential of organosulfur compounds in pulmonary hypertension

https://www.sciencedirect.com/science/article/abs/pii/S2213434424000082

Additional disulfide bonds in insulin: Prediction, recombinant expression, receptor binding affinity, and stability

https://pmc.ncbi.nlm.nih.gov/articles/PMC4420526/

..

Lipid Lamellae
Long-Chain
Fatty Acid
Sphingoid Bases

Skin Lipid Barrier: Structure, Function and Metabolism

https://pmc.ncbi.nlm.nih.gov/articles/PMC11450438/

Skin barrier function requires the presence of ULCFAs and long-chain sphingoid bases to create highly ordered and tightly packed lipid lamellae.

https://en.m.wikipedia.org/wiki/Sphingolipid

..

Adipokine
Adipokinetic Hormone
Anopheles Gambiae
Chitin Polymers
Chitinase-Like Proteins
Prions Amyloidosis

Adipokinetic hormones (AKHs) are metabolic neuropeptides, mediating mobilization of energy substrates in many insects.

The hormone itself is part of a larger family, often referred to as red pigment concentrating hormones (RPCH) discovered in crustaceans.

The spread of malaria by the female mosquito, Anopheles gambiae, is partly dependent on the adipokinetic hormone.

https://en.m.wikipedia.org/wiki/Adipokinetic_hormone

https://en.m.wikipedia.org/wiki/Anopheles_gambiae

..

Thiosulfate
Sulfurtransferase

Thiocyanate is produced by the reaction of elemental sulfur or thiosulfate with cyanide.

The second reaction is catalyzed by thiosulfate sulfurtransferase, a hepatic mitochondrial enzyme, and by other sulfur transferases, which together are responsible for around 80% of cyanide metabolism in the body.

Thiocyanate shares its negative charge approximately equally between sulfur and nitrogen. Thiocyanate can bind metals at either sulfur or nitrogen, an ambidentate ligand.

..

Uncovering a Cryptic Site of Malaria Pathogenesis: Models to Study Interactions Between Plasmodium and the Bone Marrow

https://pmc.ncbi.nlm.nih.gov/articles/PMC9201243/

The bone marrow is a critical site of host-pathogen interactions in malaria infection.

Tracking dormant malaria

https://www.sciencedaily.com/releases/2018/02/180222125635.htm

This dormant form is resistant to most antimalarial drugs and can reawaken months or years later, causing disease relapse.

Evaluation of Chiral Organosulfur Compounds on Their Activity against the Malaria Parasite Plasmodium falciparum

https://pmc.ncbi.nlm.nih.gov/articles/PMC9785921/

Relevant antimalarial activities were only observed for compounds with sulfur-based heterocycles. Among them were the two novel spirocyclic sulfondiimines.

polyphenols act as Pickering stabilizers at the water-oil interface.

Polyphenols act as Pickering stabilizers at the water-oil interface.

Stability of water-in-oil emulsions co-stabilized by polyphenol
crystal-protein complexes

..

Histamine
Chitin/Chitinase-Like Proteins
Amyloid Plaque

search Sulfur in an article, and Insulin showed up.

(Sul)fur
In(sul)in

Insulin Resistance = Amyloid Plaque

its just strange how this is connected to Malaria, thats what caught my attention, like its hyjacking our Adipokine & making plaque.

Adipokine
Adipokinetic Hormone
Anopheles Gambiae

and hopefully this means Malaria is sensitive to something like MSM or DMSO (kills malaria) & also breaks up the plaque, that would be nice.

suspect this Histamine, Chitin Plaque is related to Cyanide.

DMSO/MSM needs a Carbon Heterocycle (Polyphenol) like Quercetin.

and.. if Incognitus is somehow related to a Malaria, this same combination should work.

all these years trying different Nitrogens to combat it, come to find out its hiding inside a Nitrogen Chitin-like biofilm plaque, that only Sulfur & Polyphenol can break apart.

and is seems like Citric or C really kicks MSM into overdrive, and Oil might help make fat soluble.

im still having trouble mixing DMSO with Castor, using Citric Acid powder, so next test is adding the Quercetin powder, maybe this activated polyphenol Carbon will help mix Sulfur into Oil?

might just be MSM is better suited for this because its already stabilized, seems like DMSO is just to watery to mix with oil.

everything seems to do with Nitrogen arrangement, but we already have enough Nitrogen from food, so extra B Vitamins are not the answer, but how to rearrange from toxic acids & histamine to cellular regeneration.

seems the most effective way to rearrange Nitrogen is Polyphenol (Carbon) & Sulfur.

i cant prove it, but it just seems like to keep everything moving along correctly, requires double the intake of Sulfur then Nitrogen, almost liie Nitrogen regenerates more easily.

meaning this may be why B1 Thiamine requires Magnesium, because of the binding with Sulfur for regeneration.

both Sulfur & Nitrogen for plants natural fertilizer cycles come from rain.

but cooking food the Sulfur evaporates.

people with very high Histamine & the corresponding symptoms are sensitive to Sulfur & Magnesium, Epsom Salts, because of the rapid detoxification.

and the data regarding Sulfur Intolerance actually dosnt exist, but is a Nitrogen Histamine reaction.

my biggest concern regarding DMSO wa Cytotoxicity & DNA mutations, but in reality they are already mutated via Histamine, and the Sulfur softens up the misfolding back to default.

seems like the Sulfur needs a small Carbon molecule, so im trying both GlyNAC & Quercetin, see if it gets a boost, let you all know what happens.

reason is both water & oil have an abundance of Hydrogen, and it may be slowing down the reactions im looking for.

suspect the Polyphenol & Glycine Carbons may be more effective flipping enzymes.

..

Quercitrin Stimulates Hair Growth with Enhanced Expression of Growth Factors via Activation of MAPK/CREB Signaling Pathway

https://pmc.ncbi.nlm.nih.gov/articles/PMC7504764/

LUCA
Malaria
Apicoplast
Carboxysome
Microcompartments
Virus/Prion

..

Pyrenoid functions revealed by proteomics in Chlamydomonas reinhardtii

https://pmc.ncbi.nlm.nih.gov/articles/PMC5826530/

An example of intra-organellar compartmentalization is the pyrenoid in the chloroplasts of algae.

..

Cellular origin of the viral capsid-like bacterial microcompartments

https://pmc.ncbi.nlm.nih.gov/articles/PMC5683377/

Considering that BMC proteins have been detected in only ~17% of known bacteria and none in archaea, whereas PII proteins are among the most ancient, ubiquitous and versatile components of signaling systems in nature, it appears most likely that BMC-H proteins evolved from PII-like proteins. However, it cannot be ruled out that the two families of cellular proteins have diverged from a common ancestor in a more distant past.

Major shell proteins that form bacterial microcompartments (BMC) are structurally similar to ubiquitous cellular proteins, such as PII and IF-1, and in some cases can be linked to those by sequence similarity as well. They propose that BMC-H and BMC-P proteins originated from cellular proteins with ancient folds - ferredoxin-like (PII) and OB.

..

Integrated genomic and fossil evidence illuminates life’s early evolution and eukaryote origins

https://pmc.ncbi.nlm.nih.gov/articles/PMC6152910/

The oldest fossil remains that can be ascribed to crown-Eukaryota is ~1.1 Ga Bangiomorpha pubescens, which can be confidently assigned to the red algal total group (Rhodophyta).

..

Two proteins residing in the apicoplast membranes that together constitute a functional apicoplast pyruvate carrier (APC) to mediate the import of cytosolic pyruvate. Depletion of APC results in reduced activities of metabolic pathways in the apicoplast and impaired integrity of this organelle, leading to parasite growth arrest.

Mitochondrial Pyruvate Carrier

https://en.m.wikipedia.org/wiki/Mitochondrial_pyruvate_carrier_1

https://en.m.wikipedia.org/wiki/Mitochondrial_pyruvate_carrier_2

https://en.m.wikipedia.org/wiki/Pyruvate_dehydrogenase_complex

https://en.m.wikipedia.org/wiki/Pyruvate_dehydrogenase_deficiency

https://en.m.wikipedia.org/wiki/Inborn_errors_of_carbohydrate_metabolism

..

Red Algae
Purple Earth Hypothesis

Chloroplasts probably evolved following an endosymbiotic event between an ancestral, photosynthetic cyanobacterium and an early eukaryotic phagotroph. This event (termed primary endosymbiosis) is at the origin of the red and green algae (including the land plants or Embryophytes which emerged within them) and the glaucophytes, which together make up the oldest evolutionary lineages of photosynthetic eukaryotes, the Archaeplastida.

The life history of red algae is typically an alternation of generations that may have three generations rather than two. Coralline algae, which secrete calcium carbonate and play a major role in building coral reefs.

Red algae are divided into the Cyanidiophyceae, a class of unicellular and thermoacidophilic extremophiles found in sulphuric hot springs and other acidic environments, an adaptation partly made possible by horizontal gene transfers from prokaryotes, with about 1% of their genome having this origin, and two sister clades called SCRP.

All extant eukaryotes descend from the last eukaryotic common ancestor (LECA), which is thought to have featured complex cellular organization. To gain insight into LECA biology and eukaryogenesis—the origin of the eukaryotic cell, which remains poorly understood—we reconstructed the LECA virus repertoire. We compiled an inventory of eukaryotic hosts of all major virus taxa and reconstructed the LECA virome by inferring the origins of these groups of viruses. The origin of the LECA virome can be traced back to a small set of bacterial—not archaeal—viruses. This provenance of the LECA virome is probably due to the bacterial origin of eukaryotic membranes, which is most compatible with two endosymbiosis events in a syntrophic model of eukaryogenesis. In the first endosymbiosis, a bacterial host engulfed an Asgard archaeon.

..

Immortal Stem Cell
Embryonic Stem Cell Telomere DNA
Regeneration

Cross-species metabolomic analysis identifies uridine as a potent regeneration promoting factor

https://www.nature.com/articles/s41421-021-00361-3

Uridine
Pyrimidine Metabolism
Yamanaka Factors

EndoMac Progenitors

..

Apicomplexa is the Protist (Invertebrate) host, Apicoplast is the Plastid (Plant Cell).

all the complex classes & variation of species, is only the Protist, nothing mentioned regarding the Plastid, like its all the same thing, with different mitochondrial programming.

what this means is all living creatures are from this LUCA Plastid, also known as Malaria, possibly Nanobe (space spore), possibly the immortal cell line, can be programed or reprogrammed to do anything.

..

Many of these nucleus-encoded apicoplast-targeted (NEAT) proteins, especially non-transmembrane ones located in the lumen of the apicoplast, contain an N-terminal signal peptide.

The general mechanism of FeS formation in the mitochondrion and apicoplast involves pyridoxal-phosphate-dependent cysteine desulfurases which liberate sulfur (S0) from cysteine and transfer it to relay proteins in the form of a persulfide. The sulfur is then transferred to a scaffold protein (or proteins), where the FeS is formed with iron. Subsequently, the clusters are transferred to apoproteins via carrier proteins. Mitochondrial proteins rely on the mitochondrial ISC (iron-sulfur cluster formation) pathway and proteins in the cytosol and nucleus rely on the CIA (cytosolic iron-sulfur protein assembly) pathway.

something just came to mind.

how similar are the symptoms of Haemophilia to HIV?

meaning, is this the true origin of HIV, and the apes got it from scientists?

im just thinking, before HIV had a name, was it always known in history as Haemophilia, and before this name it was Blueblood disease?

wondering if DMSO is the only element that absorbs into ..

LUCA
Malaria
Red Algae
Sulfur Respiration

it may break up prion amyloid bonds?

meaning its only sensitive to Sulfur, everything else becomes armor.

i cant keep up with a single thought, or keep up with comments, but thats kinda the thought in the background.

royalty bloodlines brewed up HIV with all the blood ritual magic, Satanism or vampire blood disease.

somehow north-western Chimpanzee & green monkeys got involved with the Danzig/Congo Christian exhibitions.

ultimately i suspect its an ancient Malaria from LUCA, that retains genetic memory, and genetic disease.

..

Blueblood Disease
Haemophilia
HIV
Hepatitis
Malaria
Apicoplast

Timeline of HIV/AIDS

https://en.m.wikipedia.org/wiki/Timeline_of_HIV/AIDS

Haemophilia

https://en.m.wikipedia.org/wiki/Haemophilia

Infected blood scandal in the United Kingdom

https://en.m.wikipedia.org/wiki/Infected_blood_scandal_in_the_United_Kingdom

In the 1970s and 1980s about 6,000 people with haemophilia and other bleeding disorders were treated with contaminated clotting factors containing HIV and hepatitis viruses. Some of those unintentionally infected their partners, often because they were unaware of their own infection.

Up until late 1985 many people with haemophilia received clotting factor products that posed a risk of HIV and hepatitis C infection. The plasma used to create the products was not screened.

..

thinking about how Chuck mycoplasma infection seemed to have became out of dormancy or activated by Covid?

because the way the spike protein goes into the brain by leaching from skull bone marrow.

Spike & Incognitus both go to the bone marrow for dormancy, but it seems Covid can "wake up" dormant Incognitus.

Garth did that article about Covid & Mycoplasma cofactors & deadly outcome, but how can Spike & Incognitus have enough in common to "wake up" the other?

..

SV40
Apicoplast
Obligate

Cells take up solid particles using a process called endocytosis. How did scientists use viruses to learn about endocytic functions in cells?

https://www.nature.com/scitable/topicpage/how-viruses-hijack-endocytic-machinery-14364991/

thinking about both experiments, and the goals.

CBD/CBG derivatives are Carbon Polyphenol with Hydrogen Bonds.

Allicin is from Garlic & chemical almost identical to DMSO.

the two directions

Allicin DMSO Sulfur
Water Soluble:

DMSO: C2H6OS
MSM: C2H6O2S
Allicin: C6H10OS2

C60 CBG Carbon
Oil Soluble:

THC: C21H30O2
CBG: C21H32O2
Ricinoleic: C18H34O3

..

Decarboxylation
THCA = THC

THCA-A
C22H30O4

..

Supersaturated Sulfur Solutions

Temperature dependence of sulfur solubility in dimethyl sulfoxide and changes in concentration of supersaturated sulfur solutions at 25 °C

https://www.sciencedirect.com/science/article/abs/pii/S0167732220316949

Enhancement of transdermal permeation of cannabinoids and their pharmacodynamic evaluation in rats

https://pmc.ncbi.nlm.nih.gov/articles/PMC9812589/

..

Cannabinoids gel formulations were developed using FDA approved inactive ingredients: lactic acid (LA), polyethylene glycol-400 (PEG-400), N-methyl-2 pyrrolidone (NMP), dimethyl sulfoxide (DMSO).

Formulation containing lactic acid, NMP and DMSO showed significantly enhanced flux of cannabinoids as compared to formulation without LA, NMP and DMSO.

trying to matchup the chemistry close enough to make DMSO & Castor & combine the solubility, to match THC & Allicin attributes.

from what i understand THCA is water soluble, and requires Decarboxylation to become active oil soluble THC & CBD.

DMSO Sulfur reminds me of Pine Terpinene, regarding how volatile it is to heat, how its harvested via distillation, makes me think natrual Pine Terpinene is loaded with DMSO.

Decarboxylation means baking out a few extra molecules, making it dry.

letting Cannabis dry makes it active, but thats allowing the Nitrogen to evaporate, the Chlorophyll.

Polyphenol & Flavin are not exactly what they may appear, for example Polyphenol is the Color of the olant, from a Carbon configuration, meaning a spectrum of light, much like how DNA are points of light woven together.

C15 is a quarter part of C60, thats kind of my ultimate goal, to put everything, all the elements caramelized together, by sphere stacking into a C60.

..

Allicin/DMSO is for absorption, Chelation, Healing & Detox.

CBD/Castor is ?

Carbon Polyphenol, for binding Receptors & Microtubule, antiparasitic.

..

mix together in the best quality honey, vinegar, sea salts, & oil, and have to low temperature cook it down until carmalized.

that should balance the Ph & excess elements to a neutral Humic like compound, both a supplement & medicine.

the Carbon should be primed & charged with healing attributes.
..

Microtubules
Phosphorus Lipids
Sulfurtransferase
Naglu Gene
Heparan Sulfate
Sulfane Sulfur
Thiosulfate

N-acetyl-D-glucosamine
N-acetylglucosaminidase

https://en.m.wikipedia.org/wiki/NAGLU

N-acetylglucosaminidase, alpha is a protein that in humans is encoded by the NAGLU gene.

NAGLU gene encodes an enzyme that degrades heparan sulfate by hydrolysis of terminal N-acetyl-D-glucosamine residues (GlcNAc) in N-acetyl-alpha-D-glucosaminides.

N-acetyl-D-glucosamine
N-acetyl glucosamini dase

..

Dimethyl Sulfoxide (DMSO) as a Potential Source of Interference in Research Related to Sulfur Metabolism—A Preliminary Study

https://pmc.ncbi.nlm.nih.gov/articles/PMC11117631/

A unique phenolic extraction method from olive oil macerate of Hypericum perforatum using DMSO: Assessment of in vitro anticancer activity, LC-MS/MS profile, total phenolic content and antioxidant capacity

https://www.sciencedirect.com/science/article/pii/S0254629921000247

..

A spider’s feet hold a hairy, sticky secret

https://www.snexplores.org/article/spider-feet-hair-sticky-secret-dry-adhesion

Adhesion of Individual Attachment Setae of the Spider Cupiennius salei to Substrates With Different Roughness and Surface Energy

https://www.frontiersin.org/journals/mechanical-engineering/articles/10.3389/fmech.2021.702297/full

This knowledge can lead to new bioinspired materials with outstanding properties such as nanostructured reversible residue-free dry adhesives based on cellulose nanofibers, carbon nanotubes.

Vertically Aligned Carbon Nanotube Arrays

https://en.m.wikipedia.org/wiki/Vertically_aligned_carbon_nanotube_arrays

Van der Waals force

https://en.m.wikipedia.org/wiki/Van_der_Waals_force

Van der Waals forces include attraction and repulsions between atoms, molecules, as well as other intermolecular forces. They differ from covalent and ionic bonding in that they are caused by correlations in the fluctuating polarizations of nearby particles, a consequence of quantum dynamics.

Growth mechanism and kinetics of vertically aligned carbon nanotube arrays

https://onlinelibrary.wiley.com/doi/10.1002/eom2.12118

..

Palmitoylation
Palmitoleoylation
Pentadecanoic
Palmitic Acid
Pentadecylic Acid
Myelin Proteolipid Protein
Myristoylation
Prenylation
Farnesylation
DHHC
S-Acylation
Transsulfuration

https://en.m.wikipedia.org/wiki/Müller_glia

https://en.m.wikipedia.org/wiki/Radial_glial_cell

https://en.m.wikipedia.org/wiki/Carbonic_anhydrase

https://en.m.wikipedia.org/wiki/Fatty_acid_synthase

https://en.m.wikipedia.org/wiki/Fatty_acid_synthesis

https://en.m.wikipedia.org/wiki/Palmitic_acid

https://en.m.wikipedia.org/wiki/Palmitoylation

https://en.m.wikipedia.org/wiki/Myelin_proteolipid_protein

https://en.m.wikipedia.org/wiki/Prenylation

https://en.m.wikipedia.org/wiki/DHHC_domain

https://en.m.wikipedia.org/wiki/Myristoylation

..

Histone
Histidine
Histamine
Nitrogen
Imidazole
Heterocycle

Carbonic Anhydrase
Activators

Histamine, Metabolic Remodelling and Angiogenesis: A Systems Level Approach

https://pmc.ncbi.nlm.nih.gov/articles/PMC8000605/

Structure and mechanism of DHHC protein acyltransferases

https://pmc.ncbi.nlm.nih.gov/articles/PMC7483407/

Curation of the Mammalian Palmitoylome Indicates a Pivotal Role for Palmitoylation in Diseases and Disorders of the Nervous System and Cancers

https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1004405

The Palmitoylation State of PMP22 Modulates Epithelial Cell Morphology and Migration

https://journals.sagepub.com/doi/10.1042/AN20120045

Protein palmitoylation: Palmitoyltransferases and their specificity

https://pmc.ncbi.nlm.nih.gov/articles/PMC5478004/

Myelin proteolipid protein—the first 50 years

https://www.sciencedirect.com/science/article/abs/pii/S1357272501001364

Journey of cystatins from being mere thiol protease inhibitors to at heart of many pathological conditions

https://pmc.ncbi.nlm.nih.gov/articles/PMC7112400/

Optimizing human hepatocyte models for metabolic phenotype and function: effects of treatment with dimethyl sulfoxide (DMSO)

https://pmc.ncbi.nlm.nih.gov/articles/PMC5112488/

..

Cysteine
Histidine
Aspartate
Osmolyte

Palmitoylation is catalyzed by a family of enzymes that contain a DHHC (Asp-His-His-Cys) cysteine-rich domain which is directly involved in the palmitoyl transfer reaction.

Oxylipin

A decrease in oxylipin diols from linoleic acid, alpha-linolenic acid, and docosahexeanoic acid DHA, was observed 2h after injection with DMSO.

Improvement in neurodegenerative diseases and also cardiovascular diseases may be achieved by using inhibitors of an enzyme (soluble epoxide hydrolase) involved in formation of oxylipins. In Parkinson's disease, oxylipin profiles reflect the stage of the disease.

..

think i got a bead on whats going on.

DMSO does seem to help Palmitic & Oxylipin oils convert into Omega 3 Linolenic Acid, essentiality turning bad Myelin cholesterol onto good.

https://www.researchgate.net/publication/328101905_A_dose-dependent_effect_of_dimethyl_sulfoxide_on_lipid_content_cell_viability_and_oxidative_stress_in_3T3-L1_adipocytes

Central Carbon Metabolism in Candida albicans Biofilms Is Altered by Dimethyl Sulfoxide

https://pmc.ncbi.nlm.nih.gov/articles/PMC11121877/

The DMSO group exhibited enhanced levels of putrescine and glutathione and decreased levels of methionine and lysine.

Effect of DMSO on the Mechanical and Structural Properties of Model and Biological Membranes

https://www.sciencedirect.com/science/article/pii/S0006349520304823

DMSO molecule is amphiphilic

Role of sulfur amino acids in controlling nutrient metabolism and cell functions: implications for nutrition

https://www.cambridge.org/core/journals/british-journal-of-nutrition/article/role-of-sulfur-amino-acids-in-controlling-nutrient-metabolism-and-cell-functions-implications-for-nutrition/2749F7B38B1C8FAECC2C49D4D6561804

H2S-releasing nanoemulsions: a new formulation to inhibit tumor cells proliferation and improve tissue repair

https://pmc.ncbi.nlm.nih.gov/articles/PMC5356665/

https://substack.com/@amidwesterndoctor

https://www.midwesterndoctor.com/p/the-remarkable-history-and-safety

The Sulfur-Containing Amino Acids: An Overview

https://jn.nutrition.org/article/S0022-3166(22)08301-8/fulltext

Dimethylsulfoxide (DMSO) in Peripheral Nerve Regeneration

https://www.tandfonline.com/doi/10.1080/08941939.2019.1650314?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub 0pubmed

Vagus Nerve Stimulation as a Treatment Strategy for Gulf War Illness

https://apps.dtic.mil/sti/tr/pdf/AD1031305.pdf

..

https://en.m.wikipedia.org/wiki/Amphiphile

The hydrophilic group falls into one of the following categories.

Charged Groups

Anionic:

Examples, with the lipophilic part of the molecule represented by R, are:

carboxylates: RCO2−
sulfates: RSO4−
sulfonates: RSO3−
phosphates (charged functional group in phospholipids)

Cationic:

Examples:
ammoniums: RNH3+

Uncharged Groups (Polar)

Examples are alcohols with large R groups, such as diacyl glycerol (DAG), and oligo ethylene glycol with long alkyl chains.

..

Oil (Carbon)
Hydrogen + Carbon

Water (Oxygen)
Hydrogen + Oxygen

Lipid Peroxidation:
Piranha Solution
Thiobarbituric Acid

Peroxide Enzymes:
Superoxide Dismutase
Catalase
Glutathione Peroxidase

..

DMSO
Methionine
Methylthioninium
Methylene Blue

..

Blue Chloride

Quinine
Chloroquine
Methionine Blue
Methylthioninien Chloride

..

https://en.m.wikipedia.org/wiki/Methylene_(compound)

https://en.m.wikipedia.org/wiki/Carbene

https://en.m.wikipedia.org/wiki/Methionine

https://www.drbenlynch.com/methyl-group-methylation-methyl-trapping-what/

https://www.lifeextension.com/magazine/2007/7/cover_dmso

..

Natural Preservation of Human Brain, Warm Mineral Springs, Florida

https://www.cambridge.org/core/journals/american-antiquity/article/abs/natural-preservation-of-human-brain-warm-mineral-springs-florida/8899046368157E33A419FA9C104C4E63

..

Thioflavin
Amyloid (Stain-Dye)

Dimethyl
Amino
Phenyl
Chloride
Benzothiazol
Benzothiazolium
Benzothiazole
Fenbendazole

Oral dimethyl sulfoxide for systemic amyloid A amyloidosis complication in chronic inflammatory disease

https://pubmed.ncbi.nlm.nih.gov/16799886/

Eight weeks of DMSO administration improved the renal function and proteinuria in five out of ten renal amyloidosis patients, but had no effect on those patients with severe and/or advanced renal dysfunction.

No serious side effects were encountered with the DMSO treatment.

Conclusions:

Oral administration of DMSO is an effective treatment for amyloid A amyloidosis.

..

Cysteine
NAC
GlyNAC
Amino Acid
Left-Right Spin (D vs L)
Thiol
Sulfhydryl Group
Disulfide Bonds
Thiolate Anion
Methionine Sulfoxide
Sulfonium Ion
Metallothionein
Iron–Sulfur Protein
Sulfur-Carbon Relaxer
Heterocycle
Heteroatom
Polyphenol
Acid Dissociation Constant
Sugar/Acid/Base
Blood Meal Nitrogen
Diesel Exhaust Fluid
DEF Crystallization
Nitrogen-Sulfur Reaction

..

NAC
N-Acetyl Cysteine

GlyNAC
N-Acetyl Glucosamine

..

A Review on Medicinally Important Heterocyclic Compounds

https://openmedicinalchemistryjournal.com/VOLUME/16/ELOCATOR/e187410452202280/FULLTEXT/

Iron–Sulfur Protein

https://en.m.wikipedia.org/wiki/Iron–sulfur_protein

Metallothionein

https://en.m.wikipedia.org/wiki/Metallothionein

Superoxide dismutases: Dual roles in controlling ROS damage and regulating ROS signaling

https://pmc.ncbi.nlm.nih.gov/articles/PMC5987716/

Antioxidant action of deprotonated flavonoids: Thermodynamics of sequential proton-loss electron-transfer

https://www.sciencedirect.com/science/article/abs/pii/S0031942220311432

..

this last article mentions toxic Sulfur, but its only from a lack of Sulfur that it becomes toxic?

meaning when Sulfur becomes so low it is converted into the toxic compounds.

Sulfur Toxicity is a extreme lack of Sulfur, appears as Sulfur Sensitivity, but its actually a Herx reaction.

Black Powder
Nitrogen With Sulfur

Smokeless Powder
Nitrogen Without Sulfur

..

DFT/B3LYP study of the substituent effect on the reaction enthalpies of the individual steps of single electron transfer–proton transfer and sequential proton loss electron transfer mechanisms of chroman derivatives antioxidant action

https://www.sciencedirect.com/science/article/abs/pii/S2210271X11002532

Phenolic antioxidants (ArOH) inhibit oxidation by transferring their phenolic H atom to a chain-carrying peroxyl radical (ROO) at a rate much faster than that of chain propagation. This yields a nonradical product (ROOH) that cannot propagate the chain reaction.

Phenothiazine

https://en.m.wikipedia.org/wiki/Phenothiazine

..

A biochemical basis for induction of retina regeneration by antioxidants

https://pmc.ncbi.nlm.nih.gov/articles/PMC5753421/

Flavonoid nutraceuticals and ionotropic receptors for the inhibitory neurotransmitter GABA

https://www.sciencedirect.com/science/article/abs/pii/S0197018615300139

Turkey Tail
Lactobacillus
Astaxanthin

Russians were using them for regeneration & radiation protection.

the chemicals they produce are likely similar, to do with retinal.

Color Red & Retinal, to do with Vitamin A, which can be disrupted into Vitamin Toxicity, meaning a metabolic block that cascades everything else into a toxic collision, yet somehow a powerful medicine.

Quercetin is the Color Yellow, which goes with Green, is why grass stains on clothing is Yellow.

Blue is Chloride mixed with Sulfur in gas makes planetary bodies in space appear Blue.

to identify Amyloid requires dye colors Red, Blue or Green, from what i recall.

meaning it binds to it, therefore has the potential to neutralize the self assembling properties.

biological might as well be quantum physics how carbon folding makes different phenol colors, animal bodies & diamonds.

how a Hydrogen is a Proton made of 3 Subatomic Quarks in different positions, that 6 of them make a Carbon, with Electrons that dont even exist but as an electric bond potential, and isotopes are slight variations of the structure.

whats interesting is modern supliments of very specific Polyphenol colors are now just White powder, meaning Quercetin used to be Yellow capsules, somehow they have found a way to reduce them pure White.

refined Cannabis oil tincture is almost totally clear or just a bit Amber color, Fenbendazole is totally White with a slight radish taste.

but what Terpinene Phenolic acid if from is a very dark compound, coal, resin, tar, creosote.

recent test is a shot of DMSO in a full bottle of Olive Oil, and the very bottom of the bottle has a dark liquid, that i dont want to drink, whatever that part is, dont think i like it, the rest of the 90% top oil is more clear, and gives me a full body buzz, seems fine.

Melanin, Melatonin & Tryptophan all work together & how Serotonin is toxic.

The melanocyte photosensory system in the human skin

https://springerplus.springeropen.com/articles/10.1186/2193-1801-2-158

..

https://en.m.wikipedia.org/wiki/Astaxanthin

https://en.m.wikipedia.org/wiki/Polysaccharide-K

https://en.m.wikipedia.org/wiki/Bacteriocin

N-Acetylcysteine (NAC): Impacts on Human Health

https://pmc.ncbi.nlm.nih.gov/articles/PMC8234027/

..

B1
MSM
Quercetin

Benzimidazole and its derivatives as cancer therapeutics: The potential role from traditional to precision medicine

https://pubchem.ncbi.nlm.nih.gov/compound/fenbendazole

A round-up if the latest literature on fleas, ticks, and other parasites

https://www.veterinary-practice.com/article/a-round-up-if-the-latest-literature-on-fleas-ticks-and-other-parasites

https://en.m.wikipedia.org/wiki/Methoxy_group

Astaxanthin Bioactivity Is Determined by Stereoisomer Composition and Extraction Method

https://pmc.ncbi.nlm.nih.gov/articles/PMC9002770/

i do suspect the Sulfur is making Magnesium stay in the body bette for longerr, meaning possibly less Magnesium may be correct, while it is important for all kinds of things like Ph balance, bone regeneration & enzyme reactions, but the Sulfur might make it almost too strong reactions.

Thioflavin binds to Amyloid, but dosnt cure the problem, but is a clue as to what binds to it, and what is missing from the chemistry?

Congo Red & Methylene Blue also binds to it, so by matching them all together may give more clues.

Thioflavin reminds me of Thiamine, which is documented to bind with Amyloid.

Nitrogen & Sulfur seem to go hand in hand regarding binding in the same locations.

Thioflavin has 1 Sulfur, 2 Nitrogen, with Carbon structure identical to B1 Thiamine, with a Polyphenol-like Structure, and Betaine CH3 ends.

double Nitrogen to Sulfur. 2:1

so my two cents is im leaning that more Sulfur is better, the reason why is exactly why Thiamine B1 is used for Carbohydrate metabolism, like a zipper, it breaks things down better, Sulfur softens while Nitrogen makes things harder.

i like the results Fenbendazole has, but its a pharmaceutical chemical, and is slow by itself, same with Cannabis & Allicin.

so, im still not sure yet, exactly how & why.

Ivermectin might be fine, but its a much more complex compound, harder to understand whats happening.

Allicin is so damn close to DMSO, but the slightest difference can make a big difference.

what im leaning towards is DMSO/MSM & Quercetin.. and probably something else to help move things along quickly.

oil might be important for the reactions, Castor or something similar might be important, but still not sure, because Cannabis & Allicin is kind of an oil based thing.

Quercetin is just a generic Carbon Polyphenol, any others may be the same.

but the way it seems to work is by allowing Sulfur to spin freely, not exactly sure how.

NAC is just a combination of things, very similar to Citric or Vitamin C & a Glycine Amino Acid.

but it does something, maybe important.

its difficult to tell exactly tye raito, my only comparison is Epsom Salt is kind of 1:1 MSM/Sulfur & Magnesium.

but if you drink a shot of Epsom Salt you will have explosive diarrhea for a week.

but a shot of MSM is just a sour stomach.

"In neutral or only slightly acidic solutions, zinc displaces tin from its compounds, forming the metal."

all amyloid dye have a Sulfur.

Identification of Thioflavin T Binding Modes to DNA: A Structure-Specific Molecular Probe for Lasing Applications

https://pubs.acs.org/doi/10.1021/acs.jpclett.1c01254

Lugol
Iodine
Potassium
DMSO

Eicosanoid
Arachidonic Acid
Anandamide

Vasorelaxant
Cromakalim
Benzopyran
Pyran
Furan

Potassium
Orthosteric Agonist
Muscimol
GABA
Gaboxadol (THIP)
Isoguvacine
Progabide
Piperidine Sulfonic Acid

Level of Potassium Is Associated with Saturated Fatty Acids in Cell Membranes and Influences the Activation of the 9 and 13 HODE and 5 HETE Synthesis Pathways in PCOS

https://pmc.ncbi.nlm.nih.gov/articles/PMC9496543/

Saturated fatty acids lengthen to synthesize arachidonic acid. (Omega6)

the Na+/K+ pump is not able at some stage to compensate for the disturbances in the concentration of these electrolytes. Since modifying sodium, potassium, calcium, magnesium and trace element intake can affect arachidonic acid metabolism and eicosanoid production.

The synthesis of pro-inflammatory AA mediators that may be involved in improving the function of potassium channels. A group of organic compounds, including the benzopyran series, includes powerful vasorelaxant drugs, such as cromakalim, an example of a potassium channel opener used in the treatment of cardiovascular diseases.

The main component of cerebrosides, i.e., the cells responsible for the construction of the myelin sheath of nerve fibres. Therefore, if the level of K decreases, the synthesis pathway of this acid with pro-inflammatory properties increases, and, reaching the arachidonic acid, is desaturated into unsaturated derivatives. Epidemiological studies indicate the role of potassium in the clinical manifestations of cardiovascular disease, linking low serum potassium with a significantly higher risk of cardiovascular mortality.

..

Myelin
Ceramide
Sphingomyelin
Sphingomyelinase

Glucosylceramide is a major constituent of skin lipids, where it is essential for lamellar body formation in the stratum corneum and to maintain the water permeability barrier of the skin.

Monogalactosylceramide is the largest single component of the myelin sheath of nerves. Cerebroside synthesis can therefore give a measurement of myelin formation or remyelination. The sugar moiety is linked glycosidically to the C-1 hydroxyl group of ceramide, such as in lactosylceramide. Cerebrosides containing a sulfuric ester (sulfate) group, known as sulfatides, also occur in the myelin sheath of nerves.

Acid sphingomyelinase is one of the enzymes that make up the sphingomyelinase (SMase) family, responsible for catalyzing the breakdown of sphingomyelin to ceramide and phosphorylcholine.

..

https://blog.listentoyourgut.com/how-to-heal-internal-and-external-hemorrhoids/

..

https://en.m.wikipedia.org/wiki/Ceramide

https://en.m.wikipedia.org/wiki/Sphingomyelin

https://en.m.wikipedia.org/wiki/Acid_sphingomyelinase

https://en.m.wikipedia.org/wiki/Channelopathy

https://en.m.wikipedia.org/wiki/Methionine_sulfoxide

https://en.m.wikipedia.org/wiki/Eicosanoid

https://en.m.wikipedia.org/wiki/Eicosanoid_receptor

Potassium Channels
Potassium Efflux
Repolarization
Depolarization
Hyperpolarization

Depolarization Blocking Agents
Nicotinic Agonists
Nicotine
Suxamethonium
Decamethonium

Sodium and Magnesium are often antagonistic, as are Calcium and Potassium.

Potassium citrate also chelates metals that promote oxidation.

https://mineralbalancing.org/integrative-mineral-balancing-blog/calciummagnesium-ratio

https://www.sciencedirect.com/topics/agricultural-and-biological-sciences/potassium-citrate

Eicosanoid
Anandamide
Acylethanolamine
N-Arachidonoylethanolamine
(AEA)
Endocannabinoid

Orthosteric Agonist
Muscimol
GABA

Vasorelaxant
Cromakalim
Benzopyran
Cardiolipin

Myelin
Ceramide
Sphingomyelin
Sphingomyelinase

..

Potassium channels as molecular targets of endocannabinoids

https://pmc.ncbi.nlm.nih.gov/articles/PMC8293965/

Neuropharmacology of the Endocannabinoid Signaling System-Molecular Mechanisms, Biological Actions and Synaptic Plasticity

https://pmc.ncbi.nlm.nih.gov/articles/PMC2139910/

..

Myelin Sheath

https://www.simplypsychology.org/myelin-sheath.html

Combined malonic and methylmalonic aciduria

https://en.m.wikipedia.org/wiki/Combined_malonic_and_methylmalonic_aciduria

..

The Electrophysiology of Hypo- and Hyperkalemia

https://pmc.ncbi.nlm.nih.gov/articles/PMC5399982/

Novel insights into the modulation of the voltage-gated potassium channel KV1.3 activation gating by membrane ceramides

https://pmc.ncbi.nlm.nih.gov/articles/PMC4598779/

Oxidation leads to polar methionine sulfoxide (Met-O) which can be reversed by methionine sulfoxide reductases (MSRA).

Potassium Binding Adjacent to Cationic Transition-Metal Fragments: Unusual Heterobimetallic Adducts of a Calix[4]arene-Based Thione Ligand

https://pubs.acs.org/doi/10.1021/acs.inorgchem.7b02441

Differentiating Sulfur Compounds

Sulfa Drugs, Glucosamine Sulfate, Sulfur, and Sulfiting Agents

http://www.itmonline.org/arts/sulfa.htm

Potassium Metabolism

https://www.sciencedirect.com/topics/medicine-and-dentistry/potassium-metabolism

https://en.m.wikipedia.org/wiki/Pyruvate_dehydrogenase_complex

https://en.m.wikipedia.org/wiki/Pregnenolone_sulfate

https://en.m.wikipedia.org/wiki/Steroid_sulfate

..

Mapping Brain Metals to Evaluate Therapies for Neurodegenerative Disease

https://pmc.ncbi.nlm.nih.gov/articles/PMC3843008/

..

Pyruvate
Magnesium
Potassium
Calcium
Oxalate

https://healthrepository.org/can-low-potassium-cause-hair-loss/#Natural_Remedies_to_Grow_Hair

https://www.livestrong.com/article/510881-what-is-potassium-cocoate/

https://hormonesmatter.com/thiamine-deficiency-causes-intracellular-potassium-wasting/

https://drhuldaclark.org/fluke-disease/

..

Host-Parasite Interactions in Individuals with Type 1 and 2 Diabetes Result in Higher Frequency of Ascaris lumbricoides and Giardia lamblia in Type 2 Diabetic Individuals

https://pmc.ncbi.nlm.nih.gov/articles/PMC5818974/

https://en.m.wikipedia.org/wiki/N-Acylethanolamine

https://en.m.wikipedia.org/wiki/Cardiolipin

https://en.m.wikipedia.org/wiki/NLRP3

..

Potassium
NLRP3
Prion
Myelin

Activation of the NALP3 inflammasome is triggered by low intracellular potassium concentration. Cell Death

https://www.nature.com/articles/4402195

The potential convergence of NLRP3 inflammasome, potassium, and dopamine mechanisms in Parkinson’s disease

https://www.nature.com/articles/s41531-022-00293-z

Molecular dynamics and principal components of potassium binding with human telomeric intra-molecular G-quadruplex

https://pmc.ncbi.nlm.nih.gov/articles/PMC4444812/

Dimethyl sulfoxide (DMSO) is a stabilizing co-solvent for G-quadruplex DNA

https://www.sciencedirect.com/science/article/abs/pii/S0301462221002246

..

Bee venom contains at least 18 pharmacologically active components including various enzymes, peptides and amines. Sulfur is believed to be the main element in inducing the release of cortisol from the adrenal glands and in protecting the body from infections.

The bee product bee venom (BV, apitoxin) contains approximately eighteen active pharmaceutical ingredients (including enzymes, sulfur, peptides, and amines). Sulfur is believed to be the main chemical component of BV, promoting the release of cortisol, which acts as an anti-inflammatory and anti-arthritic substance.

The main amino acids in bee venom are cysteine and methionine, both of which contain sulphur. Sulphur is important in inducing cortisol release from the adrenal glands.

Mellitin is believed to be the main active agent.

Melittin is a small peptide with no disulfide bridge.

..

Potassium
Carbohydrate
Metabolism
Pyruvate Kinase

Potassium Channels, Glucose Metabolism and Glycosylation in Cancer Cells

https://pmc.ncbi.nlm.nih.gov/articles/PMC10178682/

..

Which electrolyte is responsible for carbohydrate metabolism?

Potassium is the electrolyte responsible for carbohydrate metabolism.

Explanation:

The electrolyte that is responsible for carbohydrate metabolism is potassium.

Carbohydrate metabolism refers to the overall process of breaking down carbohydrates into glucose, which is a crucial source of energy for cells. Potassium plays a vital role in this process by acting as a cofactor for enzymes involved in the breakdown of carbohydrates.

For example, potassium is necessary for the functioning of the enzyme pyruvate kinase, which is involved in the final step of glycolysis, the first stage of carbohydrate metabolism. Glycolysis converts glucose into pyruvate, and pyruvate kinase requires potassium to catalyze this reaction.

Pyruvate is converted into acetyl-coenzyme A, which is the main input for a series of reactions known as the Krebs cycle (also known as the citric acid cycle or tricarboxylic acid cycle).

Pyruvate is a key intersection in the network of metabolic pathways. Pyruvate can be converted into carbohydrates via gluconeogenesis, to fatty acids or energy through acetyl-CoA, to the amino acid alanine, and to ethanol. Therefore, it unites several key metabolic processes.

pyruvic acid may be prepared by heating a mixture of tartaric acid and potassium hydrogen sulfate, by the oxidation of propylene glycol by a strong oxidizer (e.g., potassium permanganate or bleach).

..

DMSO
NAC
Castor
Potassium
Magnesium
Iodine

there is a secret function regarding Sulfur reactions as the main component to the healing properties of both Bee Venom & Sunlight Vitamin D.

im trying to get this same effect by DMSO, NAC, Castor Oil, Potassium Iodide in sunlight to switch Hydrogen with a Sulfur.

what my test have uncovered..

Vitamin D, Melatonin, Bee Venom Therapy ect.. all of these are to trigger an outcome from very specific Sulfur reactions.

DMSO, Fatty Acid (Castor Oil), Potassium, Magnesium, (and maybe a pinch of Iodine)

may need to be put in the sun (sun-tea) to make the dimethyl bond from DMSO to the Hydrogen/Proton of the Oil, possibly the Potassium Oil Surfactant properties can help make this bond.

what it seems to do is begin a redox cascade breaking apart things like Oxalate & Histamine (toxic acids) via Pyruvate.

i have already taken a few swigs from this first test trial, and the redox & enzyme reactions are going strong many days afterwards.

not quite like a Herx reactions, more of a body & head buzz.

specifically my worn-out joints, back, hips, knees, they are extra sore & tender now, like something is going on with inflammation injuries.

the buzzing is identical to taking 6000 mg of Thiamine B1 megadose has same feeling & buzzing, but this new recipe is multiple times stronger effects.

dont exactly know what the Iodine is doing, but apparently has an affinity to Potassium for making Pyruvate & Carbon Carbohydrate Metabolism.

people are reporting DMSO & Potassium Iodine is curing chronic hemorrhoids & disolves giant hardened cysts.

..

Complex formation of potassium salt of highly fatty acid with hemagglutinin protein in influenza virus via exothermic interaction

https://pmc.ncbi.nlm.nih.gov/articles/PMC9240363/

Fatty acid potassium improves human dermal fibroblast viability and cytotoxicity, accelerating human epidermal keratinocyte wound healing in vitro and in human chronic wounds

https://pmc.ncbi.nlm.nih.gov/articles/PMC8273623/

Potassium channels as molecular targets of endocannabinoids

https://pmc.ncbi.nlm.nih.gov/articles/PMC8293965/

A high concentration of DMSO activates caspase-1 by increasing the cell membrane permeability of potassium

https://pmc.ncbi.nlm.nih.gov/articles/PMC5809660/

A study of electrolyte disturbances in patients with chronic stable asthma and with asthma attacks

https://www.sciencedirect.com/science/article/pii/S0422763814000727

The Role of Inflammasome Activation in Early HIV Infection

https://pmc.ncbi.nlm.nih.gov/articles/PMC8478595/

Sensing low intracellular potassium by NLRP3 results in a stable open structure that promotes inflammasome activation

https://www.science.org/doi/10.1126/sciadv.abf4468

Chronic kidney disease leads to microglial potassium efflux and inflammasome activation in the brain

https://www.kidney-international.org/article/S0085-2538(24)00535-0/fulltext

Malarial Hemozoin Activates the NLRP3 Inflammasome through Lyn and Syk Kinases

https://pmc.ncbi.nlm.nih.gov/articles/PMC2722371/

Molecule interacts with prion proteins to alter cell behaviour

https://www.ualberta.ca/en/medicine/news/2014/april/prion-proteins-potassium-channels.html

..

Replace/Correct the Magnesium Deficiency Before Potassium (Hypokalemia)!

https://eddyjoemd.com/hypokalemia-magnesium/

Magnesium Modulates ROMK Channel–Mediated Potassium Secretion

https://pmc.ncbi.nlm.nih.gov/articles/PMC3014024/

Polyphosphates induce amyloid fibril formation of α-synuclein in concentration-dependent distinct manners

https://pmc.ncbi.nlm.nih.gov/articles/PMC8059054/

Potassium, the hidden bone guardian

https://betterbones.com/bone-nutrition/potassium-benefits/

The significance of glucose, insulin and potassium for immunology and oncology: a new model of immunity

https://pmc.ncbi.nlm.nih.gov/articles/PMC1201164/

Potassium Intake, Bioavailability, Hypertension, and Glucose Control

https://pmc.ncbi.nlm.nih.gov/articles/PMC4963920/

Mineral requirements for mitochondrial function: A connection to redox balance and cellular differentiation

https://www.sciencedirect.com/science/article/pii/S0891584922000752

Sodium citrate or Potassium citrate in soap

https://classicbells.com/soap/citrate.asp

Dr. Jack Kruse

Sunlight has to sulfate cholesterol FIRST to get the Vitamin D train rolling in the skin. When it is sulfated it becomes water soluble in blood. When it isn't you upregulate LDL production. So taking D3 pills and living inside is raising your LDL.

Cholesterol and Vitamin D3 are nearly identical in chemical structure. Most people do not know this. Sunlight naturally sulfates these things (pic below). The only difference in both bio-molecules is a single double bond in the second ring of the cholesterol backbone. Remember light is BURIED at the electronic level in all things including cholesterol and Vitamin D. Your pills soaked in seed oil do not.

This gives Vitamin D3 one less hydrogen atom than the closed ring of cholesterol.

One hydrogen is the only difference at the atomic scale between them but there is a shit ton of energy buried in the bond biochemists do not see so they ignore it at your peril. Here you will see the wisdom of Tensegrity 6 play its role. Look it all the charge density sunlight adds to the system that a pill cannot.

Hydrogen is the ultimate chameleon for the sulfation and differentiation of cholesterol and Vitamin D3. What does it do? Vitamin D3 is synthesized from cholesterol esters in the skin upon exposure to specific frequencies of sunlight. When this happens and calcium becomes normal in the blood serum, both molecules remain sulfated by melatonin. This implies sunlight is a calcium channel blocker.

Melanin holds charge so it is also a calcium channel blocker. ACTH made from the POMC gene causes calcium to flow. It does the exact opposite of what other cleavage products of POMC do.

THIS HYDROGEN INTERACTION WITH and WITHIN THE SUN IS HUGE to maintain the sulfation of lipids and proteins. This is the basis of how a quantum dot battery is built in animals to create light from the metabolism that controls biochemicals in us.

It turns out how hydrogen acts chemically, depends wholly on the environment it is within. Does this means hydrogen can take different forms in our body if the environment of that region is controlled by information in some way? Is it a donor or a collector of electrons? Is it a metal or a gas? Science depends on compelling narratives, and few people seem to know the real story behind hydrogen. In fact, Nature has shown us how hydrogen can act as a metal or non-metal. Hydrogen makes life a cooperative quantum dance and it can make other elements do things they normally would not do.

..

https://en.m.wikipedia.org/wiki/Lipofuscin

Lipofuscin appears to be the product of the oxidation of unsaturated fatty acids and may be symptomatic of membrane damage, or damage to mitochondria and lysosomes. Aside from a large lipid content, lipofuscin is known to contain sugars and metals, including mercury, aluminium, iron, copper and zinc.

..

https://pulse-academy.com/2022/02/10/macular-degeneration-in-the-light-of-the-pulse-spectral-analysis-part-3/

The composition of lipofuscin includes fats (20-50%), proteins (30-60%), a significant amount of carbon, nitrogen, phosphorus, sulfur, magnesium and aluminum. Fats are mostly represented by phospholipids (cephalin, lecithin, sphingomyelin), as well as cholesterol, triglycerides and products of peroxidation and polymerization of fatty acids. The most abundant amino acids in lipofuscin granules are glycine, valine, alanine, and proline.

..

Lipofuscin Hypothesis of Alzheimer's Disease

https://pmc.ncbi.nlm.nih.gov/articles/PMC3235942/

Key Words: Aβ protein, Alzheimer's disease, Amyloid, Lipofuscin, Macular degeneration, Neurofibrillary tangles

..

its amazing blue light makes Amyloid almost exactly like Prion does.

im just going to expect Dr Jack Kruse is right about most everything at this point.

Blue light spectrum

Biological effects of high-energy visible light

Lipofuscin

Dioxin
Fuscin
Furan
Heparan
Insulin
Plaque
Amyloid

Digoxin Toxicity
Cardiac Glycoside

all of the compound are CHONS, very specifically without Potassium.

Dioxin was the biggest clue, fire smoke (Dioxin) separated from the ashes (Lye Potash Potassium).

Functional Amyloid and Other Protein Fibers in the Biofilm Matrix

https://pmc.ncbi.nlm.nih.gov/articles/PMC6173796/

..

Tubulin
Microtubule
Acetylation
Amyloid

Of microtubules and memory: implications for microtubule dynamics in dendrites and spines

https://pmc.ncbi.nlm.nih.gov/articles/PMC5221613/

Microtubule damage shapes the acetylation gradient

https://www.nature.com/articles/s41467-024-46379-5

Tubulin acetylation: responsible enzymes, biological functions and human diseases

https://pmc.ncbi.nlm.nih.gov/articles/PMC11113413/

..

Cytoskeletal Drugs
Nocodazole

https://en.m.wikipedia.org/wiki/Cytoskeletal_drugs

https://en.m.wikipedia.org/wiki/Nocodazole

Cytoskeletal drugs are small molecules that interact with actin or tubulin.

..

ATPase
Helicase
Tubulin
Microtubule
KATP
Potassium
SV40 T-antigen

Tubulin pools in human erythrocytes: altered distribution in hypertensive patients affects Na+, K+-ATPase activity

https://pmc.ncbi.nlm.nih.gov/articles/PMC11114553/

Potassium Channels
Potassium Efflux
Repolarization
Depolarization
Hyperpolarization

Depolarization Blocking Agents
Nicotinic Agonists
Nicotine
Suxamethonium
Decamethonium

AHA
Alpha Hydroxy Acid
Carboxylic Acid
Citric Acid

..

finding all disease have a direct connection to Potassium inside of the cell vs outside the cell, HIV, Malaria ect..

to get Potassium back inside the cell is a bit tricky, and does appear to trigger a Herx, my body is pretending to have a cold.

Potassium Channels have a direct link to Endocannabinoid system, ATP, Antioxidant reactions with ROS & Radicals, Sulfide Bonds, Cytokines, Immune Response, Ph Homeostasis.

just about everything to do with health vs disease.

im not going to recommend this until i have more time testing, but its basically this.

Castor 90%
DMSO 5%
Potassium Citrate 5%

NAC may not be as important because i think the Citrate is doing what it needs, may also be good with a little Magnesium.

so its not a crazy formula, but it seems to be making Potassium active for cells.

Potassium Citrate is for kidney stones, breaks up toxic acid buildup crystallization plaque, but by itself flushes right out, this other way makes it keep working for days.

i think they are over complaining whats going on, because all the different diseases seem to do exactly the same thing, make toxic acids to kick out all the cellular potassium, the force the cell to manufacture toxic DNA that make plaque forming peptides.

Nicotine helps hold the Polarity of Potassium to stay in the cell, thats all it was really doing?

parasitic microbes emter cell, produce toxic acids, binding & knock-out Potassium via Depolarization, that cascades into Magnesium, Zinc depletion.

people with neurological diseases always seem to have the same odd patterns, Potassium Deposits, Zinc deficiency & smoking cigarettes seems to help them think.

more Zink & Cigarettes aint the core of the problem & taking a bunch of Potassium wont necessary get back into the cell.

Potassium is a Chelate to heavy metals, Sulfur is a Chelate to Potassium, ect.. and the only way in is Oil Solubility of Hydrogen-Proton Pump.

all the years testing different things, always was afraid to mess with both Potassium & Sulfur DMSO, for whatever reasons.

thinking back to Electrolyte Imbalances, they always seems to imply it takes months to fix an unbalance.

likely be because the FDA capped Potassium supliments to 99 ml, also without the other 3 parts it dosnt really get back into the cells.

dont think it really takes much Potassium anyway, im not using very much, it just keeps going, flipping enzymes or something.

also think Potassium in the Cell is what holds the other essential micronutrient minerals locked in position, like Copper, Iron, Molybdenum Selenium ect..

while Magnesium is of critical importance, Potassium is very close to the master mineral.

and Sodium & Calcium can be the master minerals outside of the cells.

but im trying to understand intercellular, because when it is operating correctly, without disease, then the extracellular appears to operate correctly, as if inside the cell is the command center for health & strong DNA.

bet 5 bucks.. Cannabis Oil helps put Potassium back in cells, found a paper said similar pathways.

Epsom Salt is Magnesium & MSM (DMSO-2).

so by adding Potassium Citrate with Epsom Salt is basically the ingredients, foot soak, just remember this stuf is Antihistamine, and its very powerful.

what was most fascinating is all disease begans with Potassium being knocked out ofnthe cell, then follows things like Iron & Magnesium.

and why Nicotine & Nicotinic acid (Nician) seem to help, what its actually doing is keeping the Potassium in the cell.

so i was initially going about it backwards, or a secondary step by using Niacin, just to keep Potassium in the cell, so now im going more direct by just putting it back in.

Niacin is just to hot & irritating, probably makes more histamine then is worth the trouble.

what is strange is DMSO & Potassium causes similar yet stronger reactions as Thiamine, to the point that my body thinks its got a stuffy cold, but i dont.

i know Niacin protects intellectual Potassium, but B1 seems to effect it as well, in some way.

so its basically just this im testing.

Potassium Citrate
Magnesium Sulfate

one is used for breaking up kidney stones, the other a laxative for colon exams.

non-toxic, doctors use both compounds for other random things.

but what i think is going on is all 4 elements together are the perfect combination to break up biofilms & toxic acids.

the ingredients are literally dirt cheap & once combined, it takes so little yo make the reactions start & it just keeps on going, meaning might only need to take a topical application once a week.

meaning when the Potassium, Magnesium, Sulfate & Citrate are mixed together, it locks an electric enzyme unzipper or wheel, and it just keeps unzipping toxic acids over & over again.

my problem fighting mycoplasma with antibiotics, alkaloids, or whatever, is that half the mycoplasma colony is dormant sleeping in bone marrow, mitochondria, blood cells & biofilm.

so most of the medications are causing a cytokine storm & making extra histamine to deal with.

i suspect its doing what Niacin & Thiamine are supposed to do, same general outcome, but less excess Nitrogen to deal with.

comparing the two papers data points, one thing stood out.

attempt to fix mitochondria tubulin & homeostasis, how Sulfate & Iron work together.

something about Tubulin & Microtubule degeneration & Amyloidosis.

a chain reaction that appears to begin with Potassium disruption, then a cascading collapse, specifically regarding Sulfate-Iron bond, then Iron & Potassium deposits eventually wrecking havoc.

..

Potassium
Deuterium

..

hair follicle
potassium ion channels
antihypertensive agents
minoxidil sulfate

..

trying to find a link to ..

Mycoplasma Fermentans (Incognitus), SV40, Hela Immortal Cell, Dormancy, Bone Cancer, and the evolutionary link between Malaria (Plastid) vs Bacteria (Plasmid).

Circular DNA, Mitochondrial DNA, Circular Bacterial Chromosome, Quorum Sensing, Biological Mimicking & Dormancy.

Synthetic Blood & Cybernetics, Smart Dust

..

Alterations in intracellular potassium concentration by HIV-1 and SIV Nef

https://pmc.ncbi.nlm.nih.gov/articles/PMC2396157/

Role of Potassium in Human Immunodeficiency Virus Production and Cytopathic Effects

https://www.sciencedirect.com/science/article/pii/S0042682298992510

G protein-coupled and ATP-sensitive inwardly rectifying potassium ion channels are essential for HIV entry

https://pmc.ncbi.nlm.nih.gov/articles/PMC6411958/

i dont like the conclusions of the direction the papers are going, by blaming Intracellular Potassium as the cause of infection & replication, and looking for more effective Potassium Pump Inhibitors, just seems ignorant, or at least misleading from the toxic acids (fermentation) disrupting the homeostasis to begin with.

i guarantee, whatever a viris is alive or not, its making acids & disrupting Potassium Homeostasis, knocking it out of the cell.

..

Photo-Switchable Sulfonylureas Binding to ATP-Sensitive Potassium Channel Reveal the Mechanism of Light-Controlled Insulin Release

https://pmc.ncbi.nlm.nih.gov/articles/PMC8667036/

Beyond Homeostasis: Potassium and Pathogenesis during Bacterial Infections

https://pmc.ncbi.nlm.nih.gov/articles/PMC8486168/

..

my take on this last article is the pathogens dont want the Potassium, but the ATP around the potassium.

KATP Channel
ATP-Sensitive Potassium Channel
Heparin
Heparan Sulfates
Sulfonylurea Receptor (SUR)
Adenosine Triphosphate (ATP)
Intercellular
Mitochondria

Sulfonylurea Receptor (SUR) proteins are subunits of the Inward-Rectifier Potassium Ion Channels

A channel that is "inwardly-rectifying" is one that passes current (positive charge) more easily in the inward direction (into the cell) than in the outward direction (out of the cell).

..

Potassium and Sodium Channels and the Warburg Effect: Biophysical Regulation of Cancer Metabolism

https://pmc.ncbi.nlm.nih.gov/articles/PMC8370285/

Analysis of the Biogenesis of Heparan Sulfate Acetyl-CoA:α-Glucosaminide N-Acetyltransferase Provides Insights into the Mechanism Underlying Its Complete Deficiency in Mucopolysaccharidosis IIIC*

https://pmc.ncbi.nlm.nih.gov/articles/PMC2951197/

..

i think the pathogens follow the uptake of Potassium to get the ATP, ferment toxic acids & push all the Potassium out, make insulin resistant plaque.

Heparan & Phosphorus have a direct link to Amyloid Plaque formation.

thats a cellular Sulfur & ATP, and all having to do with Potassium.

..

Insecticidal Soap

Insecticidal soap's active ingredient is most often a potassium salt of fatty acids.

Insecticidal soap should be based on long-chain fatty acids (10–18 carbon atoms) because shorter-chain fatty acids tend to be damaging for the plant (phytotoxicity). Short (8-carbon) fatty-acid chains occur for example in coconut oil and soaps.

'Green Soap' is a potassium/coconut oil soap [that] has also been shown to be effective, as an unlabeled insecticide.

https://blogs.k-state.edu/kansasbugs/2020/06/12/fundamentals-of-using-soaps-as-insecticides/

seems strange the only soap effective enough to be both safest & most effective is Potassium & Fatty Acid.

makes me think about mycoplasma, as a White Fly.

its not the amount of Potassium, seems to require Magnesium, Sulfate & Citrate, to make it activated.

K+ Potassium
Mg++ Magnesium
S Sulfate
O Oxygen
X Carbon
H Hydrogen (Fatty Acid, Oil)

Citric Acid seems to light up the reactions, everything ultimately appears to depend upon Potassium, as the master mineral.

Potassium Intake, Bioavailability, Hypertension, and Glucose Control

https://pmc.ncbi.nlm.nih.gov/articles/PMC4963920/

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Centrosome
Centromere
Nucleosome

Structure of centromere chromatin: from nucleosome to chromosomal architecture

https://pmc.ncbi.nlm.nih.gov/articles/PMC5509776/

https://en.m.wikipedia.org/wiki/Centrosome

https://en.m.wikipedia.org/wiki/Centromere

https://en.m.wikipedia.org/wiki/Nucleosome

There are five families of histones, which are designated H1/H5 (linker histones), H2, H3, and H4 (core histones). The nucleosome core is formed of two H2A-H2B dimers and a H3-H4 tetramer. The tight wrapping of DNA around histones, is to a large degree, a result of electrostatic attraction between the positively charged histones and negatively charged phosphate backbone of DNA.

Centrosomes are composed of two centrioles arranged at right angles to each other, and surrounded by a dense, highly structured mass of protein termed the pericentriolar material (PCM). The PCM contains proteins responsible for microtubule nucleation and anchoring — including γ-tubulin, pericentrin and ninein.

..

DNA
Phosphorothioate
Phosphodiester
Thioaptamer

Development of Phosphorothioate DNA and DNA Thioaptamers

https://pmc.ncbi.nlm.nih.gov/articles/PMC5618299/

Biological coordination chemistry of magnesium, sodium, and potassium ions. Protein and nucleotide binding sites

https://www.sciencedirect.com/science/article/abs/pii/0010854594800685

Citrate-Ascorbate Synthesis

Ascorbate (C6H8O6)
Citrate (C6H8O7)

Ascorbate
Ascorbic Acid

Dihydroxyethyl
Dihydroxyfuran

Furan
Lactone
Ketogluconic Acid
Enediol
Carbonyl

Ascorbic acid is a furan-based lactone of 2-ketogluconic acid. It contains an adjacent enediol adjacent to the carbonyl.

Ascorbate Peroxidase
Ascorbate Ferrireductase
Ascorbate Dioxygenase
Ascorbate Oxidase
Glutathione-Ascorbate Cycle

Transmembrane

..

https://en.m.wikipedia.org/wiki/Chemistry_of_ascorbic_acid

https://en.m.wikipedia.org/wiki/Mineral_ascorbates

https://en.m.wikipedia.org/wiki/Ascorbate_peroxidase

https://en.m.wikipedia.org/wiki/Ascorbate_ferrireductase_(transmembrane)

https://en.m.wikipedia.org/wiki/Ascorbate_2,3-dioxygenase

https://en.m.wikipedia.org/wiki/L-ascorbate_oxidase

https://en.m.wikipedia.org/wiki/Glutathione-ascorbate_cycle

..

Potassium Citrate
Magnesium Sulfate

Recent Updates on Anti-Inflammatory and Antimicrobial Effects of Furan Natural Derivatives

https://pmc.ncbi.nlm.nih.gov/articles/PMC7443407/

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Vagus Nerve
DMSO

Collagen
Elastin
Proteoglycans
Glucosamine
Chondroitin

https://www.americancancercenternigeria.com/shop/item.aspx?itemid=2

The vagus nerve and the inflammatory reflex—linking immunity and metabolism

https://pmc.ncbi.nlm.nih.gov/articles/PMC4082307/

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Calcium (Ca2+)
Hypercalcemia
Intracellular
Signaling Molecules
Calcification
Mitochondria
Cellular Senescence

Regulation and role of calcium in cellular senescence

https://www.sciencedirect.com/science/article/abs/pii/S0143416023000131

Mitochondrial Dysfunction: Cause or Consequence of Vascular Calcification

https://pmc.ncbi.nlm.nih.gov/articles/PMC8010668/

Microglial Potassium Channels: From Homeostasis to Neurodegeneration

https://pmc.ncbi.nlm.nih.gov/articles/PMC8698630/

Neuroinflammation: The Devil is in the Details

https://pmc.ncbi.nlm.nih.gov/articles/PMC5025335/

..

Lipedema
Edema
Glycogen
Phosphocreatine
Bioenergetic Systems

https://www.lipedema.org/research-grants/

https://morethanfat.com/lipedema-and-nutrition/lipedema-nutrition-and-common-supplements

Renal Dysfunction in Cirrhosis: Diagnosis, Treatment, and Prevention

https://pmc.ncbi.nlm.nih.gov/articles/PMC1480573/

..

Cold Shock Proteins
Y-Box Binding Protein
YB-1
DNA Binding Protein B
DbpB
M4 ipRGCs
Potassium
DMSO
Methylene Blue
Blue Light
Optogenetics
Melanopsin
Leptin
Cytokine
Endocrine System
Vagus Nerve

Cold shock proteins: from cellular mechanisms to pathophysiology and disease

https://biosignaling.biomedcentral.com/articles/10.1186/s12964-018-0274-6

..

Potassium
Hyperpolarization
GABA-B Receptor
G Protein
Guanine Nucleotide
Binding Protein
Coupled Receptor
GTPase
Intracellular

Potassium channel-based optogenetic silencing

https://pmc.ncbi.nlm.nih.gov/articles/PMC6218482/

Optogenetics. Engineering of a light-gated potassium channel

blue-light-induced K(+) channel 1 (BLINK1) engineered by fusing the plant LOV2-Jα photosensory module to the small viral K(+) channel Kcv. BLINK1 exhibits biophysical features of Kcv, including K(+) selectivity and high single-channel conductance but reversibly photoactivates in blue light. Opening of BLINK1 channels hyperpolarizes the cell to the K(+) equilibrium potential.

https://en.m.wikipedia.org/wiki/Hyperpolarization_(biology)

https://en.m.wikipedia.org/wiki/GABAB_receptor

https://en.m.wikipedia.org/wiki/G_protein-coupled_receptor

..

Mitochondrial osmoregulation in evolution, cation transport and metabolism

https://www.sciencedirect.com/science/article/pii/S0005272821000013

As organisms evolved to have less sodium cations abundant cytosols and replace Na+ with K+ and over time with other osmolytic solutes, mitochondria were forced to keep pace in eukaryotes. Thus, mitochondria became more dependent on potassium cations as the major osmolyte.

The nitrogen–potassium intersection: membranes, metabolism, and mechanism

https://onlinelibrary.wiley.com/doi/10.1111/pce.12671

Nitrogen is an essential constituent of a vast array of metabolites and structural compounds, including proteins, nucleic acids, chlorophyll, co-enzymes, phytohormones and secondary metabolites, while the main functions of K+ are as a major osmolyte and source of positive charge for electrical homeostasis and enzyme activation.

..

WHAT ARE THE CONCENTRATIONS OF DIFFERENT IONS IN CELLS?

https://book.bionumbers.org/what-are-the-concentrations-of-different-ions-in-cells/

..

Toxic
DNA Adduction
Mallard Reaction
Thiamine
Nucleotide
Asparagine
Acrylamide
Glycidamide
Oxiranecarboxamide
Amyloid
Synuclein
Lipofuscin

Heparan Sulfate
Glucosaminide
Glycosaminoglycan

Glycidamide inhibits the sodium/potassium ATPase protein present in the plasma membrane of nerve cells. Intracellular sodium increases and intracellular potassium decreases due to this inhibition. This causes depolarization of the nerve membrane. The depolarization triggers a reverse sodium/calcium exchange, which will cause calcium-mediated axon degeneration.

..

N-acetylcysteine for chronic kidney disease: a systematic review and meta-analysis

https://pmc.ncbi.nlm.nih.gov/articles/PMC8129408/

The role of leptin in selected skin diseases

https://pmc.ncbi.nlm.nih.gov/articles/PMC7532589/

Molecule interacts with prion proteins to alter cell behaviour

https://www.ualberta.ca/en/medicine/news/2014/april/prion-proteins-potassium-channels.html

Lipofuscin-bound iron is a major intracellular source of oxidants: Role in senescent cells

https://www.sciencedirect.com/science/article/abs/pii/S0891584910000638

..

Intracellular
Extracellular

Lipofuscin
Glycidamide

vs

Amyloidosis
Prion

Role of Intracellular Amyloid β as Pathway Modulator, Biomarker, and Therapy Target

https://pmc.ncbi.nlm.nih.gov/articles/PMC9103247/

Research in recent decades focused on the pathological role of extracellular amyloid β aggregation, widely neglecting the potential meaning of very early generation of amyloid β inside the cell.

A central hallmark of the disease is the presence of amyloidogenic plaques, formed by deposition, accumulation, and aggregation of the amyloid β peptide (Aβ) in the brain. The second well-described pathophysiological characteristic are neurofibrillary tangles, which result from hyperphosphorylation of the microtubule-associated Tau protein, consequently leading to cytoskeletal changes in neurons.

Potassium
N-Acetyl Cysteinate

Potassium Efflux
Neuroinflammation

Elevated BK channel currents, lead to increased potassium efflux and decreased intracellular potassium levels.

High extracellular K+ and reduced intracellular ATP, or increased AMP levels could trigger the activation of NLRP1 during hypoxia or after stroke.

changes in intracellular K+ concentrations after ischaemia trigger NLRP3 activation. Bacterial toxins can also cause K+ efflux, leading to the activation of the NLRP3 inflammasome.

Low intracellular K(+) is also a requirement for NALP1 inflammasome activation by lethal toxin of Bacillus anthracis.

NLRP1 in neuroinflammation and pyroptotic cell death.

Elevated NLRP1 inflammasome levels may be induced by potassium (K+) efflux, which is causative of the generation or spread of seizure activity in ... stimulate or stably overexpress NLRP1 in brain.

N-acetylcysteine attenuates the decline in muscle Na+, K+-pump activity and delays fatigue during prolonged exercise in humans.

..

The effect of N-acetylcysteine (NAC) on human cognition

https://www.sciencedirect.com/science/article/abs/pii/S0149763416303980?via%3Dihub

https://eurekamag.com/research/009/830/009830281.php

Mitochondria as a target for neuroprotection: role of methylene blue and photobiomodulation

https://pmc.ncbi.nlm.nih.gov/articles/PMC7262767/

ATP depletion has been shown to induce a cascade of adverse cellular events, including failure of membrane ion pumps, cellular potassium efflux, sodium influx, and membrane depolarization.

..
Hydroxyapatite
Calcium Phosphate
Potassium Nitrate
Arginine Calcium

https://www.todaysrdh.com/the-effectiveness-of-toothpastes-in-blocking-dentin-tubule-permeability/

..

Methylene Blue
Fenbendazole

Potassium Efflux
Osmolyte
Neuroinflammation

..

all this time testing specifically on B Vitamins, Magnesium ect.. all of it depends upon Potassium to function.

appears everything depends upon Potassium to anchor down the intracellular & mitochondria homeostasis.

Potassium is the master mineral, in my opinion.

the really toxic stuff from cigarettes & French Fries, the most carcinogenic chemical found in food, it directly connected to Potassium disruption.

years of testing supliments & herbs, nothing was so definitive as Potassium, it appears all other vitamins are useless if Potassium is not inside the cell.

and it absolutely does create Herx like reactions.

Potassium in cell makes ATP, outside the cell makes cellular calcification, bad fat, bad cholesterol, and processed sugars bind to DNA, causing all kinds of trouble.

i did "kind of" megadose the Potassium, because of the other ingredient used to make it absorb more effectively.

so it wasnt exactly too much Potassium, just made it stick in & absorb more effectively.

Potassium Citrate, Olive Oil, DMSO.. and a little extra Citric Acid.

i drank it, approximately a shot glass over the night, twice in two weeks, on the weekend.

the conclusion is that was intense, i should have learned from the first test to be more careful.

no gut pain or intestinal problems so much, just a very powerful Herx situation.

it makes you feel stoned, like a pot hangover, because Cannabinoids works with Potassium Channels.

got a few days of headache, disorientation, sleepy, head ringing, sinuses.

my suspension is the spot with the most pain or trouble, hit that spot first, typically.

i used a Magnesium & Oil Cream, added Potassium Citrate & MSM/DMSO.

just makes you feel like a hangover for a few days.

just seems like all the chaos with medical problems is a direct result of a lack of Intracellular Potassium.

is why Cannabinoids work the way they do.

Potassium is limited to 99mg by FDA, and we need 5000mg, most of it is excreted in urine.

so topical seems better anyway, Kidney Stones to Gout.

the idea im getting at is the similarities between just normal toxic food chemical soot & prion amyloidosis, specifically regarding whats its doing to Intracellular Potassium, that then makes chain links in the DNA for linking sugars, ultimately misfolding & plaque.

rapid old age via endosymbiont, the only thing that seems to really dislike is Potassium hot-rodded with something like NAC.

NAC has Nitrogen, Sulfur, Carbon, Sugar, Amino & Citrate.

its got everything to bind with the Potassium for a lethal injection for mitochondrial parasites.

Fenbendazole is so similar to Methylene Blue, Nitrogen Sulfur & Polyphenol Carbon structure.

and so.. is NAC

so is .. MSM, B3 with VitaminC or Citrate.

all protecting Potassium acting as Osmolyte, to stay in the cell.

from what i can tell, literally all disease states is doing this.. HIV, Schizophrenia, Cancer, Snake Bite, Anthrax, Amyloidosis, Osteoporosis, Diabetes ect..

just taking Potassium supliments is not the antidote, needs to work with something else, testing different combinations of things, at the moment Potassium Citrate, Magnesium Chloride, NAC, MSM, B3 Quercetin..

not not the quantity of Potassium but the ability to get it into the cells quickly & effectively.

Cannabinoids operate by modulating Potassium Channels, is why CBD helps Parkinson’s.

the trick is only using grandma's ole timey chemicals.

Potassium Citrate (Citrus) is used by doctors to break up kidney stones (Calcium Oxalate).

Magnesium Chloride is used to make skin cream for ladies.

Magnesium Sulfate (MSM) is Epsom Salt to soak feet in.

MSM is from rain & mineral spring water, DMSO harvested from trees.

its very likely it going to require a little Iodine to make this cell transfer happen, thats from seaweed.

DMSO is originally evaporated from the ocean, into cloud rain, collecting in deep tree roots.

notice all the ingredients are from the ocean.

Potassium ion efflux induces exaggerated mitochondrial damage and non-pyroptotic necrosis when energy metabolism is blocked

https://www.sciencedirect.com/science/article/abs/pii/S0891584923011863

The Role of Intracellular Potassium in Cell Quiescence, Proliferation, and Death

https://pmc.ncbi.nlm.nih.gov/articles/PMC10815214/

Distinct Molecular Mechanisms Underlying Potassium Efflux for NLRP3 Inflammasome Activation

https://pmc.ncbi.nlm.nih.gov/articles/PMC7793832/

Potassium Homeostasis, Oxidative Stress, and Human Disease

https://pmc.ncbi.nlm.nih.gov/articles/PMC5716641/

..

as Potassium is normally pushed out of the cell, it get bound by extracellular ATP & Nigericin.

Nigerian is a bacteria compound, and why is ATP outside of the cell anyways?

and why does ATP look like a Prion, is the bacteria mimicking ATP as Prion-like compound, that binds Potassium outside the cell?

ATP
Adenosine Triphosphate

Prion
Inositol Polyphosphate

sure ive seen a paper explaining similarities between Biofilms & Amyloidosis.

all i need to know is there is absolutely a connection to Potassium outside of the cell, then find out why.

what ive noticed taking Potassium Citrate, NAC & MSM.. is now B Vitamins complex actually do something noticeable.

and got a bottle of high quality Potassium Iodide, couple drops in water is a noticeable effect.

also taking Potassium too quickly doss seem to make blood amount high, and it may not take as much when its changed up with the other things, specifically to get back in the cell & break up Calcification.

using topical Potassium does appear to dry skin.

for some reason Potassium seems to be connected not only Kidney Stones, but Gallstones, Retinol or Retinol repairing, but dosnt have any documentation, just seems to fix things like Bile Duct issues.

strangest thing is that Thiamine would always give me a very slight ringing in my head, like maybe it doing something good in there not sure, ive got lots of history with brain issues, and havent taken it in a few months, just letting that test rest for awhile.

it interesting this is Potassium does the exact same thing, so that the reasin for suspecting a B-Vitamin role in Potassium.

Magnesium never did this, so its definitely neurological effect, but still not exactly sure whats going on.

but at first Potassium does Herx the system, but once thats over with, a sense of calm comes about.

..

Potassium Citrate
Kidney Stones

Magnesium Sulfate
Antihistamine

NAC (N-Acetyl Cysteine)
Gallstones

NAC & Quercetin:
Fenbendazole

Add Chloride:
Methylene Blue

NAC Synthesis:
Sugar (Carbon)
Citrus (Acid)
MSM (Sulfur)
B3 Niacin (Nitrogen)

Carmalized:
Quercetin (Polyphenol)

Intercellular Ions:
Potassium
Magnesium
Chloride

..

Hexokinase dissociation from mitochondria promotes oligomerization of VDAC that facilitates NLRP3 inflammasome assembly and activation

Keep up the good work. 👏🎵

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